Ocular Infections Associated With Comamonas acidovorans

Stonecipher, Karl; Jensen, Harold G.; Kastl, Peter R.; Faulkner, Alan D.; Rowsey, J. James

doi:10.1016/s0002-9394(14)76211-7

Cited by 37 publications

(17 citation statements)

References 5 publications

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“…The illness occurred soon after the patient was treated for 4 weeks with ampicillin for viridans streptococcal endocarditis. Several cases of ocular infections have been reported, including keratitis, blepharitis, and conjunctivitis in immunocompromised corneas, contact lens wearers, or otherwise healthy patients (1,11,12,17). D. acidovorans has further been reported to cause acute suppurative otitis externa and pneumonia in a patient with AIDS (5, 16).…”

Section: Acidovorans Was Formerly Called Comamonas Acidovoransmentioning

confidence: 99%

Recurrent Intravascular-Catheter-Related Bacteremia Caused by Delftia acidovorans in a Hemodialysis Patient

et al. 2011

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We report the first case of recurrent intravascular-catheter-related bacteremia in a pediatric hemodialysis patient caused by Delftia acidovorans, previously called Comamonas acidovorans or Pseudomonas acidovorans. The patient had a history of multiple infections of central vascular catheters with other organisms, requiring courses of antibiotics and catheter replacements. Previously reported cases of D. acidovorans infections are reviewed. The isolate appeared to become resistant to cephalosporins after antibiotic treatment, but resistance could not be confirmed with additional testing. In vitro susceptibility testing for cephalosporins is not reliable for this organism. CASE REPORTA 10-year-old girl with renal cortical necrosis and end-stage renal disease was receiving hemodialysis via a Quinton PermCath dual-lumen catheter for 5 years. Over this period, she had a history of 24 episodes of catheter-related infections, requiring multiple courses of antibiotics and catheter replacements. While receiving outpatient dialysis treatment on day 120 of the catheter, she developed a fever of 38°C and chills. There was no erythema, warmth, tenderness, or swelling at the exit site in the femoral area. A blood culture was obtained from the catheter which subsequently grew a Gram-negative rod identified as Delftia acidovorans by MicroScan WalkAway-40 BP combo panel type 34 (Siemens, Munich, Germany). The organism was susceptible to expanded-spectrum and broad-spectrum cephalosporins, aztreonam, carbapenems, piperacillin-tazobactam, ticarcillinclavulanate, and quinolones but resistant to all aminoglycosides, penicillin, and narrow-spectrum cephalosporins and intermediately susceptible to ampicillin-sulbactam. A 14-day course of cefepime was given through the catheter with hemodialysis when microbial identification and susceptibility results were available. The patient remained afebrile. Blood cultures drawn from the catheter before starting antibiotic therapy, 3 days and 7 days after the end of therapy, were negative. The catheter was not removed.Twenty-four days after cefepime was stopped, she became febrile again (38°C), with chills, after hemodialysis. Blood cultures were obtained from the catheter and peripheral vein. Vancomycin and cefepime were started, and she defervesced within 24 h. Staphylococcus epidermidis and D. acidovorans were identified from both specimens. The D. acidovorans isolate was initially not identifiable by MicroScan WalkAway (Siemens, Munich, Germany). Additional testing was done with Vitek and API 20 NE version 6.0 (bioMérieux, Marcy l'Etoile, France). The Vitek reported D. acidovorans with 53% probability, and the API 20 NE version 6.0 reported D. acidovorans as a significant taxon with an unacceptable profile. Finally, it was further characterized with long-chain-fatty-acid analysis by gas chromatography using the MIDI 62 system (Microbial Identification Systems, Newark, DE). The susceptibilities of the second D. acidovorans isolate by MicroScan were now reported as resistant to cefotaxime, cef...

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Section: Acidovorans Was Formerly Called Comamonas Acidovoransmentioning

confidence: 99%

Recurrent Intravascular-Catheter-Related Bacteremia Caused by Delftia acidovorans in a Hemodialysis Patient

et al. 2011

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“…It has occasionally been reported in cases of catheter-related bacteremia 2,3 , peritonitis in patients on continuous ambulatory peritoneal dialysis 4 , ocular infection 5 , endocarditis 6 , and infections in patients with AIDS 7 . It was also identified from some isolates referred to as "Burkholderia cepacia" from cystic fibrosis clinics and research 8 .…”

Section: Introductionmentioning

confidence: 99%

Delftia acidovorans Isolated from the Drainage in an Immunocompetent Patient with Empyema

et al. 2009

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Delftia acidovorans is a gram-negative motile rod found ubiquitously in soil and in water. Confirmed isolation from clinical infections is rare, and has been documented mostly in immunocompromised patients or those with indwelling catheters. A 53-year-old man was referred for the evaluation of a huge mass-like lesion found incidentally by chest X-ray. The lesion occupied more than half of the right lung and was diagnosed as a large loculated pleural effusion by CT scan. Bloody pus was drained through a percutaneous catheter, and D. acidovorans, identified by the Vitek GN card and confirmed by amplification of 16S ribosomal RNA and sequencing analysis, was isolated repeatedly from the drained pus. The patient was treated with imipenem/cilastatin to which the organism was sensitive. This is a rare report of chronic empyema associated with D. acidovorans in the respiratory system of an immunocompetent patient.

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“…However, most reported cases are due to Delftia acidovorans or to C. testosteroni. Both organisms are known to produce ocular infections (15,17,18), bacteremia, and central-line-associated bloodstream infections in patients with any underlying disease, such as malignancy, liver disease (11,13,14,16,(19)(20)(21)(22), and endocarditis (23, 24), among others. There is only one report of human infection due to C. terrigena in the literature.…”

Section: Pseudomonas Alcaligenesmentioning

confidence: 99%