Ocular manifestations of rheumatoid arthritis

Reddy, Amit K.; Kolfenbach, Jason R.; Palestine, Alan G.

doi:10.1097/icu.0000000000000890

Cited by 8 publications

(11 citation statements)

References 53 publications

(65 reference statements)

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“…Our results are concordance with some studies [9,13] , and different from others [10,14] . This may be explained by different ethnic population and environmental factors [14] .…”

Section: Discussionsupporting

confidence: 92%

Eye involvement in patients with rheumatoid arthritis: a cross-sectional study

Obaid Hassnah,

Haidar,

Kudsi

et al. 2024

International Journal of Surgery: Global Health

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Background: Rheumatoid arthritis (RA) is a systemic immune disease. The authors aimed to report the characteristics of ocular manifestations in patients with RA. Methods: Demographic and clinical characteristics were collected including: age, sex, and BMI. Disease data included the duration, the present main complaint, including the number of painful and swollen joints, duration of morning stiffness, and the patient’s self-evaluation form had also been applied and registered. Eye symptom including pain, dryness, redness, photophobia, discharge, and blurred vision was asked and registered, in addition to full medical history, treatment, and evaluation of clinical disease activity index. Rheumatologic examination included: the number of tender and swollen joints in patients was done. All study subjects underwent complete ophthalmological examination in the following manner: visual acuity assessment by Snellen’s chart, evaluation of pupil diameter and reflexes as well as eyeball movements, tear film evaluation by using Schirmer’s test, intraocular pressure measurement, slit-lamp evaluation of the anterior segment with concentration on ocular surface assessment, followed by installation of topical mydriatic/cycloplegic eyedrops for posterior eye segment exam and fundoscopy. Laboratory tests included rheumatic factor, anti cytoplasmic citrulinted peptide, C-reactive protein, and erythrocyte sedimentation rate were performed and analyzed. Results: Mean age of study group was 41.5±10 years,78.59% of which were females. Ocular manifestations were present in 31.14%. Dry eye was diagnosed in (36.71%), among which burning sensation was found in (35.15%), and photophopia in (27.34%). The most frequent ocular manifestation was episcleritis (66.40%), while scleritis was diagnosed in (22.65%), and keratoconjuctivitis was present in (7.04%). Discussion: The most common manifestations of ocular involvement in our RA patients was episcleritis, dry eye, and scleritis. Positive serum rheumatoid factor and anticitrulinated peptide antibody significantly increased the risk of having ocular manifestations, especially dry eyes, and the ocular manifestations prevalence was higher among male patients, long disease duration and treatment with biologics and disease-modifying antirheumatic drugs. Conclusion: Ocular symptoms are relatively frequent manifestation of RA. Regular ophthalmological examinations are essential among patients with RA.

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“…Our results are concordance with some studies [9,13] , and different from others [10,14] . This may be explained by different ethnic population and environmental factors [14] .…”

Section: Discussionsupporting

confidence: 92%

Eye involvement in patients with rheumatoid arthritis: a cross-sectional study

Obaid Hassnah,

Haidar,

Kudsi

et al. 2024

International Journal of Surgery: Global Health

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“…In diabetic retinopathy (DR), the levels of specific cytokines in ocular fluids can serve as indirect indicators of glucose regulation 38 . Autoimmune diseases like systemic lupus erythematosus and rheumatoid arthritis can manifest ocular symptoms, which can be diagnosed through markers in ocular fluids 39,40 . The integration of genomics, proteomics, and transcriptomics, known collectively as ‘omics,’ presents opportunities to identify genetic and protein signatures in the eye that relate to systemic conditions, potentially revolutionizing diagnostic and therapeutic approaches 37 …”

