Ocular involvement in connective tissue disorders

Young, Stephanie

doi:10.1007/s11882-005-0076-y

Cited by 11 publications

(9 citation statements)

References 34 publications

(33 reference statements)

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“…The most common systemic association with scleritis that has been reported is RA. 17,18 About one-fifth to onefourth of patients with scleritis have RA and conversely, 0.2-6.3% of RA patients suffer from scleritis. 19 Most RA patients develop articular manifestations preceding the onset of scleritis.…”

Section: Scleritismentioning

confidence: 99%

“…Complicated cataract and secondary glaucoma are frequently found in patients with scleritis, especially in those patients with severely inflamed eyes. 17 On the other hand, patients can also develop anterior scleritis without inflammation, known as scleromalacia perforans (Fig 2). Thinning of the sclera and visible uveal tissue gradually develops as a late complication of the inflammatory processes; however spontaneous perforation is rare.…”

Section: Scleritismentioning

confidence: 99%

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Ocular Manifestations in Rheumatoid Arthritis

et al. 2022

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Rheumatoid arthritis (RA) is an inflammatory rheumatic disease that generally damages synovial-line joints. Extra-articular manifestations of RA have been reported in cases of multiorgan involvement. These manifestations can occur in the hematologic and cardiovascular system, lungs, kidneys, and eyes. Various ocular manifestations of RA have been previously reported including keratoconjunctivitis sicca, conjunctivitis, uveitis, scleritis, retinal vascular occlusion, optic neuritis, and amaurosis fugax. It is important to recognize these ocular issues as manifestations of RA since they can sometimes be a response marker for the onset of an immune reactivation. Urgent management of ocular complications is essential to manage sight-threatening complications and prevent further damage to the eyes.

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Section: Scleritismentioning

confidence: 99%

Section: Scleritismentioning

confidence: 99%

Ocular Manifestations in Rheumatoid Arthritis

et al. 2022

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“…Наиболее часто встречаются кератоконъюнктивиты, кератиты, увеиты и склериты. Последние две патологии могут приводить к потере зрения [32]. Наиболее частым кожным симптомом являются ревматические узелки, которые встречаются в 20% всех внесуставных проявлений.…”

Section: патологическая активация иммунной системы на разных клиничес...unclassified

The role of homeostatic proliferation and SNP mutations in MHC genes in the development of rheumatoid arthritis

Shevyrev

Козлов

2020

Annals RAMS

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Great efforts have been made to study the etiology and pathogenesis of rheumatoid arthritis in the last few decades, but this issue remains widely unknown. In this review, we suggest a hypothesis according to which the development of rheumatoid arthritis is associated with a genetically determined enhancement of self-antigens presentation and decrease in TCR repertoire diversity due to homeostatic proliferation (HP). We suppose that qualitative changes in the TCR landscape of effector and regulatory T-cells populations lead to immune disequilibrium. I.e. HP results in the condition when self-reactive T-cell clones appear to which no specific T-regulatory cells exist. If such self-reactive clones have TCR specific to modified auto-antigens, which presentation increased due to SNP mutations in MHC genes, then the adaptive immunity is activated, and rheumatoid arthritis develops. Obviously, therapy based on the deletion of self-reactive T-cells clones involved in the RA process or on the replenishment of Treg clones by CAR-T-cells is the perspective approach of personalized medicine.

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“…The scleritis associated with SLE usually runs a fairly benign course. Immunosuppression is essential, and treatment usually entails steroid therapy in combination with immunomodulatory therapy [59]. Tectonic scleral or peripheral corneal grafting may be necessary [60].…”

Section: Anterior Eye Segment Manifestationsmentioning

confidence: 99%

Ocular Manifestations in Systemic Lupus Erythematosus

Maghsoudlou¹

2015

Rheumatology (Sunnyvale)

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Systemic lupus erythematosus (SLE) is an autoimmune disease manifest with multiple organ system involvement. Even though the eye is not part of the diagnostic criteria, once it gets affected, it will alter patients' quality of life. The purpose of this review is to point out the significance of ocular manifestations in SLE and to emphasize the importance of possible blinding complications such as peripheral ulcerative keratitis, scleritis, and SLE retinopathy/ choroidopathy. The condition can be even worse when SLE is accompanied with antiphospholipid syndrome. In addition to the disease itself, several treatment agents that are used in SLE are responsible for vision threatening conditions; thus they have to be given with caution because of potential side effects, including cataract, glaucoma, and chloroquine maculopathy.

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Ocular involvement in connective tissue disorders

Cited by 11 publications

References 34 publications

Ocular Manifestations in Rheumatoid Arthritis

Ocular Manifestations in Rheumatoid Arthritis

The role of homeostatic proliferation and SNP mutations in MHC genes in the development of rheumatoid arthritis

Ocular Manifestations in Systemic Lupus Erythematosus

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