Ocular Inflammatory Signs Observed in a Cohort of Spanish Patients with Behçet Disease and Ocular Inflammation

Sáenz-Francés, F.; Elías-De-Tejada, M; Martinez-de-la-Casa, José M.; Calvo-González, C; Fernandez-Vidal, Ana; Méndez-Hernández, Carmen; Pato, Esperanza; López-Abad, C; Jm, Benítez-Del-Castillo; García–Sánchez, J.; García‐Feijoó, Julián

doi:10.1177/112067210801800410

Cited by 10 publications

(9 citation statements)

References 6 publications

(14 reference statements)

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“…In studies from different parts of the world, panuveitis was reported as the most frequent ocular manifestation in patients with Behçet uveitis. 17,20,23,24 In our patients, the commonest manifestation was retinal vasculitis associated with anterior uveitis and then panuveitis. One-fifth of our patients manifested hypopyon formation at some point in their follow-up.…”

Section: Discussionmentioning

confidence: 93%

Behçet Uveitis in the American Midwest

Saleh

Birnbaum

Tessler

et al. 2012

Ocular Immunology and Inflammation

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Section: Discussionmentioning

confidence: 93%

Behçet Uveitis in the American Midwest

Saleh

Birnbaum

Tessler

et al. 2012

Ocular Immunology and Inflammation

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“…Inflammation inside the eye (uveitis and retinitis) occurs in about half of BD patients. Posterior uveitis may be dangerous, and even vision-threatening, because it often causes damage of a crucial part of the eye, the retina [31,34]. Endothelial dysfunction resulting from vascular inflammation is an important factor of thrombosis [6].…”

Section: Introductionmentioning

confidence: 99%

Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease

Ricart

España

Navarro

et al. 2013

Clinical Hemorheology and Microcirculation

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Behçet's disease (BD) is a chronic inflammatory disorder in which thrombosis and posterior ocular involvement occur in about 30% of patients, whose ethiology is unknown. It has not been established whether mean platelet volume (MPV), a marker of platelet activation, is involved in the pathogenesis of thrombotic events and posterior uveitis in these patients. We aimed to analyze whether there are differences in MPV in BD patients when compared with controls and its relation with the presence of thrombosis and posterior uveitis. We determined MPV and platelet count, along with Creactive protein (CRP) and cardiovascular risk factors (because of their influence on MPV) in 89 BD patients (of which 24 had thrombosis and 23 had posterior uveitis) and 89 sex-and age-matched healthy controls. BD patients showed statistically higher MPV than controls: 10.98 ± 1.19 fL vs. 10.60 ± 1.21 fL (P = 0.044) and higher CRP: 5.9 ± 8.9 mg/L vs. 1.4 ± 1.7 mg/L (P = 0.001). The percentage of hyperlipemia and diabetes was higher in cases than in controls (P = 0.032, P = 0.013, respectively). No differences in MPV were observed when comparing: patients with and without thrombosis: 11.8 ± 1.27 fL vs. 10.94 ± 1.28 fL (P = 0.654); with and without posterior uveitis: 10.76 ± 1.18 fL vs. 11.03 ± 1.30 fL P = 0.398; with CRP and cardiovascular risk factors (P > 0.05). MPV correlated negatively with platelet count (r = -308, P < 0.01), but not with CRP (r = -0.22, P = 0.772). MPV seems to relate to neither thrombosis nor posterior uveitis in BD patients.

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“…A predileção pelo sexo masculino varia com a região em estudo (4)(5)(6)14,(16)(17)(18)(19) . Nesse estudo, encontrou-se predileção pelo sexo feminino (81,3%), descrita também em outros estudos (18)(19)(20) .…”

Section: Discussionunclassified

“…Nesse estudo, encontrou-se predileção pelo sexo feminino (81,3%), descrita também em outros estudos (18)(19)(20) . Verifica-se pior prognóstico para sexo masculino (4,15) , relacionado ao maior ín-dice de panuveíte em homens (5) .…”

Section: Discussionunclassified

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Avaliação estrutural do polo posterior em pacientes com doença de Behçet

Corrêa¹,

Arantes²,

Lima³

et al. 2011

Arq. Bras. Oftalmol.

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Número do Projeto e Instituição responsável pelo parecer do Comitê de Ética em Pesquisa: Nº 1661/10 INTRODUÇÃOA doença de Behçet (DB), descrita em 1937 pelo dermatologista turco Hulusi Behçet, é uma desordem crônica multissistêmica com inflamação recorrente de etiologia desconhecida, provavelmente mediada por imunocomplexos(1) e de predisposição genética devido à associação com o grupo de HLA B 51. Apresenta maior prevalência em países do Mediterrâneo e Japão.A doença é diagnosticada pela presença de úlceras orais recorrentes acrescidas de pelo menos dois dos seguintes sinais: úlceras

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Ocular Inflammatory Signs Observed in a Cohort of Spanish Patients with Behçet Disease and Ocular Inflammation

Abstract: Women were slightly more affected than men, although the authors found no significant correlation between sex and the clinical variables examined. Apart from one unexpected case of intermediate uveitis, the observations are similar to those reported for other patient series.

Cited by 10 publications

References 6 publications

Behçet Uveitis in the American Midwest

Behçet Uveitis in the American Midwest

Mean platelet volume does not seem to relate to thrombosis or posterior uveitis in Behçet's disease

Avaliação estrutural do polo posterior em pacientes com doença de Behçet

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