Ocular Manifestations of Scleroderma

Tailor, Rajen; Gupta, Ajay; Herrick, Ariane L.; Kwartz, J

doi:10.1016/j.survophthal.2008.12.007

Cited by 76 publications

(75 citation statements)

References 73 publications

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“…Keratoconjunctivitis sicca (KCS) was present in 34 68%) patients which is within the range of previous study that showeda prevalence ranging from 37-79% of patients [5].The current study reported that eyelid skin changes were seen in 56 % of the patients. The fibrotic changes seen in the eyelids may be explained by excessive deposition and accumulation of extracellular matrix, mainly type I collagen, in the dermis [23].…”

Section: Discussionsupporting

confidence: 85%

“…The fibrotic changes seen in the eyelids may be explained by excessive deposition and accumulation of extracellular matrix, mainly type I collagen, in the dermis [23]. Similarly, other studies have reported variable prevalence of eyelid changes ranged from 29 to 65% of patients [5,24]. In this study, Telangiectasia was observed in 36% of patients which is lower than that found in Gomes et al study (51.1 %) [25].…”

Section: Discussioncontrasting

confidence: 48%

“…Many ocular manifestations of SSc have been described, some being well-known associations and others reported for the first time in case reports [5]. Eyelid skin changes,Telangiectasia [6].…”

Section: Introductionmentioning

confidence: 99%

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Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Jawad¹,

Gorial²

2017

IOSR JNHS

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 48%

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Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Jawad¹,

Gorial²

2017

IOSR JNHS

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“…2 The most common ocular findings are keratoconjunktivitis sicca, eyelid skin fibrosis, anterior uveitis, normal tension glaucoma, optic neuropathy, and choroidopathy. [3][4][5][6] Choroid is a vascular structure of the eye that supplies oxygen and metabolites to the outer segment of the retina. 7 Enhanced depth imaging optical coherence tomography (EDI-OCT) technologies provide accurate quantitative analysis of the choroid tissue.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of choroidal thickness in patients with scleroderma

Coşkun

Zengin

Kenan

et al. 2016

Eye

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Purpose To investigate the choroidal thickness in patients with scleroderma and to compare them with healthy control subjects. Methods Forty-six patients with scleroderma (3 male and 43 female) and 31 healthy controls (6 male and 25 female) were included in the study. Twenty-five patients had limited-type and 21 patients had diffuse-type scleroderma. Only left eyes of the patients and control subjects were used in the analysis. Demographic features of all the patients and control subjects were recorded. Each subject underwent ophthalmological examinations including refraction, visual acuity, intraocular pressure, axial length (AXL) measurement, slit-lamp biomicroscopy, and fundus examination. Body mass index (BMI) was estimated for all participants. Results There were no significant differences between the patients with scleroderma and the control subjects in terms of age, gender, BMI, mean AXL, and mean spherical equivalent refractive error (SE) (P = 0.1, P = 0.086, P = 0.37, P = 0.55, and P = 0.072 respectively). The patients with scleroderma had significantly thinner nasal, temporal, and subfoveal choroid than the healthy control subjects (P 1 = 0.012, P 2 = 0.046, and P 3 o0.001, respectively). There were no significant differences between the patients with limited-type and diffuse-type scleroderma in terms of age, gender, BMI, mean AXL, mean SE, nasal, temporal, and subfoveal choroidal thicknesses (all P40.05). Conclusions Choroidal thickness in patients with scleroderma was significantly less than healthy control subjects. Vasculopathy in scleroderma is characterized by obliteration of arterioles and reduced capillary density may cause atrophy of choroid in patients with scleroderma.

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“…One of the most frequent ocular features of SSc is dry eye disease (DED), which has been identified to occur in 37-79% of patients and is thought to be derived from fibrosis of the conjunctiva and lacrimal gland, which leads to a tear deficiency state that causes further damage to the ocular surface [4,5]. Although the probability of dry eye causing blindness or visual impairment is low, it has a significant impact on the daily and social lives of patients [6,7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dry eye signs and symptoms in patients with systemic sclerosis

Gomes

Santhiago

Azevedo

et al. 2012

Graefes Arch Clin Exp Ophthalmol

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Background One of the most frequent ocular features of systemic sclerosis (SSc) is dry eye disease (DED), which has been identified to occur in 37-79% of patients.Although several studies have found weak or no correlations between symptoms and signs of dry eye, symptoms are often the motivation for seeking eye care, and are therefore a critical outcome measure when assessing treatment effect. The aim of this study is to evaluate the impact of symptoms of dry eye on vision-related quality of life in patients with systemic sclerosis, and to investigate the relation between clinical tests and symptoms of dry eye in these patients. Methods In this cross-sectional study, 45 consecutive patients with SSc were enrolled. For evaluation of the symptoms the "Ocular Surface Disease Index (OSDI)" questionnaire was applied to all patients. After that, all individuals were submitted to a full ophthalmic examination, including the following tests: tear break-up time, Schirmer I, rose bengal staining. Patients were then grouped into dry eye and non-dry eye groups with regard to the diagnosis of dry eye. Mann-Whitney test was used to compare continuous variables, whereas the Fisher exact test was used to compare categorical data between groups. Spearman's correlation test was used to analyze the correlations between clinical tests and OSDI scores. P values <0.05 were considered significant. Results Dry eye disease was diagnosed in 22 patients (48.9%). Other ocular surface abnormalities found were: blepharitis (40% of the patients), pterygium (15.6%), pinguecula (82.2%), and superficial punctate keratitis (26.7%). Among the 45 patients, 29 patients (64.4%) had symptoms of ocular surface disease. The mean OSDI score was 26.8±25.8 (SD). There were no statistically significant differences in OSDI scores between DED and non-DED patients. No substantive correlations were found between OSDI scores and TBUT, Schirmer I, or rose bengal staining score, and none of the observed correlations reached statistical significance. Conclusion Symptoms of dry eye have a moderate impact on vision-related quality of life in patients with systemic sclerosis and do not correlate well with clinical findings.

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Ocular Manifestations of Scleroderma

Cited by 76 publications

References 73 publications

Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Ocular Manifestations of Systemic Sclerosis:A Descriptive CrossSectional Study from Iraq

Evaluation of choroidal thickness in patients with scleroderma

Evaluation of dry eye signs and symptoms in patients with systemic sclerosis

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