Section: Physiologic Basis For Systemic Disease Diagnosis Using Ocula...mentioning

confidence: 99%

“…diagnosed through markers in ocular fluids. 39,40 The integration of genomics, proteomics, and transcriptomics, known collectively as 'omics,' presents opportunities to identify genetic and protein signatures in the eye that relate to systemic conditions, potentially revolutionizing diagnostic and therapeutic approaches. 37 3 | OPHTHALMIC IMAGE MODALITIES FOR SYSTEMIC DISEASE PREDICTION…”

Section: Other Shared Factorsmentioning

confidence: 99%

Advancing systemic disease diagnosis through ophthalmic image‐based artificial intelligence

Miao,

Zou,

et al. 2024

MedComm – Future Medicine

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The eye serves as a unique window into systemic health, offering clinicians a valuable opportunity for early detection and targeted treatment. Against this backdrop, advancements in artificial intelligence (AI) and ophthalmic imaging are converging to pave the way for more precise and predictive diagnostics. This review aims to elucidate the transformative role of AI in utilizing ophthalmic imaging for the detection and prediction of systemic diseases. We begin by introducing the advantages of the eye as a valuable tool for detecting systemic diseases. We also provide an overview of various ophthalmic imaging techniques that have proven useful in predicting systemic ailments. Then, we summarize two research patterns for analyzing ocular data, followed by the introduction of current AI applications using ophthalmic images that significantly increase diagnostic precision. Despite the promise, challenges such as data heterogeneity and model interpretability persist, which are also covered in this review. We conclude by discussing future directions and the immense potential these AI‐enabled approaches hold for revolutionizing healthcare. As AI technologies advance, their potential integration with ophthalmic imaging offers promising avenues for improving the diagnosis, prediction, and management of various systemic diseases, thereby contributing to the evolving landscape of integrated healthcare.

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“…Although a part of EAM was initially included into the early RA classification criteria [6] and that EAMs are currently part of RA assessment [1], their management is still underweighted due to the lack of specific guidelines [2,7 & ]. The ocular EAMs are not rare, with an incidence of 27-39% [8][9][10], and it can be as high as 90% in certain populations [11]. The probability of ocular involvement increases in long-standing disease, and it may represent the main clinical manifestation of RA [7 ,10].…”

Section: Introductionmentioning

confidence: 99%

“…The ocular EAMs are not rare, with an incidence of 27–39% [8–10], and it can be as high as 90% in certain populations [11]. The probability of ocular involvement increases in long-standing disease, and it may represent the main clinical manifestation of RA [7 ▪ ,10].…”

Section: Introductionmentioning

confidence: 99%

Corneal complications of rheumatoid arthritis

Wajnsztajn

Nche

Solomon

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewRheumatoid arthritis (RA) is an autoimmune disease that primarily affects the joints. Extra-articular manifestations (EAMs) are common and may affect up to 40.6% of patients. Ocular EAM can occur in 39% of the patients. The cornea is involved by different pathogenic mechanisms and corneal disease varies from mild symptoms to severe corneal ulceration and melting with visual loss. Severe corneal involvement is associated with increased mortality in RA patients. We aimed to review the prevalence, mechanisms, management and overall impact of corneal involvement in RA patients.Recent findingsCorneal involvement is frequent among RA patients. With the wider use of systemic immunosuppression, in particular the disease-modifying antirheumatic drugs (DMARDs), and with improvement of surgical techniques, spontaneous and surgery-related corneal ulceration and melting is becoming less common. However, RA patients are still at risk and should be carefully managed.SummaryRA-related corneal complications are associated with a decreased quality of life and poor ocular and systemic prognosis. Prompt recognition and a multidisciplinary approach involving topical ophthalmic management and systemic immunosuppression are the key factors to maintain ocular integrity and avoid a lethal outcome.

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Ocular manifestations of rheumatoid arthritis

Cited by 8 publications

References 53 publications

Eye involvement in patients with rheumatoid arthritis: a cross-sectional study

Eye involvement in patients with rheumatoid arthritis: a cross-sectional study

Advancing systemic disease diagnosis through ophthalmic image‐based artificial intelligence

Corneal complications of rheumatoid arthritis

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