2011
DOI: 10.1167/iovs.10-7066
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Ocular Fibroblast Diversity: Implications for Inflammation and Ocular Wound Healing

Abstract: The results highlight the inherent differences between ocular fibroblast strains and provide crucial insight into novel, tissue-specific treatments for ocular inflammation and disease, such as RelB overexpression.

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Cited by 44 publications
(35 citation statements)
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“…Cell culture supernatants were collected at the conclusion of each experiment. IL-6, IL-8, and MCP-1 were detected in the supernatants by ELISA as previously described (48). IL-6 antibodies were purchased from BD Pharmingen (554543 and 554546, San Diego, CA).…”
Section: Methodsmentioning
confidence: 99%
“…Cell culture supernatants were collected at the conclusion of each experiment. IL-6, IL-8, and MCP-1 were detected in the supernatants by ELISA as previously described (48). IL-6 antibodies were purchased from BD Pharmingen (554543 and 554546, San Diego, CA).…”
Section: Methodsmentioning
confidence: 99%
“…-27 -populations of ocular fibroblasts and keratocytes Wilson et al, 2004;Xi et al, 2011). In other eye locations and during subsequent stages of cornea repair , intercellular crosstalk between myofibroblast precursors and inflammatory cells is likely as important as described for various organs (Borthwick et al, 2013;Brancato and Albina, 2011;Eming et al, 2007;Martin and Leibovich, 2005;Mosser and Edwards, 2008;Wynn et al, 2013;Wynn and Ramalingam, 2012).…”
Section: A C C E P T E D Accepted Manuscriptmentioning
confidence: 97%
“…Human Tenon fibroblasts undergo a cascade of cellular and biochemical events involving the activation, migration, and proliferation of these cells, together with the deposition of new extracellular matrix and scar formation. 18 This healing response may be more aggressive in children and young adults. 19 Surgical results of trabeculectomy in the pediatric age group are frequently disappointing.…”
Section: Discussionmentioning
confidence: 99%