Ocular Biometry in the Subtypes of Angle Closure: An Anterior Segment Optical Coherence Tomography Study

Moghimi, Sasan; Vahedian, Zakieh; Fakhraie, Ghasem; Ghaffari, Reza; Eslami, Yadollah; Jabarvand, M; Zarei, Reza; Mohammadi, Massood; Lin, Shan

doi:10.1016/j.ajo.2012.10.014

Cited by 100 publications

(61 citation statements)

References 33 publications

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“…8,9 As I-curve is reported to be only moderately correlated with increased LV, pupillary block may not be the only mechanism by which increased LV causes angle closure. 9,10 In fact, there are some cases with exaggerated LV in which the iris appears to drape the anterior surface of the lens, giving rise to a 'volcano-like configuration' without an increase in I-curve. 2,11 Exaggerated LV has been defined quantitatively as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs.…”

Section: Introductionmentioning

confidence: 99%

Role of lens vault in subtypes of angle closure in Iranian subjects

Moghimi

Vahedian

Zandvakil

et al. 2014

Eye

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Purpose The purpose of this study is to quantify anterior chamber (AC) parameters and to determine the proportion of eyes with exaggerated lens vault (LV) in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT). Patients and methods In this prospective study, 115 eyes of 115 Iranian patients with angle closure disease were included and categorized into three groups: (1) fellow eyes of acute angle closure (AAC; 40 eyes); (2) primary angle closure glaucoma (PACG; 39 eyes); and (3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Angle parameters, LV, and iris thickness (IT) were measured using AS-OCT. An exaggerated LV was defined as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs. Results Fellow eyes of AAC had the shallower AC (P ¼ 0.01), greater iris curvature (I-curve; P ¼ 0.01), and higher LV (P ¼ 0.02) as compared with PACS and PACG eyes. There was no statistically significant difference in the mean IT at 750 mm from scleral spur among the three groups (P ¼ 0.45). Exaggerated LV was found in 67.5, 35.9, and 40% of fellow eyes of AAC, PACG, and PACS, respectively, (P ¼ 0.008) with an odds ratio of 1.92 (P ¼ 0.005) for fellow vs PACG and 1.68 (P ¼ 0.01) for fellow vs PACS. Conclusions Exaggerated LV is highly prevalent in fellow eyes of AAC. These eyes have shallower AC depth, greater I-curve, and higher LV when compared with PACG and PACS.

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Section: Introductionmentioning

confidence: 99%

Role of lens vault in subtypes of angle closure in Iranian subjects

Moghimi

Vahedian

Zandvakil

et al. 2014

Eye

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“…Moreover, recent studies have shown that LV has an important role in predisposing eyes to APAC. 7,8,10,26 Compared with normal controls, we found increased LV in both phacomorphic angle closure and APAC eyes. However, phacomorphic angle closure eyes have a mean LV that was 360 lm greater than in APAC eyes.…”

Section: Discussionmentioning

confidence: 63%

“…26,29 In fact, this type of non-pupil block angle closure mechanism, called ''exaggerated lens vault mechanism'' has been predominant in half of the APAC eyes in a study by Moghimi et al 15 In the literature, ACD has been reported as a risk factor in the development of angle closure disease. 7,8,30,31 In our previous report, APAC eyes had shallower ACD than their fellow eyes and primary angle closure and PACS eyes. 8 The importance of a shallow ACD in the predisposition toward an APAC attack has also been emphasized by other investigators.…”

Section: Discussionmentioning

confidence: 99%

“…A lens-induced mechanism has been suggested in the development of both APAC [7][8][9][10]26 and phacomorphic angle closure. 4,6,13,27 In a cross-sectional study by Nongpiur et al, 9 LV was found to be one of the strongest predictors of PACG.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 A shallow anterior chamber, thick peripheral iris, and anteriorly inserted iris are factors that make the eye more prone to an acute attack of angle closure. [7][8][9][10][11][12] Although the literature has shown an unusual greater thickness and/or anterior displacement of the crystalline lens may play a role in the development of angle closure disease, lens factors may have even more crucial roles in APAC. That might be a reason that lens extraction has been considered a treatment of choice for phacomorphic angle closure eyes and peripheral iridotomy for APAC eyes.…”

mentioning

confidence: 99%

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