Ocular findings in thrombotic thrombocytopenic purpura (Moschcowitz's disease).

Percival, S.P.B.

doi:10.1136/bjo.54.2.73

Cited by 59 publications

(28 citation statements)

References 11 publications

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“…This is a rare ocular complication of TTP, which can develop, mostly late, in the course of the disease. [9][10][11] Retinal detachment is thought to occur due to localized ischaemic injury to the retinal pigment epithelium, caused by microthrombi in the small choroidal vessels, which inhibits adequate transport of fluid from the subretinal space. 11 Our patient regained complete vision by treatment with plasma exchange therapy.…”

Section: Resultsmentioning

confidence: 99%

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship

Riksen¹,

Luken²,

Klasen³

et al. 2007

Haematologica

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Please be advised that this information was generated on 2018-08-28 and may be subject to change. Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationshipWe present a patient with a history of benign monoclonal gammopathy, who developed thrombotic thrombocytopenic purpura (TTP), initially presenting as bilateral serous retinal detachment. Plasma of the patient contained high titers of anti-ADAMTS13 antibodies that were directed towards the disintegrin/TSR1/cysteine-rich/spacer and CUB1-2 domains. ADAMTS13 activity was undetectable. Total IgG purified from plasma of the patient partially inhibited ADAMTS13 activity. In contrast, the isolated M-protein did neither bind to, nor inhibit activity of ADAMTS13. We conclude that in this patient the monoclonal gammopathy and TTP co-existed as distinct pathological entities.

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Section: Resultsmentioning

confidence: 99%

Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship

Riksen¹,

Luken²,

Klasen³

et al. 2007

Haematologica

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“…Anisocoria, subconjunctival hemorrhage, scintillating scotoma and extra-ocular muscle paresis may be present. 12 Homonymous hemianopia and optic atrophy may also be seen if vessels supplying optic nerve are involved.…”

Section: Thrombotic Thrombocytopenic Purpura (Ttp)mentioning

confidence: 99%

Ophthalmic considerations in pregnancy

Chawla

Chaudhary

Aggarwal

et al. 2013

Medical Journal Armed Forces India

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Eye diseases in pregnancy Pregnancy complications Pregnancy physiology a b s t r a c tThe eyes are our window to the world and offer us an island of vision in the sea of darkness.Equally, the eyes are also a window to peep into what is going on in the milieu interior.Pregnancy is a natural state of physiological stress for the body. Each organ system of the body in a pregnant lady behaves at variation than in a non-pregnant state. A complex interplay exists between how the pregnancy affects the eye and how ocular physiology and pathology may lead to the modification of the management of pregnancy. Added to this is the effect of systemic conditions on the eye which gets modified by pregnancy.

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“…[1][2][3] Although this feature has been described before, previous cases were reported to occur after systemic signs of TTP were established. [4][5][6] Thrombotic thrombocytopenia purpura has an incidence of 3.7 per million, occurring most frequently in young female adults. In many cases remission is achieved and so the prevalence is increasing.…”

Section: Commentmentioning

confidence: 99%

“…TTP is caused by platelet thrombi principally in the renal and cerebral circulations and aggregations can also occur in the choroidal circulation with overlying serous fluid in the subretinal space. 4 The cause is thought to be from excessive platelet aggregation mediated by ultralarge von Willebrand Factor (ULVWF) multimers caused by a failure of the proteolytic action of metalloproteinases, such as ADAMTS 13, in affected patients. 7 Unexplained patchy serous retinal detachment should prompt investigation for TTP with a full blood count …”

Section: Commentmentioning

confidence: 99%