Ocular Hypertension Requiring Suspension of Inhaled Corticosteroids

Mogrovejo, Suliana; Moragón, Eva Martínez; Climent, María

doi:10.1016/j.arbr.2016.11.016

Cited by 2 publications

(1 citation statement)

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“…Almost all patients described returned to an IOP within normal range after discontinuation of the glucocorticoid alone; only one patient needed IOP-lowering eyedrops. In addition to these examples, multiple other case reports and case series on the subject have been published [ 48 , 49 , 50 , 51 ]. These reports suggest the need for clear clinical guidance regarding the ophthalmological follow-up of glucocorticoid users.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Intranasal, Inhaled and Systemic Glucocorticoids on Intraocular Pressure: A Literature Review

Wijnants

Stalmans

Vandewalle

2022

JCM

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Topical glucocorticoids are a well-known risk factor of intraocular pressure (IOP) elevation in one third of the general population and in up to 90% of glaucomatous patients. Whether this steroid response is caused by intranasal, inhaled or systemic glucocorticoids, is less known. This study presents an overview of the current literature on the topic, thereby providing guidance on when ophthalmological follow-up is indicated. A literature study was performed in Medline, and 31 studies were included for analysis. Twelve out of fourteen studies discussing intranasal glucocorticoids show no significant association with an elevated IOP. Regarding inhaled glucocorticoids, only three out of twelve studies show a significant association. The observed increase was either small or was only observed in patients treated with high inhaled doses or in patients with a family history of glaucoma. An elevated IOP caused by systemic glucocorticoids is reported by four out of the five included studies, with one study reporting a clear dose–response relationship. This review concludes that a steroid response can be triggered in patients treated with systemic glucocorticoids. Inhaled glucocorticoids may cause a significant IOP elevation when administered in high doses or in patients with a family history of glaucoma. At present, there is no evidence for a clinically significant steroid response caused by intranasally administered glucocorticoids.

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