Ocular Complications of Meningococcic Meningitis*

Lewis, Philip M.

doi:10.1016/s0002-9394(40)93270-6

Cited by 18 publications

(4 citation statements)

References 11 publications

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“…In 1923 Seguini [7] reviewed 342 cases of chorioretinitis and endogenous panophthalmitis caused by Streptococcus pneumoniae and b-hemolytic streptococci, and in 1940 Lewis [9] reported 23 cases of meningococcal panophthalmitis among 350 cases of meningococcal infections reported during 1893-1939. Other known ocular manifestations of severe, disseminated infections include orbital cellulitis [10,11], scleritis [12], optic neuritis [13], choroidal abscess and choroidal infarcts [14][15][16][17][18][19], arterial retinal obstruction due to septic emboli [20][21][22][23], preretinal hemorrhages [22,24], subretinal neovascularization [16,25], retinal detachment [26], retinal periphlebitis [27], and others [28][29][30].…”

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confidence: 99%

A Prospective Search for Ocular Lesions in Hospitalized Patients with Significant Bacteremia

Bouza

Cobo-Soriano

Rodríguez‐Créixems

et al. 2000

Clinical Infectious Diseases

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The purpose of this study was to determine the prevalence, risk factors, and prognostic value of ocular lesions in unselected patients with bacteremia. A total of 202 bacteremic patients, 101 nonbacteremic septic patients, and 90 nonseptic control patients were compared in a prospective, controlled, observational study. Ocular lesions related to bacteremia were found in 12% of the bacteremic group, 5% of the septic group, and 2% of the control group. Ocular lesions were significantly more frequent in the bacteremic patients than in the control patients (P=.007). The severity of the clinical condition and the presence of fungemia predict independently a higher risk of ocular lesions. Mortality rates among bacteremic patients with and without ocular lesions were, respectively, 32% and 8% (P<.01; OR, 3.99). The asymptomatic nature of most ocular lesions in patients with bloodstream infections and the impossibility of amelioration in most cases lead us to recommend ophthalmologic examination for bacteremic patients only when prognostic information is needed.

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confidence: 99%

A Prospective Search for Ocular Lesions in Hospitalized Patients with Significant Bacteremia

Bouza

Cobo-Soriano

Rodríguez‐Créixems

et al. 2000

Clinical Infectious Diseases

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“…However, it has now been reported in 10.7% of all published S. zooepidemicus meningitis cases. This may suggest it could occur more frequently in S. zooepidemicus meningitis than in meningitis caused by other microorganisms such as Streptococcus pneumoniae or Neisseria meningitidis [14,15]. Endogenous endophthalmitis is generally associated with poor visual outcome [16].…”

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confidence: 99%

Endogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report

et al. 2015

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BackgroundStreptococcus equi subspecies zooepidemicus (Streptococcus zooepidemicus) is a rare cause of meningitis in humans. Humans mainly get infected by contact with an animal source or by ingestion of unpasteurized dairy products. In rare cases, bacterial meningitis can be complicated by endogenous endophthalmitis which is frequently associated with a poor visual prognosis.Case presentationA 73 year old male Caucasian patient presented with clinical signs indicative of bacterial meningitis. Blood and cerebrospinal fluid cultures yielded beta-hemolytic, catalase-negative cocci. The strain was identified as Streptococcus zooepidemicus. The patient was likely infected by contact with a sick horse. Under antibiotic treatment, his general condition improved rapidly. Early after hospital admission, however, he began seeing a black spot in his left eye’s central visual field. An ophthalmological examination revealed signs of endogenous endophthalmitis and so the patient underwent vitrectomy. Despite treatment, the visual acuity of his left eye remained severely impaired. He showed no further neurological deficits at hospital discharge.ConclusionMeningitis caused by Streptococcus zooepidemicus is rare with only 27 previously published adult cases in the literature. Of note, this report constitutes the third description of endogenous endophthalmitis associated with Streptococcus zooepidemicus meningitis. Thus, endogenous endophthalmitis may represent a comparatively common complication of meningitis caused by this microorganism.

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“…The most serious complication is endophthalmitis that may lead to loss of vision 23 . In the pre-antibiotic era, meningococcus was the most common cause of endophthalmitis and it developed in 5% of patients 24 . In our series ocular changes were found in seven (2.8%) and they developed most frequently within the first three days after the onset of the disease, being more frequent among the patients with meningitis.…”

Section: Discussionmentioning

confidence: 99%