Ocular Defects as Surrogate End-Points in Trials Comparing Carotid Endarterectomy and Stenting

Giannoukas, Athanasios D.; Paraskevas, Kosmas I.; Halliday, Alison

doi:10.1016/j.ejvs.2014.03.009

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 However, emboli generated during surgical treatment of ICA stenosis may also induce ischemic lesions of the ophthalmic artery, impacting on eye circulation and potentially leading to postoperative ocular defects. 13,14 So far, the effect of ICA stenosis and its surgical treatment on the choroidal structure has been poorly evaluated.…”

Section: Introductionmentioning

confidence: 99%

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Lareyre

Nguyen²,

Raffort

et al. 2017

Angiology

View full text Add to dashboard Cite

The influence of both severe chronic carotid stenosis and carotid endarterectomy (CEA) on ocular tissue has been poorly evaluated. The goal of this study was to measure subfoveal choroidal thickness (SFCT), before and after CEA, in patients with severe carotid stenosis. Consecutive patients (n = 36) with severe carotid stenosis were prospectively included. Patients (n = 19) were followed up at 1 and 3 months after CEA. The SFCT was measured bilaterally using enhanced depth imaging optical coherence tomography (EDI-OCT). Preoperatively, the median SFCT of the ipsilateral eye did not differ significantly from the contralateral eye (223 vs 236 µm; P = .75). In the ipsilateral eye, the mean SFCT was significantly higher at 1 month postsurgery and the effect was maintained at 3 months (226.3 ± 17.1 at 3 months vs 210.8 ± 16.5 µm at baseline; P < .001). For the contralateral eye, the increase in SFCT reached statistical significance at 3 months (220.1 ± 11.3 at 3 months vs 214.8 ± 11.5 µm at baseline; P = .04). The mean SFCT significantly increased bilaterally after CEA, with a more noticeable effect in the ipsilateral eye. Further studies are required to determine whether EDI-OCT could be useful as a potential marker of ophthalmologic outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Lareyre

Nguyen²,

Raffort

et al. 2017

Angiology

View full text Add to dashboard Cite

show abstract

“…[14] With the rapid development of proximal and distal embolus protection devices and advances in techniques, CAS has gained reliability in terms of complications and now has comparable results to conventional CEA. [15] There are studies indicating that CAS therapy or CEA increases cerebral and retinal blood flow, [16][17][18] as well as studies suggesting that the CAS method is effective in the treatment of ocular ischemic syndrome. [2,19,20] Despite improvements in techniques, intravascular procedures are a well-known accelerating factor for thromboembolic events.…”

Section: Discussionmentioning

confidence: 99%

Comparison of optical coherence tomography angiography results in patients with internal carotid artery stenosis who underwent carotid artery stenting and carotid endarterectomy

Ozdogru,

Kurumoglu Incekalan,

Simdivar

et al. 2024

Medicine

View full text Add to dashboard Cite

It is important to examine the ocular hemodynamic changes after carotid artery stenting (CAS) and carotid endarterectomy (CEA) in patients with internal carotid artery stenosis (ICAS). We aimed to compare the differences in retinal and optic nerve head blood flow after 2 surgical methods. The ipsilateral eyes of 34 patients who had over 50% ICAS with no ocular findings and 30 healthy controls were included in the study. Foveal avascular zone vessel density in the superficial retinal capillary plexus, deep retinal capillary plexus (DCP), and radial peripapillary capillary plexus (RPCP) were measured with an optical coherence tomography angiography device. These measurements were repeated 1 month after CAS or CEA in patients with ICAS. The preoperative and postoperative values of the patients were compared both within themselves and with the control group. When patients with ICAS were compared with the control group, lower vessel density values were found in the DCP parafovea, RPCP whole image, and peripapillary regions both before and after the procedure. There was no significant difference in terms of other parameters. Furthermore, there was no significant difference in any parameter examined between the pre- and postprocedural values of the patients who underwent CAS and CEA. DCP and RPCP are mostly affected in patients with ICAS. We observed that after application of the CAS and CEA methods, the effects on ocular blood flow were similar.

show abstract

Ocular Defects as Surrogate End-Points in Trials Comparing Carotid Endarterectomy and Stenting

Cited by 2 publications

References 16 publications

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Changes in Ocular Subfoveal Choroidal Thickness After Carotid Endarterectomy Using Enhanced Depth Imaging Optical Coherence Tomography: A Pilot Study

Comparison of optical coherence tomography angiography results in patients with internal carotid artery stenosis who underwent carotid artery stenting and carotid endarterectomy

Contact Info

Product

Resources

About