Ocular Anti-Inflammatory Actions of Matrine

Chuang, Chia‐Ying; Xiao, Jianzhong; Chiou, George C.Y.

doi:10.1089/jop.1987.3.129

Cited by 21 publications

(10 citation statements)

References 7 publications

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“…For example, the previous experimental studies have shown the anti-inflammatory actions of Matrine, the antiangiogenic effect and anti-IL1B expression of Sinomenine, the immune-regulatory effect of Berberine [68–71], and synergistic effects between Matrine and Sinomenine [20], which proved the outputs of our platform. Although the target networks of QLY need to be further experimentally determined, this platform is useful for uncovering the systematic-level mechanisms that are not easily detectable in experimental studies.…”

Section: Discussionsupporting

confidence: 59%

An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula,Qing-Luo-Yin

Zhang

Wang

2013

Evidence-Based Complementary and Alternative Medicine

118

110

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The scientific understanding of traditional Chinese medicine (TCM) has been hindered by the lack of methods that can explore the complex nature and combinatorial rules of herbal formulae. On the assumption that herbal ingredients mainly target a molecular network to adjust the imbalance of human body, here we present a-self-developed TCM network pharmacology platform for discovering herbal formulae in a systematic manner. This platform integrates a set of network-based methods that we established previously to catch the network regulation mechanism and to identify active ingredients as well as synergistic combinations for a given herbal formula. We then provided a case study on an antirheumatoid arthritis (RA) formula, Qing-Luo-Yin (QLY), to demonstrate the usability of the platform. We revealed the target network of QLY against RA-related key processes including angiogenesis, inflammatory response, and immune response, based on which we not only predicted active and synergistic ingredients from QLY but also interpreted the combinatorial rule of this formula. These findings are either verified by the literature evidence or have the potential to guide further experiments. Therefore, such a network pharmacology strategy and platform is expected to make the systematical study of herbal formulae achievable and to make the TCM drug discovery predictable.

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Section: Discussionsupporting

confidence: 59%

An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula,Qing-Luo-Yin

Zhang

Wang

2013

Evidence-Based Complementary and Alternative Medicine

118

110

View full text Add to dashboard Cite

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“…Quinolizidine alkaloids have been found to be its chief active components in Sophora flavescens including matrine, oxymatrine, sophocarpine, sophoridine and other alkaloids (9). Basic and clinical studies have shown that these alkaloids possess a variety of pharmacological effects including anti-inflammation (10,11), immunity-regulation (12), antivirus (6) and antitumor action (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells

et al. 2013

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Abstract. Non-small cell lung carcinoma (NSCLC) is one of the most refractory cancers in the clinic; it is insensitive to chemotherapy and is usually excised. However, screening natural compounds from herbs is also considered a possible method for its therapy. In the present study, we investigated whether matrine, a natural compound isolated from Sophora flavescens Ait. and exerting an inhibitory effect on lung cancer cells, also indicates inhibition on NSCLC cells and elucidated its molecular mechanism. Firstly, it is confirmed that matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose-and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC). Additionally, inhibition of cell proliferation and increase of phosphorylation of p38 was also partially reversed by NAC. Collectively, matrine activates p38 pathway leading to a caspase-dependent apoptosis by inducing generation of ROS in NSCLC cells and may be a potential chemical for NSCLC.

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“…Hence, matrine was used widely in clinical treatment in China (26). Aqueous solution of matrine (1%, w/w) showed significant inhibition of ocular inflammation induced by lens proteins (27). Matrine eye drops can be used to treat the bacterial keratitis and bacterial conjunctivitis (28).…”

Section: Introductionmentioning

confidence: 99%

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

Liu

Zhang

et al. 2010

AAPS PharmSciTech

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Abstract. The objective of this study was to develop an ion-activated in situ gelling vehicle for ophthalmic delivery of matrine. The rheological properties of polymer solutions, including Gelrite, alginate, and Gelrite/alginate solution, were evaluated. In addition, the effect of formulation characteristics on in vitro release and in vivo precorneal drug kinetic of matrine was investigated. It was found that the optimum concentration of Gelrite solution for the in situ gel-forming delivery systems was 0.3% (w/w) and that for alginate solution was 1.4% (w/w). The mixture of 0.2% Gelrite and 0.6% alginate solutions showed a significant enhancement in gel strength at physiological condition. On the basis of the in vitro results, the Gelrite formulations of matrine-containing alginate released the drug most slowly. For each tested polymer solution, the concentration of matrine in the precorneal area was higher than that of matrinecontaining simulated tear fluid (STF) almost at each time point (p<0.05). The area under the curve of formulation 16 (0.2%Gelrite/0.6%alginate) was 4.65 times greater than that of containing matrine STF. Both the in vitro release and in vivo pharmacological studies indicated that the Gelrite/alginate solution had the better ability to retain drug than the Gelrite or alginate solutions alone. The tested formulation was found to be almost non-irritant in the ocular irritancy test. The overall results of this study revealed that the Gelrite/alginate mixture can be used as an in situ gelling vehicle to enhance ocular retention.

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Ocular Anti-Inflammatory Actions of Matrine

Cited by 21 publications

References 7 publications

An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula,Qing-Luo-Yin

An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula,Qing-Luo-Yin

Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells

In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

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