Ocular axial length measurement among normal adults using magnetic resonance imaging

Aiyekomogbon, Joshua Oluwafemi; Rafindadi, Abdulkadir L

doi:10.4103/0189-9171.207373

Cited by 5 publications

(4 citation statements)

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“…A prior study [ 20 ] of 340 normal eyes from a Nigerian population that used T 1 -weighted brain MRI to measure axial length found right and left globes to be 23.32 ± 1.34 mm (range 22.0 to 24.7) and 23.29 ± 1.22 mm (range 22.10 to 24.51) respectively, results similar to ours, but did not assess agreement to a reference standard. In an approach similar to that presented here, Mendez-Gomez et al [ 12 ] used two operators to measure axial length from brain scans in 104 elderly (mean age 80.8 years) people without dementia.…”

Section: Discussionsupporting

confidence: 68%

“…Here, we used one of the most commonly acquired brain MRI sequences, a whole brain T 2 -weighted scan which takes around 50 s to acquire on modern 3 T scanners, depending on acquisition parameters. Other sequences can be used for the purpose of measuring eye axial length, for instance Aiyekomogbon et al [ 20 ] and Mendez-Gomez et al [ 12 ] both used T 1 -weighted brain scans.…”

Section: Discussionmentioning

confidence: 99%

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Measuring axial length of the eye from magnetic resonance brain imaging

et al. 2022

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Background Metrics derived from the human eye are increasingly used as biomarkers and endpoints in studies of cardiovascular, cerebrovascular and neurological disease. In this context, it is important to account for potential confounding that can arise from differences in ocular dimensions between individuals, for example, differences in globe size. Methods We measured axial length, a geometric parameter describing eye size from T2-weighted brain MRI scans using three different image analysis software packages (Mango, ITK and Carestream) and compared results to biometry measurements from a specialized ophthalmic instrument (IOLMaster 500) as the reference standard. Results Ninety-three healthy research participants of mean age 51.0 ± SD 5.4 years were analyzed. The level of agreement between the MRI-derived measurements and the reference standard was described by mean differences as follows, Mango − 0.8 mm; ITK − 0.5 mm; and Carestream − 0.1 mm (upper/lower 95% limits of agreement across the three tools ranged from 0.9 mm to − 2.6 mm). Inter-rater reproducibility was between − 0.03 mm and 0.45 mm (ICC 0.65 to 0.93). Intra-rater repeatability was between 0.0 mm and − 0.2 mm (ICC 0.90 to 0.95). Conclusions We demonstrate that axial measurements of the eye derived from brain MRI are within 3.5% of the reference standard globe length of 24.1 mm. However, the limits of agreement could be considered clinically significant. Axial length of the eye obtained from MRI is not a replacement for the precision of biometry, but in the absence of biometry it could provide sufficient accuracy to act as a proxy. We recommend measuring eye axial length from MRI in studies that do not have biometry but use retinal imaging to study neurodegenerative changes so as to control for differing eye size across individuals.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Measuring axial length of the eye from magnetic resonance brain imaging

et al. 2022

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“…This study correlated length of the interzygomatic line(IZL) with some of the measurements of ocular structures and found majority of the variables showed statistically significant relationship with IZL.The facial size, which is represented by the length of the IZL, showed significant correlation with axial length of globe. 9 This observation is consonant with the larger head size in male as compared to female and there by difference in the size of the globe in males and females Axial length (AP) is one of the important indicators of refractive state of the eyes. Eye with axial length < 22mm are classed as hyperopic and those > 26mm as myopic.…”

Section: Discussionmentioning

confidence: 89%

“…In another study conducted by Innesa Bekerman et al 8 on 250 adult patients (500 eyeballs) also showed no significant difference in size of eyeball in relation to gender and age groups. In a study conducted by Joshua O Aiyekomogbon et al, 9 on a total of 340 globes of 170 patients in nigerian population on axial length of the eyeball showed significant difference in right and left globes.This study also showed higher values among male population.The mean axial length(AP) in our study population is 22.4 ± 0.9 mm which is less than the value obtained in the above study conducted by Joshua O Aiyekomogbon et al which is 23.31 ± 1.28 mm.This shows there are variations among different ethnic groups. This study correlated length of the interzygomatic line(IZL) with some of the measurements of ocular structures and found majority of the variables showed statistically significant relationship with IZL.The facial size, which is represented by the length of the IZL, showed significant correlation with axial length of globe.…”

Section: Discussionmentioning

confidence: 93%

Assessment of Normal Occular Volume Using Magnetic Resonance Imaging

Surekha¹,

Naveen²,

Rajendra³

et al. 2020

IJCMSR

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At the level of lens the transverse and AP diameters of right and left eyeballs were measured and the data obtained from the both eye were compared in relation to size, gender and age Results: The mean (mean ± 2 SD) ocular volume for right eye 5967.17 mm3 ± 1064.58 mm3 and for the left eye was 6025.4 mm3 ± 1455.81 mm3. The mean ocular volumes were different for either eyeball and sex (in males the right eye was 6057.79 mm3, left eye was 5980.02 mm3; while in females the right eye was 5829.74 mm3, left eye was 6141.4 mm3). Mean transverse diameter of the eyeball is 22.8 ± 1.1 mm. Mean antero posterior diameter of the eyeball is 22.4 ± 0.9 mm. Conclusion:The human adult eye approximately measures 22.8 ± 1.1 mm (transverse) and 22.4 ± 0.9 mm (axial) with no significant difference between sexes and age groups. These data can be helpful in ophthalmological, oculoplastic, and neurological practice. We noted that males had slightly bigger eyeballs size in comparison to females.

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