Ocular manifestations in celiac disease: an overview

Fousekis, Fotios S.; Katsanos, Andreas; Κατσάνος, Κωνσταντίνος; Christodoulou, Dimitrios

doi:10.1007/s10792-019-01254-x

Cited by 24 publications

(23 citation statements)

References 64 publications

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“…While some cases of improved uveitis in CD patients following a GFD have been described [1], this report, to the best of our knowledge, is the first description of a GFD-dependent improvement of TAO along with the disappearance of TRAb. This finding supports the hypothesis that gastrointestinal immune dysfunction may have reversible extraintestinal consequences [2,4].…”

mentioning

confidence: 62%

“…CD is now recognized as being symptomless (occult CD) in many cases, but almost half of all patients with CD present extraintestinal manifestations, including some ophthalmic disorders (e.g., nyctalopia, TAO, and uveitis) [1]. Of note, transglutaminase, the gluten catabolic enzyme, has been described in thyroid tissue and the binding of anti-tTGAb may trigger inflammation and thyroid dysfunction [2].…”

mentioning

confidence: 99%

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Unilateral Thyroid-Associated Orbitopathy as the Only Sign of Occult Celiac Disease: Effective Treatment with a Gluten-Free Diet

2021

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confidence: 62%

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confidence: 99%

Unilateral Thyroid-Associated Orbitopathy as the Only Sign of Occult Celiac Disease: Effective Treatment with a Gluten-Free Diet

2021

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“…Celiac disease is an autoimmune disease with systemic involvement that mainly affects the small intestine, but it also presents several extraintestinal manifestations 3 . Among these, the eye certainly represents one of the target organs of the disease, and night blindness, dry eye, cataract, thyroid-associated orbitopathy, uveitis, central retinal vein occlusion and neuro-ophthalmic manifestations may occur 24 .…”

Section: Discussionmentioning

confidence: 99%

Choroidal structural evaluation in celiac disease

Bernardo

Battipaglia

Mascolo

et al. 2021

Sci Rep

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This observational case–control study assessed the differences in choroidal structure between patients with celiac disease and healthy subjects utilizing the choroidal vascularity index (CVI). Seventy-four celiac patients and 67 healthy subjects underwent a complete ophthalmological evaluation, axial length (AL) measurements and spectral-domain optical coherence tomography with enhanced depth imaging mode (EDI SD-OCT) evaluation. These images were binarized and choroidal vasculature was analyzed. Choroidal total subfoveal area (TSA), luminal subfoveal area (LSA), stromal subfoveal area (SSA), CVI and subfoveal choroidal thickness (CT) were measured. Furthermore, subfoveal CT, TSA, LSA, SSA, and CVI were also correlated with AL. A statistically significant difference was found between the two groups for TSA, LSA, SSA and subfoveal CT, but not for CVI. In celiac patients, a significant correlation was found between AL and TSA, LSA and SSA, but not with CVI. Similar findings were also noticed in the healthy subjects. Thus, celiac patients have a thicker choroid than healthy subjects, regardless of the AL, due to a proportional increase in both the vascular and stromal components, which does not alter the CVI.

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“…Celiac disease is a chronic disease of the small intestine affecting 1 – 2% of the global population ( 47 ), and is triggered by long-term ingestion of gluten. Moreover, up to 15% of celiac patients have Sjogren’s syndrome as a secondary autoimmune disease ( 48 ), increasing the risk of ocular problems.…”

Section: Autoimmune Disorders and Their Ocular Effectsmentioning

confidence: 99%

Epidemiology of Ocular Manifestations in Autoimmune Disease

2021

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The global prevalence of autoimmune diseases is increasing. As a result, ocular complications, ranging from minor symptoms to sight-threatening scenarios, associated with autoimmune diseases have also risen. These ocular manifestations can result from the disease itself or treatments used to combat the primary autoimmune disease. This review provides detailed insights into the epidemiological factors affecting the increasing prevalence of ocular complications associated with several autoimmune disorders.

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Ocular manifestations in celiac disease: an overview

Cited by 24 publications

References 64 publications

Unilateral Thyroid-Associated Orbitopathy as the Only Sign of Occult Celiac Disease: Effective Treatment with a Gluten-Free Diet

Unilateral Thyroid-Associated Orbitopathy as the Only Sign of Occult Celiac Disease: Effective Treatment with a Gluten-Free Diet

Choroidal structural evaluation in celiac disease

Epidemiology of Ocular Manifestations in Autoimmune Disease

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