Ocular Copper Deposition Associated with Benign Monoclonal Gammopathy and Hypercupremia

Le, Probst; Hoffman, Eric D.; Mg, Cherian; Yang, Jun; Feagan, Brian G.; Adams, Paul C.; Nichols, Bruce D.

doi:10.1097/00003226-199601000-00017

Cited by 18 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical findings of an iridescent, multicolored, metallic sheen of copper deposition in Descemet's membrane of the cornea in our case are similar to those in two previously reported patients with hypercupremia (5)(6) . Copper is an essential trace element and constitutes an integral part of several enzyme systems.…”

Section: Discussionsupporting

confidence: 89%

“…Bilateral deposition of copper on Descemet's membrane occurs in a variety of conditions associated with hypercupremia, including multiple myeloma (1)(2)(3) , pulmonary carcinoma (4) , and also benign monoclonal gammanopathies (5)(6) . We describe the third case in the literature of deposition of copper in Descemet's membrane, which was found to be secondary to monoclonal gammopathy of undetermined significance (MGUS).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

Tzelikis¹,

Laibson²,

Ribeiro³

et al. 2005

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

Tzelikis¹,

Laibson²,

Ribeiro³

et al. 2005

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

“…M‐proteins may also bind to copper, transferrin, or serum phosphorus. A 10‐fold increase in the serum copper level owing to binding to a monoclonal IgG‐κ protein produced deposition of copper on Descemet's membrane and the lens capsule (234). M‐proteins with antibody activity and plasma cell dyscrasias have been reviewed (235).…”

Section: Association Of Monoclonal Gammopathy With Other Diseasesmentioning

confidence: 99%

Monoclonal gammopathies of undetermined significance: a review

Kyle

Rajkumar

2003

Immunological Reviews

109

View full text Add to dashboard Cite

Monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M-protein) in patients without evidence of multiple myeloma (MM), macroglobulinemia, amyloidosis (AL), or a related plasma cell proliferative disorder. MGUS is found in approximately 3% of persons older than 70 years and in about 1% of those older than 50 years. In a series of 1384 patients from south-eastern Minnesota in whom MGUS was diagnosed at Mayo Clinic from 1960 through 1994, the risk of progression was 1% per year. Patients were at risk of progression even after 25 years or more of a stable monoclonal gammopathy. The risk of development of MM was increased by 25-fold, the risk of macroglobulinemia was 46-fold, and the risk of primary AL was 8.4-fold when compared with a similar population (Surveillance, Epidemiology and End Results). The concentration of the serum M-protein was the major independent predictor of progression. Patients with an immunoglobulin M (IgM) or an IgA monoclonal gammopathy had a higher risk of progression than those with an IgG monoclonal gammopathy. The presence of a urine M-protein or the reduction of one or more uninvolved Igs was not a risk factor for progression. MGUS may be associated with many different disorders, including lymphoproliferative diseases, leukemia, connective tissue disorders, dermatologic diseases, and neurologic disorders.

show abstract

“…9,10 Similar cases of copper deposition in Descemet’s membrane and the anterior and posterior lens capsule from acquired systemic disorders with hypercupremia have also been reported. 11 …”

Section: Peripheral Corneal Ringsmentioning

confidence: 99%

Yellow Corneal Ring Associated with Vitamin Supplementation for Age-Related Macular Degeneration

Eller¹,

Gorovoy²,

Mayercik³

2012

Ophthalmology

View full text Add to dashboard Cite

Purpose To report the first described cases of peripheral yellow corneal rings secondary to vitamin supplementation for age-related macular degeneration (ARMD). Design Retrospective single-center case series. Participants The eyes of four patients taking vitamin supplementation for ARMD were examined at University of Pittsburgh Medical Center (UPMC) Department of Ophthalmology between January 2010 and April 2011. Methods We reviewed the medical records of four patients with peripheral corneal rings receiving vitamin supplementation for ARMD. Main Outcome Measures the presence of peripheral yellow corneal rings, skin findings, and serum carotene levels. Results Each patient had circumferential yellow peripheral corneal rings and exhibited subtle yellowing of the skin most notable on the palms. Serum carotene levels were normal in two of the three cases and markedly elevated in the last case in which it was measured. Conclusion It is unclear at this time how to counsel patients with this ocular finding. We suspect that these rings are more common than generally appreciated as they can have a subtle appearance or may be misdiagnosed as arcus senilis. We suggest that a formal study be performed on a cohort of patients taking macular degeneration vitamin supplementation that specifically screens for yellow rings and measures serum carotene levels when they are identified.

show abstract

Ocular Copper Deposition Associated with Benign Monoclonal Gammopathy and Hypercupremia

Cited by 18 publications

References 0 publications

Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

Monoclonal gammopathies of undetermined significance: a review

Yellow Corneal Ring Associated with Vitamin Supplementation for Age-Related Macular Degeneration

Contact Info

Product

Resources

About