Ocular Involvement in Mantle Cell Lymphoma Detected by F 18 FDG PET/CT

Özkan, Elgin; Lacin, Seda; Soydal, Çiğdem; Araz, Mine; Küçük, N.

doi:10.4274/mirt.20.08

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…We also summarized 48 patients with MCL in the literature who presented with ocular adnexal lesions in order to elucidate their clinical features. 33 - 77 …”

Section: Introductionmentioning

confidence: 99%

Bilateral Lacrimal Gland Mantle Cell Lymphoma in 11-Year Follow-Up: Case Report and Review of 48 Cases With Ocular Adnexal Presentation in the Literature

Matsuo

Tanaka

Okada

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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A 63-year-old woman, with 11-year history of breast cancer, showed bilateral lacrimal gland enlargement on magnetic resonance imaging. Gallium-67 scintigraphy, as the standard at that time in 2004, demonstrated abnormally high uptake only in bilateral lacrimal glands. The lacrimal glands were extirpated and the pathological diagnosis was mantle cell lymphoma (MCL). She underwent bilateral orbital radiation, based on no uptake of gallium-67 in other sites of the body. In a month, bone marrow biopsy revealed the infiltration with MCL, positive for cyclin D1. She showed hepatic lymphadenopathy and splenomegaly, and so received 2 cycles of alternating Hyper-CVAD therapy and high-dose methotrexate with cytarabine, combined with rituximab, in 2 months, leading to complete remission. She underwent autologous peripheral blood stem cell transplantation and was well until the age of 68 years when she showed a recurrent intratracheal submucosal lesion of lymphoma and underwent one course of reduced-dose CHOP combined with rituximab. Next year, the left rib resection revealed the metastasis of breast adenocarcinoma, leading to daily oral letrozole. Further 2 years later, computed tomographic scan demonstrated multiple submucosal nodular lesions in the trachea and bronchi, together with cervical and supraclavicular lymphadenopathy, and intratracheal lesion biopsy and bone marrow biopsy proved the involvement with MCL. She underwent 2 courses of bendamustine and rituximab, resulting in complete remission but died of metastatic breast cancer at the age of 74 years. Clinical features in 48 previous cases with ocular adnexal MCL in the literature were summarized in this study.

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“…We also summarized 48 patients with MCL in the literature who presented with ocular adnexal lesions in order to elucidate their clinical features. 33 - 77 …”

Section: Introductionmentioning

confidence: 99%