Ocular <i>Spiroplasma ixodetis</i> in Newborns, France

Matet, Alexandre; Flèche‐Matéos, Anne Le; Doz, François; Dureau, P.; Cassoux, Nathalie

doi:10.3201/eid2602.191097

Cited by 17 publications

(12 citation statements)

References 10 publications

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“…Little is known about the transmission between animal and human hosts. Nevertheless, spiroplasma ixodetis has been related to four cases of congenital cataract with anterior uveitis, suggesting intrauterine transmission [ 3 , 4 ]. Two patients each were affected either uni- or bilaterally.…”

Section: Discussionmentioning

confidence: 99%

Spiroplasma species as a rare cause of congenital cataract and uveitis: a case series

et al. 2021

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Background To date, only four cases of ocular spiroplasma infection have been reported in the entire ophthalmic literature. We add two more cases to raise awareness of this sight-threatening congenital disease that manifests as cataract with ocular inflammation. Case presentation Both infants were referred for cataracts associated with ocular inflammation. Case 1, a 3-week-old neonate presented with unilateral cataract, ocular inflammation and elevated intraocular pressure. Case 2 was a 3-month-old infant with bilateral cataract and panuveitis. Lensectomies with or without vitrectomy and subsequent analyses of the specimens were performed. Transmission electron microscopy and multiplex polymerase chain reaction or 16 s rRNA gene polymerase chain reaction revealed spiroplasma species. Conclusions Spiroplasma as a very rare cause for congenital cataract might be underdiagnosed. We recommend performing polymerase chain reaction to probe for spiroplasma species in congenital cataracts with an inflammatory component.

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Section: Discussionmentioning

confidence: 99%

Spiroplasma species as a rare cause of congenital cataract and uveitis: a case series

et al. 2021

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“…Therefore, it is crucial to understand what drives the density of nymphs infected with other tick microorganisms such as I. ricinus heritable symbionts, potentially opportunistic human and animal pathogens. For instance, both R. helvetica and S. ixodetis are suspected of persisting in vertebrate tissues (Binetruy et al, 2019;Hornok et al, 2014) and are associated with cases of human disease (Fournier et al, 2000;Matet et al, 2020;Aquilino et al, 2015). In Chapter 4, we showed that the association between the fluctuations in rodents and R helvetica NIP differed between years, and the association between the fluctuations in rodents and S. ixodetis NIP was negative.…”

Section: Assessment Of Disease Riskmentioning

confidence: 59%

“…Several studies described a long-lasting increase in the incidences of tick-borne diseases, most notably Lyme borreliosis and tick-borne encephalitis ( Jaenson et al, 2012;Mysterud et al, 2016). Furthermore, human infections and diseases involving Anaplasma phagocytophilum, Neoehrlichia mikurensis, spotted fever group Rickettsiae, and Spiroplasma ixodetis, are emerging (Matet et al, 2020;Parola, 2004;Parola & Raoult, 2001;Silaghi et al, 2016). Next to human pathogens, a variety of other bacterial microorganisms have evolved symbiotic relationships with I. ricinus (Carpi et al, 2011;Duron et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Questing microbioticks : Interactions of microbes, ticks, vertebrates, and the environment

Krawczyk

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The influence of external (a)biotic factors on the maintenance of symbionts in tick populations depends much on symbionts' mode of transmission. (this thesis) <. Ticks choose their symbionts rather than symbionts choose their ticks. (this thesis) =. An infection that is a burden for an individual can be beneficial for a population. @. The !AS rRNA amplicon sequencing technique is a powerful tool for forming hypotheses. H. We are selective about who or what should be a member of the (bio)diversity we want to preserve. A. Nowadays, it is difficult to distinguish what we really think from what we have read online.

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“…The role of hosts in the S. ixodetis transmission cycle is unknown [ 28 ]. Several European studies have described human cases of cataract and uveitis in newborn babies that showed evidence of transplacental infection with S. ixodetis [ 85 , 86 ].…”

Section: Discussionmentioning

confidence: 99%

Occurrence of tick-borne pathogens in questing Ixodes ricinus ticks from Wester Ross, Northwest Scotland

et al. 2021

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Background Lyme borreliosis and other tick-borne diseases emerge from increased interactions between humans, other animals, and infected ticks. The risk of acquiring a tick-borne infection varies across space and time, so knowledge of the occurrence and prevalence of pathogens in ticks can facilitate disease diagnosis in a specific area and the implementation of mitigation measures and awareness campaigns. Here we identify the occurrence and prevalence of several pathogens in Ixodes ricinus ticks in Wester Ross, Northwest Scotland, a region of high tourism and tick exposure, yet data-poor in terms of tick-borne pathogens. Methods Questing I. ricinus nymphs (n = 2828) were collected from 26 sites in 2018 and 2019 and tested for the presence of tick-borne pathogens using PCR-based methods. Prevalence was compared with other regions of Scotland, England, Wales, and the Netherlands. Results Anaplasma phagocytophilum (4.7% prevalence), Borrelia burgdorferi sensu lato (s.l.) (2.2%), Babesia from clade X (0.2%), Rickettsia helvetica (0.04%), and Spiroplasma ixodetis (0.4%) were detected, but no Neoehrlichia mikurensis, Borrelia miyamotoi, or Babesia microti. Typing of A. phagocytophilum using a fragment of the GroEL gene identified the presence of both ecotype I and ecotype II. Genospecies identification of Borrelia burgdorferi s.l. revealed B. afzelii (53% of infected nymphs), B. garinii (9%), B. burgdorferi sensu stricto (7%), and B. valaisiana (31%). We found similar prevalence of A. phagocytophilum in Wester Ross as in the Netherlands, but higher than in other parts of Great Britain. We found lower B. burgdorferi s.l. prevalence than in England or the Netherlands, and similar to some other Scottish studies. We found higher prevalence of B. valaisiana and lower prevalence of B. garinii than in other Scottish studies. We found S. ixodetis at much lower prevalence than in the Netherlands, and R. helvetica at much lower prevalence than in England and the Netherlands. Conclusions As far as we know, this is the first description of S. ixodetis in Great Britain. The results are relevant for disease surveillance and management for public and veterinary health. The findings can also aid in designing targeted public health campaigns and in raising awareness among outdoor recreationists and professionals. Graphical abstract

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Ocular Spiroplasma ixodetis in Newborns, France

Cited by 17 publications

References 10 publications

Spiroplasma species as a rare cause of congenital cataract and uveitis: a case series

Spiroplasma species as a rare cause of congenital cataract and uveitis: a case series

Questing microbioticks : Interactions of microbes, ticks, vertebrates, and the environment

Occurrence of tick-borne pathogens in questing Ixodes ricinus ticks from Wester Ross, Northwest Scotland

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