Ocular Complications of Wegener's Granulomatosis

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

“…Currently, Eales' disease is in essence a diagnosis of exclusion of the diseases that are known to be associated with retinal vasculitis. [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] Epiretinal membranes obtained from the patients with Eales' disease could form a good specimen to study the aetiopathogenesis. 7 In its proliferative stages, Eales' disease mimics other vasoproliferative disorders like diabetic retinopathy and vascular occlusions.…”

“…Several immune-mediated diseases including Behcet's disease, sarcoidosis, rhematoid arthritis, Vogt-Koyanagi-Harada, Wegener's granulomatosis, and Crohn's disease causing retinal vasculitis are known to be associated with lymphocytic infiltration of the affected tissues. [32][33][34][35][36][37][38][39][40][41][42][43][44][45] Since we had excluded all the aforementioned conditions, lymphocytic infiltration in the ERMs was least expected. Our observation supports the hypothesis of triggering of immune mechanism by an unknown antigen in patients of Eales' disease resulting in active perivasculitis and resultant cascade of events observed at different stages of the disease process.…”

Limited Wegener's granulomatosis of the orbit: a case study and review of literature

“…However, as previous reports have included single-piece PMMA, 4,6 three-piece PMMA, 5 and acrylic 5 IOLs, no definite conclusion can be drawn. These factors are unlikely to be relevant in his right eye.…”

Wegener's granulomatosis causing lid destruction: a further sight-threatening complication

“…This is believed to result from focal vasculitis of the small vessels supplying the eye, and/or local granulomas and immune complex reaction and deposition. [1][2][3] Contiguous WG is thought to produce orbital/adnexal inflammation secondary to direct spread of the inflammatory process from the paranasal sinuses or nasopharynx. Pain, proptosis, motility restriction, eyelid oedema, forniceal ulceration (rarely), and recurrent nasolacrimal duct obstruction/ dacroadenitis occur.…”

“…1 The degenerative changes in pathological myopia initially involve the choriocapillaris, Bruch's membrane, and retinal pigment epithelium (RPE). 2 Central visual function may be affected by breaks in Bruch's membrane, choroidal neovascular membranes and associated haemorrhages, serous and/or haemorrhagic detachments of the retinal pigment epithelium.…”