Ocular immune reactants in patients dying with systemic lupus erythematosus

Histology and immunopathology of systemic lupus erythematosus affecting the conjunctiva

“…4 In a previous study on ocular tissue obtained at autopsy, Karpik et al 21 found thrombosis and moderate mononuclear perivascular infiltration in SLE conjunctiva. Our results suggest that ischaemia is not the critical factor for the acute epibulbar lesions, as thrombosis or hyaline degeneration was not found in any conjunctival tissue analysed.…”

“…25 Histopathological evidence of inflammation was more focal and less striking than the immunopatho logical evidence of immune reactant deposition, a finding which is supported by others. 21 The presence of immunodeposits in some patients with episcleritis, and their absence in others with recent episcleritis, may relate to response to therapy. 1626 However, immunodeposits have been found in clinically unin volved conjunctiva.…”

A clinical approach to the diagnosis of retinal vasculitis

“…The underlying pathological process is probably secondary to immune complex deposition in the vessel wall. These changes are found in all arterioles, including those of the retina and choroid [33]. Exacerbations of disease activity might manifest only in the retina as a retinal vascular occlusion [12] (Fig.…”

Recurrent Crescentic Membranous Nephropathy in Two Successive Renal Transplants: Association with Choroidal Effusions and Retinal Detachment

“…Experimentally induced serum sickness in rabbits is known to cause both uveitis and glomerulonephritis [5]. In patients with systemic lupus erythematosus, immunoglobulin deposits were detected in the walls of ocular blood vessels and were most prominent in ciliary processes and choroidal body [6]. Choroidal and retinal detachments have been noted in a patient with scleritis and Wegener's granulomatosis [7].…”