Ocular Manifestations of Hospitalized Patients with COVID-19 in Northeast of Iran

Abrishami, Mojtaba; Tohidinezhad, Fariba; Daneshvar, Ramin; Omidtabrizi, Arash; Amini, Mahnaz; Sedaghat, Alireza; Amini, Shahram; Reihani, Hamidreza; Allahyari, Abolghasem; Seddigh-Shamsi, Mohsen; Tayyebi, Mohammad; Naderi, HamidReza; Bojdy, Amin; Khodashahi, Rozita; Eslami, Saeid

doi:10.1080/09273948.2020.1773868

Cited by 71 publications

(78 citation statements)

References 6 publications

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“…9 Reports on the ocular manifestations of COVID-19 mostly describe anterior segment disorders including conjunctival congestion, chemosis and conjunctivitis. 10,11 Reports of the retinal findings are rare. One group from Brazil 12 described various retinal complications of COVID-19 but the validity of this study has been called into question.…”

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confidence: 99%

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

Abrishami

Emamverdian

Shoeibi

et al. 2021

Canadian Journal of Ophthalmology

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127

133

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Objective To quantify the density of the macular microvasculature and the area of the foveal avascular zone (FAZ) in patients recovered from Coronavirus Disease 2019 (COVID-19) using optical coherence tomography angiography (OCTA) analysis. Methods In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included in this study. All included subjects exhibited a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Spectral domain macular OCTA was performed at least 2 weeks after recovery from systemic COVID-19. Vessel density (VD) of the superficial (SCP) and deep retinal capillary plexus (DCP) and the area of the FAZ were measured in COVID-19 recovered patients versus age-matched normal controls. Results Thirty-one recovered COVID-19 patients and 23 healthy normal controls were studied. Mean quality scan index was 7.64±0.66 in the COVID cases and 8.34±0.71 in the normal controls (p=0.001). Mean SCP VD and DCP VD of the COVID cohort was significantly lower than the SCP VD and DCP VD of the control group in the foveal and parafoveal regions. FAZ area was greater in the COVID cohort, but this difference was not statistically significant. In addition, in the COVID cohort, VD of the SCP and DCP were lower in patients with a history of COVID-19 hospitalization versus those without such a history but this did not reach statistical significance. Conclusion Patients recovered from COVID-19 displayed alterations in the retinal microvasculature including a significantly lower VD in the SCP and DCP. Patients with coronavirus infection may be at risk of retinal vascular complications.

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mentioning

confidence: 99%

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

Abrishami

Emamverdian

Shoeibi

et al. 2021

Canadian Journal of Ophthalmology

Self Cite

127

133

View full text Add to dashboard Cite

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“…Therefore, SARS-CoV-2 might have a significant causative influence on these ocular symptoms, making further prospective studies comparing the clinical ocular involvement of outpatients and inpatients a high priority. Eventually, the presence of clinical ocular manifestations in individuals with COVID-19 might be a negative predictor of outcome [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

More than loss of taste and smell: burning watering eyes in coronavirus disease 2019

Rokohl

Loreck

Matos

et al. 2020

Clinical Microbiology and Infection

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Objectives To evaluate ocular symptoms in European non-hospitalized patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and to investigate associations with the demographic data as well as nasal and general physical symptoms. Methods In this prospective, observational study, 108 non-hospitalized patients with PCR-confirmed SARS-CoV-2 infection not requiring intensive care were asked about disease-associated ocular symptoms, demographic data, as well as general physical and nasal symptoms using a standardized questionnaire. Total ocular symptom score (TOSS) was evaluated during and, retrospectively, before development of coronavirus disease 2019 (COVID-19). Associations between TOSS and demographic data as well as general and nasal symptoms were evaluated. Results Seventy-five of the 108 COVID-19 patients (69.4%) had at least one ocular symptom during COVID-19. The most common symptoms included burning sensations in 39 (36.1%), epiphora in 37 (34.3%) and redness in 28 (25.9%), compatible with conjunctivitis. These symptoms occurred 1.96 ± 3.17 days after the beginning of COVID-19 and were mild. TOSS was significantly higher during COVID-19 (1.27 ± 1.85) than before the infection (0.33 ± 1.04; p < 0.001). There were no significant associations between TOSS and gender (β coefficient –0.108; p 0.302), age (–0.024; p 0.816), rhinorrhoea (–0.127; p 0.353), nasal itching (–0.026; p 0.803), sneezing (0.099; p 0.470), nasal congestion (–0.012; p 0.930), cough (–0.079; p 0.450), headache (0.102; p 0.325), sore throat (0.208; p 0.052), or fever (0.094; p 0.361). Conclusions Ocular involvement in European non-hospitalized individuals with COVID-19 seems to be highly underestimated. Overall, these ocular symptoms, including burning sensations, epiphora and redness, seem to be mild and to not need treatment.

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“…A total of 69 of these patients had visible ocular findings and there were significantly more ocular findings in the ICU group than the non-ICU group. None of the patients developed ocular symptoms prior to systemic involvement [17]. Similarly, Poddar et al described the case of a 65-year-old man who presented to the hospital after having 3 weeks of rhinorrhea, cough, and dyspnea.…”

Section: At-risk Populations For Sars-cov-2 Outbreakmentioning

confidence: 98%

Update and Recommendations for Ocular Manifestations of COVID-19 in Adults and Children: A Narrative Review

Danthuluri

Grant

2020

Ophthalmol Ther

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The coronavirus disease 2019 (COVID-19) pandemic has instigated severe global turmoil both medically and socioeconomically. Research continues to rapidly develop in order to fully comprehend the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study focuses on the rare ophthalmologic manifestations of the SARS-CoV-2 disease process in both adults and children. There is evidence to suggest that viral transmission can occur via tears and conjunctival secretions, although it is not a predominant finding. This review considers all the published studies describing ocular findings and SARS-CoV-2 viral transmission through the eye. The review addresses the ongoing debate over the importance of ocular manifestations during this pandemic. The most updated safety guidelines, protocols, timelines of ocular manifestations during the disease course, and treatment recommendations are discussed. The majority of patients with COVID-19 with eye symptoms presented with them initially. It is possible that the virus becomes inoculated at the site of the eye and spreads via the nasolacrimal duct to the respiratory system. There are also some reports which show that ocular findings present later in the disease course, suggestive of a correlation between ocular manifestation and increased disease severity as the infection becomes systemic. We highlight the importance of recognizing conjunctivitis as an early finding of COVID-19, and that testing or appropriate follow-up could be beneficial in both the pediatric and adult populations.

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Ocular Manifestations of Hospitalized Patients with COVID-19 in Northeast of Iran

Cited by 71 publications

References 6 publications

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

More than loss of taste and smell: burning watering eyes in coronavirus disease 2019

Update and Recommendations for Ocular Manifestations of COVID-19 in Adults and Children: A Narrative Review

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