Ocular involvement in brucellosis

Ocular involvement of brucellosis

“…In our case, antibiotic and steroid administration led to complete visual recovery and in 13 months follow-up after treatment, ophthalmologic examinations were normal. The outcome in our case is likely due to early diagnosis and treatment, lack of a drug resistant strain and better prognosis in males compared to females 1421–23. In the current case, imaging studies were normal.…”

Ocular Brucellosis: Case Report and Literature Review

“…In 1951, Pagliarani [9] published a study entitled "Contribution to the knowledge of ocular manifestations due to Brucella infection in man" in which he stated that "in these circumstances the diagnosis is less easily done and this fact makes us to believe that the incidence of ocular manifestations is more frequent than the perusal of the literature would suggest". Since then, numerous types of ocular involvement have been described, such as uveitis, dacryoadenitis, episcleritis, chronic iridoscleritis, nummular keratitis, cataract, glaucoma, multifocal choroiditis, exudative retinal detachment, maculopathy, endophthalmitis, and optic neuritis [2,6,[10][11][12][13][14] .…”

“…Any organ or system of the body can be involved, with skeletal system, spleen, liver, and bone marrow being the most frequently affected sites [1] . Ocular involvement is relatively rare, reported in 3.4-26% of cases, and is usually a complication of chronic phases of the disease [3][4][5][6][7] . Ocular brucellosis most commonly presents with uveitis; other manifestations include keratoconjunctivitis, corneal ulcers, iridocyclitis, nummular keratitis, choroiditis, optic neuritis, papilledema, and endophthalmitis [3] .…”

Infectious optic neuropathies: a clinical update

“…Although ocular involvement is uncommon in brucellosis, any ocular structure may be involved, with a broad spectrum of clinical findings, including keratitis, uveitis, choroiditis, episcleritis, endophthalmitis, dacryoadenitis, and optic neuropathy 188–200. Optic nerve involvement, including optic neuritis and papilledema, has been described in about 10% of patients with ocular brucellosis 189,192,193. It seems that optic neuropathy in brucellosis is secondary to meningeal inflammation (neurobrucellosis) and subsequent axonal degeneration 182,183.…”