“…The clinical features of FEVR vary widely, ranging from slight peripheral retinal vascular anomalies with no visual impairment to total blindness caused by severe retinal detachment. 2 – 6 As a genetic disease, FEVR can be inherited in an autosomal dominant, autosomal recessive, or X-linked pattern. Sixteen genes and 1 locus including FZD4, 7 NDP , 8 LRP5 , 9 TSPAN12 , 10 ZNF408 , 11 KIF11 , 12 RCBTB1 , 13 CTNNB1 , 14 ILK , 15 JAG1 , 16 ATOH7 , 17 CTNNA1 , 18 CTNND1 , 19 LRP6 , 20 DGL1 , 21 TGFBR2 , 22 and EVR3 23 had been identified to be associated with FEVR.…”