Ocular Co-Morbidities of Atopic Dermatitis. Part I: Associated Ocular Diseases

Beck, Kristen M.; Seitzman, Gerami D.; Yang, Eric J.; Sanchez, Isabelle M.; Liao, Wilson

doi:10.1007/s40257-019-00455-5

Cited by 41 publications

(57 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most patients reported having at least one ocular symptom within the past month at baseline, and a substantial proportion of symptoms were moderate to severe. The burden of ocular surface disorders in this patient population is consistent with other studies demonstrating a substantially greater incidence of ocular surface disorders among patients with type 2 inflammatory disorders, such as AD, asthma, and rhinosinusitis, compared with the general population [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Discussionsupporting

confidence: 87%

“…Previous studies have demonstrated an association of AD severity with increased risk of ocular disorders [1,6,13]. Although the burden of ocular disorders has been demonstrated to be high in patients with AD compared with the general population [1][2][3][4][5][6][7][8][9][10][11][12], there is also an association of AD with other type 2 inflammatory comorbidities such as allergies, asthma, and rhinitis, and in turn these type 2 inflammatory diseases are also associated with increased incidence of ocular disorders [15,16]. Therefore, it is difficult to identify the relative contributions of AD and other associated type 2 inflammatory disorders to comorbid ocular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with atopic dermatitis (AD) have a greater risk of conjunctivitis and other ocular surface disorders (e.g., atopic keratoconjunctivitis [AKC], keratoconus, herpetic eye disease, and dry eye) than the general population [1][2][3][4][5][6][7][8][9][10][11][12]. The prevalence rates of ocular surface disorders in patients with AD are high, with studies showing up to 32-42% of patients with AD reporting eye disease or prescriptions for eye disorders in the past 12 months [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence rates of ocular surface disorders in patients with AD are high, with studies showing up to 32-42% of patients with AD reporting eye disease or prescriptions for eye disorders in the past 12 months [1,5,6]. Some of these disorders, such as AKC, may lead to serious eye problems, impaired vision, or even vision loss [3,4,9]. Incidence of ocular surface disorders increases with AD severity and factors related to AD severity, including elevated circulating levels of IgE, thymus and activation-regulated chemokine, and eosinophils [1,6,13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Patient-Reported Ocular Disorders and Symptoms in Adults with Moderate-to-Severe Atopic Dermatitis: Screening and Baseline Survey Data from a Clinical Trial

Weyne

Blauvelt

Bruin‐Weller

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction: Patients with atopic dermatitis (AD) have a greater risk of conjunctivitis and other ocular surface disorders than the general population. We evaluated the burden of ocular surface disorders and related symptoms prior to treatment initiation in adults with moderate-tosevere AD. Methods: Patients were enrolled in a randomized, placebo-controlled, double-blinded, phase 3 trial of dupilumab administered with concomitant topical corticosteroids. At the beginning of the screening period, all enrolled patients completed a survey of ocular disorder diagnoses received in the past year; at baseline, patients completed a survey of frequency and severity of ocular symptoms (discomfort, itching, redness, and tearing) experienced in the past month. Results: A total of 712 of 740 patients enrolled in the trial provided responses to the survey. At screening, 286 of 740 patients (38.6%) reported having at least one ocular disorder in the past year. At baseline, 499 of 712 respondents (70.1%) reported having at least one symptom within the past month. Of these patients, 4.4%, 6.0%, 5.5%, and 4.4%, respectively, reported having discomfort, itching, redness, and tearing all of the time. Mild discomfort, itching, redness, and tearing were reported by 26.1%, 33.7%, 30.8%, and 31.6% of patients, respectively, while 7.3%, 7.7%, 6.2%, and 4.2%, reported severe discomfort, itching, redness, and tearing, respectively. Conclusions: These data demonstrate a high burden of ocular surface disorders and related symptoms in a population of adults with moderate-to-severe AD. Dermatologists should be aware of increased incidence of these disorders in AD and query their patients for signs and symptoms of eye disease. ClinicalTrials.gov Registration Number: NCT0 2260986.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Patient-Reported Ocular Disorders and Symptoms in Adults with Moderate-to-Severe Atopic Dermatitis: Screening and Baseline Survey Data from a Clinical Trial

