“…While the pathophysiology of open-angle glaucoma, which may result in profound vision impairment if left untreated or if treated insufficiently, is not explicitly known, a number of risk factors, such as age, family history of glaucoma, diabetes mellitus, hypertension, myopia, cataracts, smoking, alcohol consumption, and stress, have been shown to be associated with open-angle glaucoma (Wilson et al, 1987;Katz and Sommer, 1988;Leske et al, 1995;Kaluza et al, 1996;Le et al, 2003;Suzuki et al, 2006). One of the most important risk factors for the development of open-angle glaucoma is elevated intraocular pressure (David et al, 1977;Seddon et al, 1983;Davanger et al, 1991;Sommer et al, 1991;Tielsch et al, 1991;Le et al, 2003;Suzuki et al, 2006), even though a considerable portion (30%) of patients with open-angle glaucoma have normal levels of intraocular pressure (Bonomi et al, 1998). Furthermore, in contrast to Western populations, the prevalence of open-angle glaucoma among patients with apparently normal intraocular pressure levels, i.e.…”