Abstract:A total of 44 eyes of 22 ferrets were examined by B-mode ultrasonography. Four dimensions were measured: the distance from the corneal surface to the anterior lens surface (M1), the axial lens thickness (M2), the distance from the posterior lens surface to the retina (M3) and the distance from the anterior cornea to the retina (M4). The values obtained were (mean, standard deviation, range): M1: 1.31 +/- 0.16 mm (1-1.7); M2: 3.42 +/- 0.15 mm (3.2-3.7); M3: 2.26 +/- 0.11 mm (2.1-2.5); M4: 7 +/- 0.24 mm (6.4-7.7… Show more
“…The identification of intraocular structures and their corresponding peaks using A and B‐modes was possible in all animals, as previously reported 9,10,21 20 and ferrets, 4 but differs for dogs as they have different cranial conformations 22,23…”
Section: Discussionsupporting
confidence: 56%
“…Ultrasound scan is an essential tool in ophthalmology because it is a safe and noninvasive procedure which enables the evaluation of intraocular and retrobulbar structures without need of sedating or anesthetizing the patient 1–6 . Ophthalmic ultrasound is an auxiliary diagnostic tool and is especially indicated when there is opacification of the transparent media (cornea, aqueous humor, lens, and vitreous humor) 2,4,5,7 . It is also indicated for determination of variations in size, form, or position of the eye 8,9 …”
“…The identification of intraocular structures and their corresponding peaks using A and B‐modes was possible in all animals, as previously reported 9,10,21 20 and ferrets, 4 but differs for dogs as they have different cranial conformations 22,23…”
Section: Discussionsupporting
confidence: 56%
“…Ultrasound scan is an essential tool in ophthalmology because it is a safe and noninvasive procedure which enables the evaluation of intraocular and retrobulbar structures without need of sedating or anesthetizing the patient 1–6 . Ophthalmic ultrasound is an auxiliary diagnostic tool and is especially indicated when there is opacification of the transparent media (cornea, aqueous humor, lens, and vitreous humor) 2,4,5,7 . It is also indicated for determination of variations in size, form, or position of the eye 8,9 …”
“…In wild animals, B-scan biometric assessments were carried out on koalas (Hirst et al 1992), alligators (Maia et al 2003), ferrets (Hernandez-Guerra et al 2007), elephants (Nunnery et al 2008) and parrots (Lehmkuhl et al 2010).…”
B-scan ultrasonography is an important diagnostic tool that allows characterization of internal organ anatomy and, when complemented by Doppler ultrasound, allows vascular hemodynamic assessment, increasing the diagnostic accuracy. Thus, the aim of the present study was the B-scan ultrasound characterization and measurement of the eyeball segments and assessment of the external ophthalmic artery by color and pulsed Doppler. Sixty eyeballs were assessed from 30 dogs of different breeds using an 8.5MHz microconvex transductor. First, biometry was performed by B-scan of the following segments: axial length (M1), anterior chamber depth (M2), lens thickness (M3), lens length (M4), vitreous chamber depth (M5), optical disc length (M6) and optic nerve diameter (M7). Colored Doppler identified the external ophthalmic article and pulsed Doppler assessed its flow, and the following were measured: systolic peak velocity (VPS), final diastolic velocity (VDF), resistivity index (IR) and pulse index (IP). No statistical difference was observed for the biometric values of the eye segments between the right and left eyes (p>0.05). The vitreous chamber depth (M5) was shown to be the biometric variable with greatest bilateral symmetry, varying from 0.79 to 0.87cm and 0.78 to 0.86cm for the right and left eye, respectively. The ophthalmic artery was visualized over the optic nerve towards the eyeball, with flow stained red. There was no significant statistical difference between the Doppler velocimetric values for the ophthalmic artery between the right and left eye of the animals assessed (p>0.05). The mean resistivity index (RI) showed average values equal to 0.63±0.03, bilaterally. The mean base velocity was 17.50cm/s and 18.18cm/s at the systolic peak and 6.21cm/s and 6.68cm/s at the end of the diastole, for the right and left eyes respectively. The anatomic, biometric and hemodynamic characterization using the ultrasound B-scan and the Doppler modalities permitted the ultrasonographic and Doppler velocimetric assessment of the eyeball components in dogs of different breeds, and it can be used in ophthalmic clinical routine to identify eye pathologies.
“…The rabbit has long been used for the assessment of eye irritation and has since been utilized to study ocular disease following respiratory virus infection (65,73,81). The ferret has been recognized as an appropriate experimental model for studies involving the visual system and has been employed to study ocular inoculation of respiratory viruses (26,72,(82)(83)(84). As described below, these and other species have provided a greater understanding of how respiratory viruses cause ocular disease.…”
Section: Ocular Models Of Respiratory Virus Infectionmentioning
SUMMARY
Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing
in vitro
and
in vivo
models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism.
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