Ocular Bioavailability of Ciprofloxacin in Sustained Release Formulations

Ke, Tai-Lee; Cagle, Gerald D.; Schlech, Barry A.; Lorenzetti, O. J.; Mattern, Janet

doi:10.1089/10807680152729248

Cited by 25 publications

(11 citation statements)

References 10 publications

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“…These results correlates with permeability coefficients published in earlier studies. The permeability coefficient of ciprofloxacin in rabbit sclera was measured to be 1.88 ± 0.617 × 10 -5 cm/sec (74). Results for glucose diffusion are in good agreement with that for human sclera (75).…”

Section: Resultssupporting

confidence: 70%

Depth-resolved monitoring of analytes diffusion in ocular tissues

2007

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Optical coherence tomography (OCT) is a noninvasive imaging technique with high in-depth resolution. We employed OCT technique for monitoring and quantification of analyte and drug diffusion in cornea and sclera of rabbit eyes in vitro. Different analytes and drugs such as metronidazole, dexamethasone, ciprofloxacin, mannitol, and glucose solution were studied and whose permeability coefficients were calculated. Drug diffusion monitoring was performed as a function of time and as a function of depth. Obtained results suggest that OCT technique might be used for analyte diffusion studies in connective and epithelial tissues.

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Section: Resultssupporting

confidence: 70%

Depth-resolved monitoring of analytes diffusion in ocular tissues

2007

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“…This is attributed to the structural complexity of corneal layers. Inclusion of penetration enhancers (e.g., benzalkonium chloride, ethylenediaminetetraacetic acid, Tween 20, Brij ® 35, and dodecylmaltoside [29,30]), Cyclodextrins [31], and dendrimers [32,33] in ocular formulations has been reported to increase corneal penetration of the tested antibacterial agents [34].…”

Section: General Considerations For Designing Ocular Drug Delivery Fomentioning

confidence: 99%

Topical Drug Delivery for Effective Treatment of Bacterial Infections of the Anterior Segment of the Eye

El-Bary

Ibrahim

Haza'a

2018

Asian J Pharm Clin Res

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Anterior parts of the eye are susceptible to infections caused by different bacterial species. The use of suitable therapeutic measures in case of ocular infections can be sight saving. The appropriate therapy depends on selecting the right antibacterial as well as an efficient drug delivery system. Despite their accessibility, topical delivery of the selected antibiotic into the anterior ocular parts is still a challenging issue due to the complex nature of the eye. Ocular therapy would be significantly improved by modifying the physicochemical properties of the drug and by prolonging its pre-corneal residence time. This review will help pharmaceutical formulators to identify different parts of the eye and the corresponding bacterial infections, ocular barriers to drug delivery, and general consideration when formulating ocular drug delivery systems for the treatment of eye infections.

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“…The system was based on the use of carbopol gel or hydroxypropyl methyl cellulose as a viscosity enhancing agent in addition to dodecylmaltoside as a penetration enhancer to achieve the desired ocular absorption of ciprofloxacin. The carried out in vivo bioavailability studies showed that the sustained release formulations delivered 10-fold more drug into the aqueous humor than the standard solution formulation [19].…”

Section: Fig 6: Relationship Between the Amount Of Sd2 As A Matrix (mentioning

confidence: 99%

In Vivo Study of Promising Formulated Ocular Bio-Adhesive Inserts of Ciprofloxacin Hydrochloride Combination With Xanthan Gum and Carbopol

Alshawwa

Obaidat

Sallam³

et al. 2016

Int J Pharm Pharm Sci

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Objective: To study the in vivo behaviour and irritant properties of different ocular bio-adhesive inserts of ciprofloxacin hydrochloride (CFX-HCl) prepared using a spray dried (SD2) matrix system consisting of xanthan gum, carbopol, and propylene glycol.Methods: CFX-HCl in aqueous humor samples was analysed using HPLC method. Applying a mobile phase of 0.01M sodium acetate: methanol (70:30 v/v) with pH around 3.00, and using Purosphere star 100RP-18 column (125 mm × 4.6 mm × 5 µm). The in vivo behaviour and irritant properties of ocular inserts was studied on rabbits. Twelve rabbits were used for the study and were divided into four groups. After placing the insert in the eye 100 µl of the aqueous humor was withdrawn at different time intervals in order to measure the concentration profile of CFX-HCl. The tested formulae R, F1, F2, and F3 were all containing 6.25 mg of CFX-HCl. Results:The method was well validated according to linearity, recovery, and precision. Where the calibration curve was linear over a concentration range of (2.500-7.826) µg/ml, with an average recovery of 99.76%. The presence of the matrix system enhances the absorption of CFX-HCl and sustains its release up to four days leading to increasing its bioavailability. Also, the ocular inserts of F2 and F3 have better biocompatibility compared with R and F1. Conclusion:The analysis method was found sensitive, accurate and precise and could be used to assess the in vivo behaviour of CFX-HCl. The ratio of the free drug to the matrix system controlled the rate of drug release.

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Ocular Bioavailability of Ciprofloxacin in Sustained Release Formulations

Cited by 25 publications

References 10 publications

Depth-resolved monitoring of analytes diffusion in ocular tissues

Depth-resolved monitoring of analytes diffusion in ocular tissues

Topical Drug Delivery for Effective Treatment of Bacterial Infections of the Anterior Segment of the Eye

In Vivo Study of Promising Formulated Ocular Bio-Adhesive Inserts of Ciprofloxacin Hydrochloride Combination With Xanthan Gum and Carbopol

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