Ocular involvement in Multiple Myeloma

Ocular complications of plasma cell dyscrasias

“…83 Bronstein and colleagues were the first to discover aggregates of plasma cells in the iris and choroid. 81 Knapp and colleagues further found bilateral microcysts of the iris pigment epithelium in 6 of the 11 myeloma patients included in their study. 84 These cysts are often observed without direct malignant ocular involvement, but the electrophoresis of their aspirate resembles the serum electrophoresis of myeloma patients.…”

“…21,74,80 The sclera can be colonized by direct myeloma cell infiltrates in metastatic disease and plasma cell leukemia. 81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic "T-sign", but blood tests for myeloma clinch the diagnosis.…”

“…81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic “T-sign”, but blood tests for myeloma clinch the diagnosis. The management consists primarily of steroids with a long tapering course.…”

Ocular complications of plasma cell dyscrasias

“…83 Bronstein and colleagues were the first to discover aggregates of plasma cells in the iris and choroid. 81 Knapp and colleagues further found bilateral microcysts of the iris pigment epithelium in 6 of the 11 myeloma patients included in their study. 84 These cysts are often observed without direct malignant ocular involvement, but the electrophoresis of their aspirate resembles the serum electrophoresis of myeloma patients.…”

“…21,74,80 The sclera can be colonized by direct myeloma cell infiltrates in metastatic disease and plasma cell leukemia. 81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic "T-sign", but blood tests for myeloma clinch the diagnosis.…”

“…81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic “T-sign”, but blood tests for myeloma clinch the diagnosis. The management consists primarily of steroids with a long tapering course.…”

Trombose de veia central da retina bilateral associada à síndrome de hiperviscosidade sanguínea: relato de caso

“…Há relatos de casos na literatura de pacientes com mieloma múltiplo que desenvolveram alterações retinianas; porém, geralmente os pacientes correspondem a faixas etárias mais elevadas. Em uma revisão, foram encontrados casos de pacientes com idades que variavam entre 38 e 76 anos (3,(6)(7)(8)(9)(10)(11)(12)(13) .…”

Pseudohypopyon due to malignant infiltration of the anterior chamber in multiple myeloma

“…[1][2][3] Direct infiltration of plasma cells into the eye is exceedingly rare. Here, we report a case of abnormal plasma cell infiltration in the eye of a patient with myeloma, which presented as a pseudohypopyon.…”

Ocular complications of plasma cell dyscrasias

“…83 Bronstein and colleagues were the first to discover aggregates of plasma cells in the iris and choroid. 81 Knapp and colleagues further found bilateral microcysts of the iris pigment epithelium in 6 of the 11 myeloma patients included in their study. 84 These cysts are often observed without direct malignant ocular involvement, but the electrophoresis of their aspirate resembles the serum electrophoresis of myeloma patients.…”

“…21,74,80 The sclera can be colonized by direct myeloma cell infiltrates in metastatic disease and plasma cell leukemia. 81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic "T-sign", but blood tests for myeloma clinch the diagnosis.…”

“…81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic “T-sign”, but blood tests for myeloma clinch the diagnosis. The management consists primarily of steroids with a long tapering course.…”

Trombose de veia central da retina bilateral associada à síndrome de hiperviscosidade sanguínea: relato de caso

“…Há relatos de casos na literatura de pacientes com mieloma múltiplo que desenvolveram alterações retinianas; porém, geralmente os pacientes correspondem a faixas etárias mais elevadas. Em uma revisão, foram encontrados casos de pacientes com idades que variavam entre 38 e 76 anos (3,(6)(7)(8)(9)(10)(11)(12)(13) .…”

Pseudohypopyon due to malignant infiltration of the anterior chamber in multiple myeloma

“…[1][2][3] Direct infiltration of plasma cells into the eye is exceedingly rare. Here, we report a case of abnormal plasma cell infiltration in the eye of a patient with myeloma, which presented as a pseudohypopyon.…”

Ocular complications of plasma cell dyscrasias

“…83 Bronstein and colleagues were the first to discover aggregates of plasma cells in the iris and choroid. 81 Knapp and colleagues further found bilateral microcysts of the iris pigment epithelium in 6 of the 11 myeloma patients included in their study. 84 These cysts are often observed without direct malignant ocular involvement, but the electrophoresis of their aspirate resembles the serum electrophoresis of myeloma patients.…”

“…21,74,80 The sclera can be colonized by direct myeloma cell infiltrates in metastatic disease and plasma cell leukemia. 81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic "T-sign", but blood tests for myeloma clinch the diagnosis.…”

“…81 Posterior scleritis is seen with myeloma and presents as progressing, unilateral or bilateral eye pain and redness. 77,81 Non-invasive testing such as optical coherence tomography and B-scan ultrasonography can help with the diagnosis of posterior scleritis, revealing thickened sclera and a classic “T-sign”, but blood tests for myeloma clinch the diagnosis. The management consists primarily of steroids with a long tapering course.…”

Trombose de veia central da retina bilateral associada à síndrome de hiperviscosidade sanguínea: relato de caso

“…Há relatos de casos na literatura de pacientes com mieloma múltiplo que desenvolveram alterações retinianas; porém, geralmente os pacientes correspondem a faixas etárias mais elevadas. Em uma revisão, foram encontrados casos de pacientes com idades que variavam entre 38 e 76 anos (3,(6)(7)(8)(9)(10)(11)(12)(13) .…”

Pseudohypopyon due to malignant infiltration of the anterior chamber in multiple myeloma

“…[1][2][3] Direct infiltration of plasma cells into the eye is exceedingly rare. Here, we report a case of abnormal plasma cell infiltration in the eye of a patient with myeloma, which presented as a pseudohypopyon.…”