Investigation of laser treatment of intraocular tumors is of great interest for laser applications in ophthalmology and oncology. The main problem of laser treatment of tumors is to achieve complete coagulation of tumor body (volume) while the functioning of neighboring layers is preserved. The possible routes of laser irradiation (transpupillar, transscleral, endoscopic) of intraocular tumors are discussed. The investigation and selection of most appropriate wavelengths of laser radiation was made on the base of analysis of optical characteristics of pigmented and nonpigmented tumor tissues taking into account optical parameters of tumors, blood, melanin, water and results of computer modelling. It was established that radiation spectral interval between 1 and 1.3 µm (diode lasers with wavelengths between 1.0 -1.3 µm and Nd -Yag laser 1.064, 1.318 µm) is appropriate for these goals. Results of computer modelling of coagulation of tumor