Ocular involvement in nasal natural killer T-cell lymphoma

Abstract

Purpose-To describe the clinical, morphologic, and immunohistochemical features of a case of paranasal natural killer/T-cell lymphoma (NKTL) with ocular involvement.

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

“…Like other non-Hodgkin lymphomas, it can masquerade as an intraocular inflammatory or infectious process [3], which can lead to delayed diagnosis and vision loss. The prognosis for ENKTCL is substantially worse than that of other T-cell or B-cell lymphomas [4], especially if patients present late or if there is orbital or ocular adnexal involvement [2, 5]. Early diagnosis is thus of utmost importance, but can prove quite challenging.…”

“…Previous studies have documented orbital/ocular adnexal involvement of ENKTCL, both as a primary [5-10] and secondary [4, 10-13] manifestation of the disease. Intraocular involvement is quite rare with only a small number of published cases [4, 14-16]. To our knowledge, we are the first to report a case of ENKTCL metastatic to the space beneath the retinal pigment epithelium (RPE).…”

Ocular masquerade syndrome associated with extranodal nasal natural killer/T-cell lymphoma: case report

“…Some authors (9,10) did report a case of histologically confirmed nasal NKTL with intraocular involvement, as well as Yoo et al, (11) . In a large series of 24 cases with primary nasal and paranasal sinus NKTL, six patients suffered from vision threatening complications of uveitis/ vitritis and orbital involvement, including one with rhegmatogenous retinal detachment and one with macular hole (12) .…”

Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome

“…T-cell IOL in the past 19,22,25 and two SRD cases were recently described on T-cell IOL. 29,30 A low rate of SRD was previously reported in B-cell lymphoma (10-28%).…”