Ocular graft-versus-host disease (oGVHD): From A to Z

Soleimani, Mohammad Ali; Sharif, Pouya Mahdavi; Cheraqpour, Kasra; Koganti, Raghuram; Masoumi, Ahmad; Baharnoori, Seyed Mahbod; Salabati, Mirataollah; Djalilian, Ali R.

doi:10.1016/j.survophthal.2023.02.006

Cited by 19 publications

(16 citation statements)

References 155 publications

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“…25 The inflammatory infiltrate with subsequent fibrosis explains the reduced tear production and the ocular surface keratinization in these patients. 5 Murine models have shown that fibroblasts express angiotensin II (AT II) and AT II type-1 receptor. AT II can mediate fibrotic pathways through the AT II type-1 receptor, which upregulates TGF-b and activates fibroblasts.…”

Section: Pathogenesis (Lacrimal Glands)mentioning

confidence: 99%

“…In aGVHD, conjunctival disease presents as hemorrhagic conjunctivitis, exudative conjunctivitis with pseudomembranes, chemosis, and corneal epithelial sloughing. 5 Mild chronic oGVHD is characterized by varying ranges of hyperemia, whereas severe disease can cause conjunctival scarring, punctal stenosis, and cicatricial entropion. 44…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…4 In contrast to other OSIDs, oGVHD has the particularity that it is a condition that provides the unique opportunity to know when will the disease start or "time zero": at the time of transplantation. 5 Knowing this could potentially enable a better understanding of the disease course, leading to early diagnosis, treatment, and improved outcomes in patients with oGVHD.…”

Section: Introductionmentioning

confidence: 99%

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Lessons Learned From Ocular Graft versus Host Disease: An Ocular Surface Inflammatory Disease of Known Time of Onset

Quiroga-Garza,

Ruiz-Lozano,

Rodriguez-Gutierrez

et al. 2024

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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The ocular surface inflammatory disorders (OSIDs) comprise a group of conditions characterized by persistent inflammation of the ocular surface and adnexal tissues. Systemic autoimmune diseases and hypersensitivity reactions cause them, and, if left untreated, can result in severe inflammatory dry eye, corneal damage, and vision loss. Ocular graft-versus-host disease (oGVHD) forms part of the ocular surface inflammatory disease umbrella. It is a condition occurring after allogeneic hematopoietic stem cell or bone marrow transplantation, usually in chronic graft-versus-host disease. oGVHD can virtually affect any ocular adnexal tissue, especially the meibomian glands, and cause persistent inflammation, tissue fibrosis, and subsequent chronic, severe dry eye disease. Among the OSIDs, oGVHD has the particularity that it has a “time zero,” meaning we know when the disease started. As such, preclinical models have leveraged this to investigate the molecular mechanisms involved in the damage oGVHD causes to the ocular surface. In oGVHD, establishing a “time zero” allows for predicting the clinical course and establishing adequate treatment. This is also possible because the inflammatory infiltration occurs in ocular surface tissues, which are readily accessible. Using oGVHD, we might be able to understand the immune response mechanisms in other OSIDs better (i.e., Sjögren syndrome, Stevens-Johnson syndrome, among others). This review presents an up-to-date overview of the pathogenesis, clinical presentation, and treatment of oGVHD. In addition, we will discuss the value of the “time zero” concept in the study of oGVHD.

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Section: Pathogenesis (Lacrimal Glands)mentioning

confidence: 99%

Section: Clinical Manifestationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lessons Learned From Ocular Graft versus Host Disease: An Ocular Surface Inflammatory Disease of Known Time of Onset

Quiroga-Garza,

Ruiz-Lozano,

Rodriguez-Gutierrez

et al. 2024

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…[ 47 ] Accordingly, the temperature of the wearer's eye may increase. [ 48 ] Thus, it is essential to make the choice of thin‐film components in smart contact lens operate within an appropriate temperature range after sufficient heat tests have been conducted: 1) limited thermal resistivity: when a smart contact lens is operating, electrical currents flow through the devices that are integrated with lens, resulting in Joule heating. Accordingly, the temperature of the wearer's eye may increase.…”

Section: Challenges With Smart Contact Lenses and Their Thin Filmsmentioning

confidence: 99%

A Review of Thin Films Used in Smart Contact Lenses

et al. 2023

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Smart contact lenses incorporate a diversity of thin‐film components and are also fabricated utilizing different thin films. They have been developed for the sensing and treatment of diseases such as intraocular pressure and glaucoma treatment using the tear fluid. This report provides a review of how these thin films are processed to develop functional characteristics relevant for their application in smart contact lenses. Types of thin films used, as well as various applications, are discussed from the historical developments leading to the invention of smart contact lenses to the state‐of‐the‐art technologies related to thin films used in them. Finally, challenges with contact lenses and improvements to tackle these challenges using thin films are presented.

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“…Moreover, oGVHD can affect almost all eye structures and causes no specific signs or symptoms [12] . Ocular structures such as the lacrimal glands, eyelids, conjunctiva, and cornea are the areas where structural or functional abnormalities often occur in oGVHD [7] , with dry eye being the most common form of oGVHD [13][14] . Typical symptoms of dry eye comprise foreign body sensation, photophobia, red eye, photophobia, tearing, ocular fatigue and other ocular discomfort.…”

Section: Introductionmentioning

confidence: 99%

Ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation

Fan¹,

Zeng²,

Huang³

et al. 2023

Int J Ophthalmol

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AIM: To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life (QOL) in patients after allogeneic hematopoietic stem cell transplantation (ALLO-HSCT). METHODS: Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020. They completed two questionnaires: the Ocular Surface Disease Index (OSDI) and the quality-of-life scale for Chinese patients with visual impairment (SQOL-DV1). Ocular conditions and systemic conditions were also assessed. RESULTS: Eye damage was correlated with total bilirubin (P=0.005), and gamma-glutamyl transferase (GGT) (P=0.021). There was no significant correlation between the overall QOL score and OSDI (P=0.8226) or SQOL-DV1 (P=0.9526) scores. The OSDI and the overall QOL score were not correlated with ocular conditions, including best-corrected visual acuity (BCVA), intraocular pressure, Schirmer tear test II, sodium fluorescein staining, tear film breakup time, and tear meniscus height. SQOL-DV1 was correlated with BCVA (P=0.0007), sodium fluorescein staining (P=0.007), and tear film breakup time (P=0.0146). CONCLUSION: In some patients, early ocular symptoms are not evident after ALLO-HSCT, while ocular surface complications can be observed after a comprehensive ophthalmological examination. Especially for those with elevated total bilirubin or GGT, regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease (oGVHD), especially for patients with elevated total bilirubin or GGT.

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Ocular graft-versus-host disease (oGVHD): From A to Z

Cited by 19 publications

References 155 publications

Lessons Learned From Ocular Graft versus Host Disease: An Ocular Surface Inflammatory Disease of Known Time of Onset

Lessons Learned From Ocular Graft versus Host Disease: An Ocular Surface Inflammatory Disease of Known Time of Onset

A Review of Thin Films Used in Smart Contact Lenses

Ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation

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