Ocular extramedullary myeloid leukaemia

Ohanian, Maro; Pemmaraju, Naveen; Rozovski, Uri; Alattar, Mona Lisa; Estrov, Zeev; Kundra, Vikas; Tung, Cynthia; Ravandi, Farhad; Manning, John T.; Abruzzo, Lynne V.

doi:10.1111/bjh.14430

Cited by 9 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 The common characteristics of orbital MS were proptosis, chemosis, orbital mass, and lid edema. 14 , 16 , 17 Ocular MS in adult AML patients was 10 out of 3,724 (0.3%) in the study, 17 whereas Cavdar et al reported 33 orbito-ocular MS in 133 Turkish children with AML. 18 The Children’s Oncology Group concluded that patients with MS involving orbital and central nervous system (CNS) sites had significantly better survival than patients with non-CNS MS, with CSF leukemia, or without extramedullary leukemia.…”

Section: Discussionmentioning

confidence: 65%

Acute Myeloid Leukemia Transformation from Myelofibrosis Upon Remission of an Orbital Myeloid Sarcoma – A Case Report

Chen

Lin

Hsu

et al. 2021

IMCRJ

View full text Add to dashboard Cite

Purpose To report a case of an orbital myeloid sarcoma concurrent with JAK2 mutation myelofibrosis, which rapidly transformed into acute myeloid leukemia upon aggressive treatment. Results A 51-year-old woman had progressive swelling of periorbita for one month. Magnetic resonance imaging demonstrated a well-defined, mild enhanced mass indenting the adjacent right lateral rectus muscle and the globe. Biopsy from anterior orbitotomy revealed an orbital myeloid sarcoma. Bone marrow study showed concurrent myelofibrosis. Although the orbital lesion subsided remarkably under aggressive chemotherapy and radiotherapy, the leukemic transformation was noticed in the third month following the initial presentation. Conclusion This case demonstrated that myeloid sarcoma should be included in the differential diagnosis of orbital diseases, with or without involvement of hematological disorders. Early diagnosis and aggressive treatment as for AML are crucial as the prognosis is usually poor for adult orbital MS.

show abstract

Section: Discussionmentioning

confidence: 65%

Acute Myeloid Leukemia Transformation from Myelofibrosis Upon Remission of an Orbital Myeloid Sarcoma – A Case Report

Chen

Lin

Hsu

et al. 2021

IMCRJ

View full text Add to dashboard Cite

show abstract

“…Myeloid sarcoma has many ophthalmic symptomatic manifestations [4-7]. Proptosis, lacrimal gland enlargement, orbital bone destruction, eyelid fullness, conjunctival masses, and anterior segment, choroidal and retinal infiltrates have all been observed.…”

Section: Discussionmentioning

confidence: 99%

“…A second smaller series of 10 cases originated from the M.D. Anderson Cancer Center [7]. There were 6 men and 4 women with a median age of 49 years (range 19–29 years); 6 had proptosis, 3 conjunctival lesions, and 1 retinal infiltrates.…”

Section: Discussionmentioning

confidence: 99%

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva

2018

View full text Add to dashboard Cite

An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Forty percent of the neoplastic cells were Ki-67 positive. Cytogenetic studies indicated a trisomy 8 (associated with worse prognosis) and a t(12; 17) translocation. Desmin, smooth muscle actin, pancytokeratin, CAM 5.2, adipophilin, tryptase, S100, SOX10, MART1, and E-cadherin were negative, ruling out a nonhematopoietic tumor. The conjunctival lesion was diagnosed as a myeloid sarcoma with megakaryoblastic differentiation, a rare variant. It probably arose from a myelodysplastic syndrome. This is the first case of its type to develop in the conjunctiva.

show abstract

“…At our institution, over a period of 12 years, 7% (252/3764) of adult AML patients demonstrated EML; 10 patients with EML (4%) had ocular involvement. Thus, at our institution, the overall incidence of ocular EML in adult AML patients is 10 out of 3,724 (0·3%) (Ohanian et al , ). Of the 10 cases of ocular AML that we reported, 4 were therapy‐related, and 2 de novo AML showed the t(8;21)(q22;q22) (Ohanian et al , ).…”

mentioning

confidence: 92%

“…Orbital extramedullary leukaemia is not a rare entity I read with great interest the paper by Ohanian et al (2018), in which they reported the rarity of orbital extramedullary myeloid leukaemia (EML) and discussed the management of their 10 cases. However, orbital EML is not a rare entityocular chloroma was presented in 1970 at the 13th International Congress of Haematology (Cavdar et al, 1971).…”

mentioning

confidence: 99%