Ocular involvement in Multiple Myeloma

Bronstein, Melvin

doi:10.1001/archopht.1956.00930030190004

Cited by 26 publications

(6 citation statements)

References 7 publications

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“…83 Bronstein and colleagues were the first to discover aggregates of plasma cells in the iris and choroid. 81 Knapp and colleagues further found bilateral microcysts of the iris pigment epithelium in 6 of the 11 myeloma patients included in their study. 84 These cysts are often observed without direct malignant ocular involvement, but the electrophoresis of their aspirate resembles the serum electrophoresis of myeloma patients.…”

Section: Multiple Myelomamentioning

confidence: 88%

“…21,74,80 The sclera can be colonized by direct myeloma cell infiltrates in metastatic disease and plasma cell leukemia. 81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic "T-sign", but blood tests for myeloma clinch the diagnosis.…”

Section: Multiple Myelomamentioning

confidence: 99%

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Ocular complications of plasma cell dyscrasias

Singh

Singhal

Sinha

et al. 2023

European Journal of Ophthalmology

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Plasma cell dyscrasias are a wide range of severe monoclonal gammopathies caused by pre-malignant or malignant plasma cells that over-secrete an abnormal monoclonal antibody. These disorders are associated with various systemic findings, including ophthalmological disorders. A search of PubMed, EMBASE, Scopus and Cochrane databases was performed in March 2021 to examine evidence pertaining to ocular complications in patients diagnosed with plasma cell dyscrasias. This review outlines the ocular complications associated with smoldering multiple myeloma and monoclonal gammopathy of undetermined significance, plasmacytomas, multiple myeloma, Waldenström's macroglobulinemia, systemic amyloidosis, Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes (POEMS) syndrome, and cryoglobulinemia. Although, the pathological mechanisms are not completely elucidated yet, wide-ranging ocular presentations have been identified over the years, evolving both the anterior and posterior segments of the eye. Moreover, the presenting symptoms also help in early diagnosis in asymptomatic patients. Therefore, it is imperative for the treating ophthalmologist and oncologist to maintain a high clinical suspicion for identifying the ophthalmological signs and diagnosing the underlying disease, preventing its progression through efficacious treatment strategies.

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Section: Multiple Myelomamentioning

confidence: 88%

Section: Multiple Myelomamentioning

confidence: 99%

Ocular complications of plasma cell dyscrasias

Singh

Singhal

Sinha

et al. 2023

European Journal of Ophthalmology

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“…Há relatos de casos na literatura de pacientes com mieloma múltiplo que desenvolveram alterações retinianas; porém, geralmente os pacientes correspondem a faixas etárias mais elevadas. Em uma revisão, foram encontrados casos de pacientes com idades que variavam entre 38 e 76 anos (3,(6)(7)(8)(9)(10)(11)(12)(13) .…”

Section: Discussionunclassified

Trombose de veia central da retina bilateral associada à síndrome de hiperviscosidade sanguínea: relato de caso

Helal¹,

Malerbi²,

Filho³

2005

Arq. Bras. Oftalmol.

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The authors report the case of a 16-year-old male patient who presented with blurred vision and bilateral optic disc edema, then developing bilateral central retinal vein occlusion. On laboratory work-up, he was found to have multiple myeloma IgA along with hyperviscosity syndrome, which led to the ophthalmological features. After proper treatment, the patient recovered visual acuity and normalized his eye fundus changes. Bilateral central retinal vein occlusion finding may yield the diagnosis of major systemic diseases. Fundoscopic features may serve as parameters on treatment evaluation.

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“…[1][2][3] Direct infiltration of plasma cells into the eye is exceedingly rare. Here, we report a case of abnormal plasma cell infiltration in the eye of a patient with myeloma, which presented as a pseudohypopyon.…”

mentioning

confidence: 99%