Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) – Report 2: Pattern of Uveitis Investigations in Singapore

Low, Rebecca; Chen, Elizabeth J; Ismail, Muhammad Amir Bin; Mi, Helen; Ling, Ho Su; Lim, Wei‐Wen; Teoh, Stephen C.; Agrawal, Rupesh

doi:10.1080/09273948.2018.1535080

Cited by 3 publications

(1 citation statement)

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“…U veitis and scleritis are important leading causes of ocular morbidity globally [1][2] , which attributes to 5%-10% of visual impairment worldwide [1,[3][4][5] . Ocular inflammation is responsible for 25% of blindness in developing countries and 5%-20% of blindness in developed countries [1,[6][7][8][9] . The incidence of uveitis was estimated between 17 to 52 cases per 100 000 persons per year while the prevalence was about 38 to 714 cases per 100 000 persons per year [1,[10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Treatment of uveitis and scleritis patients in Malaysia

Seow,

Lee,

Lott

et al. 2024

Int J Ophthalmol

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AIM: To determine the common causes and visual outcome after treatment among uveitis and scleritis patients. METHODS: This is a retrospective cohort observational study. All consecutive clinical records of patients with newly diagnosed uveitis and scleritis over a 4-year period, from Jan. 1, 2017 to Dec. 31, 2020, were analysed. Data was collected at the presentation and included a follow-up period of one year. RESULTS: A total of 288 patients were recruited during the study period. Anterior uveitis was the most common anatomical diagnosis (50.0%) followed by panuveitis (25.0%), scleritis (13.5%), posterior uveitis (6.9%), and intermediate uveitis (4.5%). Viral Herpes was the most common cause of infectious cases, while Vogt-Koyanagi-Harada (VKH) disease and human leucocyte antigen (HLA) B27 spondyloarthropathy were the leading causes of identifiable non-infectious cases. Majority of patients presented with unilateral, non-granulomatous uveitis with an absence of hypopyon. Anatomical locations like posterior uveitis and panuveitis, and visual acuity worse than 3/60 at presentation were the factors associated with poor visual outcomes (P<0.05). About 60% of patients had an identifiable cause for the uveitis and scleritis, with nearly equal distribution of infectious (n=85, 29.5%) and non-infectious causes (n=84, 29.2%). About 14.5% of patients were clinically blind at 1y of follow-up. The most common complication in our uveitis patients was glaucoma (47.5%), followed by cystoid macula oedema (18.9%) and cataract (13.9%). CONCLUSION: Uveitis and scleritis are important causes of ocular morbidity. They are potentially blinding diseases which can have a good outcome if diagnosed and treated early.

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