Ocular bacteriology

The Effectiveness of Lysostaphin Therapy for Experimental Coagulase-NegativeStaphylococcusEndophthalmitis

“…4,5 Cultures of normal tear films reveal that S. epidermidis is present more frequently and in greater numbers than any other organism. 1,6,7 A variety of the coagulase-negative species of Staphylococcus have been isolated from worn contact lenses. 6,8 In addition to being a major cause of conjunctivitis and endophthalmitis, 9−13 S. epidermidis causes 23-28% of the cases of keratitis, almost equivalent to that of S. aureus and Pseudomonas aeruginosa.…”

An Ocular Strain ofPseudomonas aeruginosais Inflammatory but not Virulent in the Scarified Mouse Model

“…There has been considerable research investigating the pathogenesis of P. aeruginosa in ocular infections. The strain focused on in this study differs from other pathogenic strains as it caused inflammation in the human eye, CLARE, which is characterised as a noninfectious inflammatory condition (Willcox and Stapleton, 1996 ;Holden et al, 1996). This study investigated the pathogenesis of this CLARE strain in the scarified mouse model in comparison to a wellcharacterised strain, ATCC 19660.…”

Chemotactic Activity of Tears and Bacteria Isolated During Adverse Responses

“…While the eye has a normal bacterial microbiota (Cagle and Abshire, 1981 ;Willcox and Stapleton, 1996), insertion of a contact lens into this environment can cause the introduction and establishment of bacteria other than the normal microbiota (Stapleton et al, 1995b). Many adverse responses seen with contact lens wear are associated with the presence of high bacterial numbers (Stapleton et al, 1995a ;Holden et al, 1996).…”