Ocular Complications of Human Immunodeficiency Virus Infection in Eastern China

Wang, Zhiliang; Jia, Renbing; Ge, Shengfang; He, Taiping; Zhang, Yunzhi; Yang, Yaling; Wang, Yefei; Shi, Wodong; Ji, Yongrong; Ye, Fuxiang; Lu, Jianfeng; Sun, Jing; Xu, Xinglian; Zhou, Yixiong; Gu, Ping; Luo, Min; Lu, Hongzhou

doi:10.1016/j.ajo.2011.07.018

Cited by 17 publications

(14 citation statements)

References 25 publications

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“…The prevalence of fundus lesions in our study population was lower than in populations included in previous investigations from Western countries before the HAART era, but it was higher than in previous reports from mainland China (Wang et al. 2012).…”

Section: Associations With the Prevalence Of Cytomegalovirus Retinitcontrasting

confidence: 88%

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Cytomegalovirus retinitis in pre‐HAART AIDS patients in China

Sun

You

Jonas

et al. 2013

Acta Ophthalmologica

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Section: Associations With the Prevalence Of Cytomegalovirus Retinitcontrasting

confidence: 88%

“…2012). Wang et al. (2012) reported recently that in 718 HIV/AIDS patients from Eastern China, CMVR was the most common ocular complications, with a prevalence of 10.6%.…”

Section: Associations With the Prevalence Of Cytomegalovirus Retinitmentioning

confidence: 99%

Cytomegalovirus retinitis in pre‐HAART AIDS patients in China

Sun

You

Jonas

et al. 2013

Acta Ophthalmologica

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“…Cytomegalovirus retinitis (CMVR) is the most common HIV ocular complication, and microvasculopathy, which is called HIV retinopathy in patients without ocular opportunistic infections, has the second-highest prevalence (9.4%) [1], which could result in a high incidence of blindness within the HIV-infected population [2], [3]. A detectable HIV-1 viral load has been found in tears, even in patients under long-term HAART who have an undetectable plasma viral load [4].…”

Section: Introductionmentioning

confidence: 99%

HIV-1 Tat-Mediated Apoptosis in Human Blood-Retinal Barrier-Associated Cells

Che

Deng

et al. 2014

PLoS ONE

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HIV-1-associated ocular complications, such as microvasculopathies, can lead to the loss of vision in HIV-1-infected patients. Even in patients under highly active antiretroviral therapy, ocular lesions are unavoidable. Ocular complications have been demonstrated to be closely related to the breakdown of the blood-retinal-barrier (BRB); however, the underlying mechanism is not clear. The data from this study indicated that the HIV-1 Tat protein induced the apoptosis of human retinal microvascular endothelial cells (HRMECs) and retinal pigmen epithelium (RPE) cells, which compose the inner BRB and the outer BRB, respectively. In addition, this study found that the activation of N-methyl-D-aspartate receptors (NMDARs) was involved in the apoptosis of RPE cells, but it caused no changes in HRMECs. Furthermore, both cell types exhibited enhanced expression of Bak, Bax and Cytochrome c. The inhibition of Tat activity protected against the apoptosis induced by NMDAR activation and prevented the dysregulation of Bak, Bax and Cytochrome c, revealing an important role for the mitochondrial pathway in HIV-1 Tat-induced apoptosis. Together, these findings suggest a possible mechanism and may identify a potential therapeutic strategy for HIV-1-associated ocular complications.

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“…For instance, cytomegalovirus, varicella-zoster virus and herpes simplex virus have been described as the most common causes for retinitis, iridocyclitis, keratitis, and other ocular diseases in HIV-1 patients (13,16,17). In a cross-sectional study of 787 cases of HAART-treated HIV-1 patients in eastern China, we have found the prevalence of ocular complications to be 26.3%; among them, cytomegalovirus retinitis had the highest prevalence (10.6%), followed by ocular microangiopathy (9.4%) (15). Other than HIV-1 and AIDS-associated opportunistic pathogens, Ebola virus had been detected in ocular tissues among survivors during convalescence (18).…”

mentioning

confidence: 98%

“…A proportion of HIV-1 patients have ocular complications (12)(13)(14)(15), mainly attributable to various ocular opportunistic infections. For instance, cytomegalovirus, varicella-zoster virus and herpes simplex virus have been described as the most common causes for retinitis, iridocyclitis, keratitis, and other ocular diseases in HIV-1 patients (13,16,17).…”

mentioning

confidence: 99%

HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability

Qian

Jiang

et al. 2016

Journal of Biological Chemistry

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Approximately 70% of HIV-1 infected patients acquire ocular opportunistic infections and manifest eye disorders during the course of their illness. The mechanisms by which pathogens invade the ocular site, however, are unclear. Under normal circumstances, vascular endothelium and retinal pigment epithelium (RPE), which possess a well developed tight junction complex, form the bloodretinal barrier (BRB) to prevent pathogen invasion. We hypothesize that disruption of the BRB allows pathogen entry into ocular sites. The hypothesis was tested using in vitro models. We discovered that human RPE cells could bind to either HIV-1 gp120 glycoproteins or HIV-1 viral particles. Furthermore, the binding was mediated by dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) expressed on RPE cells. Upon gp120 binding to DC-SIGN, cellular NF-B signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the BRB integrity. DC-SIGN knockdown or prior blocking with a specific antibody abolished gp120-induced matrix metalloproteinase expression and reduced the degradation of tight junction proteins. This study elucidates a novel mechanism by which HIV, type 1 invades ocular tissues and provides additional insights into the translocation or invasion process of ocular complication-associated pathogens.

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Ocular Complications of Human Immunodeficiency Virus Infection in Eastern China

Cited by 17 publications

References 25 publications

Cytomegalovirus retinitis in pre‐HAART AIDS patients in China

Cytomegalovirus retinitis in pre‐HAART AIDS patients in China

HIV-1 Tat-Mediated Apoptosis in Human Blood-Retinal Barrier-Associated Cells

HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability

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