Ocular colobomata in Charolais cattle

Multiple ocular developmental defects in four closely related alpacas

“…Certainly, posterior segment colobomata, such as in three of the four alpacas of the current report are believed to be inherited in some breeds of cattle and dogs . A 1972 report of colobomata in Charolais cattle described bilateral typical colobomata with respect to their position on the optic disk; their sizes ranged widely, and occasionally they affected the entire optic disk . Genetic studies suggested a dominant mode of inheritance with variable expressivity .…”

“…Due to concerns regarding a potential genetic cause for the ocular defects seen in Alpaca 1, the owners were advised against breeding this individual or repeating the breeding that produced Alpaca 1. Certainly, posterior segment colobomata, such as in three of the four alpacas of the current report are believed to be inherited in some breeds of cattle 6 and dogs. 12,13 A 1972 report of colobomata in Charolais cattle described bilateral typical colobomata with respect to their position on the optic disk; their sizes ranged widely, and occasionally they affected the entire optic disk.…”

“…12,13 A 1972 report of colobomata in Charolais cattle described bilateral typical colobomata with respect to their position on the optic disk; their sizes ranged widely, and occasionally they affected the entire optic disk. 6 Genetic studies suggested a dominant mode of inheritance with variable expressivity. 7 In dogs, ocular posterior segment colobomata can be seen alone or as a component of Collie eye anomaly (CEA).…”

“…Few congenital uveal and posterior segment defects have been described in living camelids, though histopathologic reports are more numerous . While thoroughly described in other species including cattle and dogs, colobomata as heritable defects have yet to be demonstrated in camelids . Therefore, the purpose of this study was to describe the initial clinical ophthalmic examination findings and subsequent gross pathologic and histopathologic findings of an alpaca with multiple ocular abnormalities and signs of visual impairment.…”

“…[1][2][3][4] While thoroughly described in other species including cattle and dogs, colobomata as heritable defects have yet to be demonstrated in camelids. [5][6][7] Therefore, the purpose of this study was to describe the initial clinical ophthalmic examination findings and subsequent gross pathologic and histopathologic findings of an alpaca with multiple ocular abnormalities and signs of visual impairment. Also described are the pedigree analysis and clinical ophthalmic examination findings of three alpacas closely related to the initial patient evaluated.…”