Weyne

Blauvelt

Bruin‐Weller

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…Por outro lado, o TRFL mostrou correlação significativa e positiva com níveis aumentados de FLG em pacientes com DA, reforçando a ideia de que a expressão de FLG na superfície ocular tem uma função protetora. Outro achado interessante em nosso estudo, que apóia a mesma ideia, foi a correlação negativa e significativa da FLG com a graduação de coloração da fluoresceína na superfície ocular em pacientes com DA (ou seja, quanto maior a expressão de FLG, mais fraca a coloração).Dessa maneira, a desregulação das proteínas FLG e CLD1 encontrada na conjuntiva dos pacientes com DA parece ter relação com um processo secundário de resposta ao sofrimento da superfície ocular, com intuito de proteção, mas que resultaria na cicatrização e queratinização da conjuntiva, e podem, não necessariamente, estar relacionada com a fisiopatologia das alterações oculares da DA, como ocorre na pele.Outros estudos suportam essa teoria, sugerindo que não há relação entre mutações comuns da FLG, um dos maiores pilares envolvidos na etiopatogenese da DA, e a prevalência de AKC(86,91) e de outras manifestações oculares(99) nos pacientes com DA.Quanto aos achados clínicos, a acuidade visual foi pior no grupo com DA do que no grupo controle, corroborando com os resultados de estudos que mostram perda de visão em pacientes com DA devido a cicatrizes da córnea, catarata, ceratocone e outras comorbidades (42,49,98,(100)(101)(102)(103). A produção lacrimal, avaliada pelo teste de Schirmer I, foi menor no grupo DA do que no grupo controle, mas dentro da faixa normal.…”

unclassified

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica

Callou¹

View full text Add to dashboard Cite

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica São Paulo 2019 Tese apresentada à Faculdade de Medicina da Universidade de São Paulo para obtenção do título em doutor em Ciências Programa de Oftalmologia Orientador: Profa. Dra. Ruth Miyuki Santo Co-orientador: Profa. Dra. Monique Matsuda Dedicatória DedicatóriaAos meus pais José Lívio e Bida, pelo amor incondicional, pelo apoio incessante a minha carreira profissional, por serem meus maiores exemplos de dedicação e firmeza de caráter e a quem serei eternamente grata.Ao meu esposo Bruno, que esteve ao meu lado em todas as etapas da construção desta tese e representou minha fortaleza nas partes mais árduas; com quem pude dividir aprendizados e de quem sempre recebi carinho, compreensão e estímulo.Ao meu filho Bernardo, que faz brotar em mim diariamente um desejo cada vez maior de crescer como ser humano e como profissional.Aos meus irmãos Clarice, Eduardo e Romero, pela certeza de que juntos somos mais fortes, por serem pilares na minha vida.Aos meus tios José Luiz e Amélia e as minhas primas Natália, Alexandra e Rosa, que vibraram com cada conquista e que significaram um porto seguro na minha trajetória em São Paulo.Ao meu avô Antônio Lyrio Callou (in memorian), que me deixou o grande legado de ingressar na carreira acadêmica.

show abstract

Comorbidity burden in adult atopic dermatitis: A population‐based study

Thyssen,

Henrohn,

Neary

et al. 2023

JEADV Clinical Practice

View full text Add to dashboard Cite

BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease that has been shown to be associated with allergic comorbidities. However, studies examining comorbidities in patients with AD are incomplete, which may contribute to suboptimal care.ObjectivesThe objective was to compare the risk of developing different allergic and nonallergic comorbidities among adult patients with AD to that of a matched reference cohort in Sweden.MethodsThis was a nationwide population‐based cohort study using longitudinal data from primary and specialist care registers. AD patients were identified by confirmed diagnosis in primary or specialist care. A non‐AD reference cohort was randomly drawn from the general population and matched 1:1 with the AD patients on age, gender, and geographical region. The risk of developing the following conditions was evaluated: asthma, food hypersensitivity, allergic rhinitis, neurological disorders, psychiatric disorders, infections, immunological & inflammatory disorders, type 1 diabetes (T1D), type 2 diabetes (T2D), endocrine & metabolic disorders, skeletal disorders, ocular disorders, cardiovascular diseases, and malignancies.ResultsThis study included 107,774 AD patients [mild‐to‐moderate (n = 92,413) and severe (n = 15,361)] and an equally‐sized reference cohort. AD patients displayed a higher risk of developing comorbid conditions for all investigated categories, except for T1D, compared with the reference cohort. The highest risk compared with the reference cohort was observed for allergic comorbidities followed by immunological & inflammatory disorders (hazard ratio: 2.15) and infections (hazard ratio: 2.01). Patients with AD also had higher risk of developing multiple comorbidities (2 or more). The risk of comorbidity onset increased alongside AD severity and patients with active AD were associated with increased risk of comorbidity onset compared with patients in remission.ConclusionsAD patients are at an increased risk of developing many comorbidities that extend beyond allergic conditions. This study highlights the need for interdisciplinary follow‐up of comorbidities in the management of AD patients to reduce overall patient burden.

show abstract

Ocular Co-Morbidities of Atopic Dermatitis. Part I: Associated Ocular Diseases

Cited by 41 publications

References 71 publications

Patient-Reported Ocular Disorders and Symptoms in Adults with Moderate-to-Severe Atopic Dermatitis: Screening and Baseline Survey Data from a Clinical Trial

Patient-Reported Ocular Disorders and Symptoms in Adults with Moderate-to-Severe Atopic Dermatitis: Screening and Baseline Survey Data from a Clinical Trial

Análise da expressão das proteínas de barreira epitelial, filagrina e claudina-1, na superfície ocular de pacientes portadores de dermatite atópica

Comorbidity burden in adult atopic dermatitis: A population‐based study

Contact Info

Product

Resources

About