Ocular Manifestations in Patients with HIV infection

Linzerová, Dominika; Stepanov, Alexandr; Němčanský, Jan

doi:10.31348/2018/6/3

Cited by 6 publications

(7 citation statements)

References 4 publications

(5 reference statements)

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“…In addition, the direct pathogenic effect of HIV has been implicated in the occurrence of a few cases of acute retinal necrosis diagnosed during this survey. It is true that herpes viruses can also be responsible for acute retinal necrosis [4,11]. The insufficiency of our laboratories has not made it possible to make a genomic diagnosis by PCR on vitreous samples.…”

Section: Discussionmentioning

confidence: 99%

“…Either by direct action, the virus is responsible for damage to the eye and its related structures. Either indirectly, the virus induces a state of immunosuppression conducive to the action of other types of socalled opportunistic viruses [4,5]. This work had a double objective, to describe the clinical aspects of the viral ocular pathology in Brazzaville and to state the principles of the antiviral treatments used.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Therapeutic Aspects of Viral Ocular Pathology in Brazzaville

2020

JOCR

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Introduction: Viruses can act in two ways, either by a direct pathogenic effect, or indirectly by inducing immunosuppression and favoring the action of other so-called opportunistic viruses. This survey had a double objective, describe the clinical aspects of viral ocular pathology and state its principles of treatment. Materials and Methods: Descriptive cross-sectional study carried out over 2 years at the Ophthalmology department of the University Hospital of Brazzaville. Patients 18 years of age or older with viral ocular pathology were included. The diagnosis was made on the sole basis of anamnestic and / or clinical arguments. None of the viruses involved had been directly detected, with the exception of HIV. Biologically proven patients with a coinfection (bacteria, parasite, fungus) were excluded. HIV serology had been systematic. Four parameters were analyzed: type of virus, structures affected, pathologies diagnosed, anti viral treatments used. Results: Two hundred twenty-five (225) patients were included. The mean age was 44 ± 2.1 years. Sex ratio was 0.8. Viruses: Adenovirus (51.1%), Herpes zoster (19.5%), HIV (18.7%), Herpes simplex (7.5%), CMV (3.2%). Main structures affected: eyelid (86.2%), chorioretin (6.4%). Main pathologies: Adenovirus conjunctivitis (61.1%), shingles (16%), primary herpes simplex infection (8%) Keratitis (6.4%), chorioretinitis (6.4%), uveitis (2.1%). Anti viral treatments used: Valaciclovir, Ganciclovir and anti retroviral. Conclusion: Viral ocular pathology is dominated by Adenovirus conjunctivitis and infections due to 3 types of herpes viridae (Herpes zoster, Herpes simplex and CMV). These herpes viridae are generally responsible for opportunistic diseases following immunosuppression linked to HIV.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and Therapeutic Aspects of Viral Ocular Pathology in Brazzaville

2020

JOCR

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“…These were Cytomegalovirus (CMV) and Herpes zoster. These Herpes viridae are the cause of certain opportunistic diseases [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Reactivation of CMV during HIV infection always reflects a state of deep immunosuppression with a CD4 cell count which is less than 50 / mm3 [4,6].…”

Section: Discussionmentioning

confidence: 99%

“…Herpes zoster has been responsible for 3 types of disease, namely, ophthalmic shingles, keratitis, and acute hypertensive anterior uveitis. It is recognized that ophthalmic shingles is often the inaugural disease of HIV/AIDS [4,9,10]. However, no direct link has yet been demonstrated between HIV-related immunosuppression and the 2 other pathologies due to Herpes zoster, notably keratitis and acute hypertensive anterior uveitis [4,11].…”

Section: Discussionmentioning

confidence: 99%

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2019

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Isolated Kaposi’s Sarcoma of the Bulbar Conjunctiva as an Initial Manifestation of AIDS: A Case Report

Alsawadi,

Al-Somali,

Najmi

et al. 2023

Case Rep Ophthalmol

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Kaposi’s sarcoma (KS) is a malignant vascular endothelium-cell-derived tumor caused by human herpesvirus 8. It is one of the most common tumors among human immunodeficiency virus (HIV)-infected patients; however, isolated KS is rarely reported as the initial presentation. This study describes a rare case in which isolated KS of the bulbar conjunctiva was the first presenting symptom leading to the diagnosis of HIV/acquired immunodeficiency syndrome (AIDS) in a 39-year-old man. The patient, who had no prior medical history, presented to the ophthalmology clinic with an isolated large, dark-reddish mass in the left bulbar conjunctiva and subconjunctival hemorrhage. The mass was first identified 6 months prior and had continued to grow since then. KS was confirmed based on the analysis of the incisional biopsy sample, subsequently prompting an HIV test, which was positive. This report highlights the recognition of KS as a relevant ocular complication and potential initial manifestation of AIDS. Additionally, KS should be considered in the differential diagnosis of any vascular lesion, even when present at uncommon sites.

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Ocular Manifestations in Patients with HIV infection

Cited by 6 publications

References 4 publications

Clinical and Therapeutic Aspects of Viral Ocular Pathology in Brazzaville

Clinical and Therapeutic Aspects of Viral Ocular Pathology in Brazzaville

Untitled

Isolated Kaposi’s Sarcoma of the Bulbar Conjunctiva as an Initial Manifestation of AIDS: A Case Report

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