Ocular adnexal lymphoproliferative disorders in an ophthalmic referral center in Saudi Arabia

Alkatan, Hind M.; Alaraj, Ahmad M.; El-khani, Albarah; Al-Sheikh, Osama

doi:10.1016/j.sjopt.2013.07.003

Cited by 14 publications

(10 citation statements)

References 9 publications

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“…[ 14 ] They most commonly present with symptoms from the mass including reduced visual acuity, double vision, ptosis, proptosis, dry eye, and eyelid swelling. [ 15 20 22 ] Pain is a rare clinical feature reported in only 36% of the patients. [ 16 ] On examination, OAL patients were seen to have a conjunctival mass/salmon patch similar to our patient.…”

Section: Discussionmentioning

confidence: 99%

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Ocular adnexal lymphoma presenting with visual loss

et al. 2016

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Context:Elderly patients with visual loss often have age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract as common causes of visual loss. Other less common etiologies should be considered, especially in those presenting with systemic associations.Case Report:The patient discussed in our review is an 80-year-old female, with a history of diabetic retinopathy and macular degeneration who presented with a sudden deterioration of vision. While this was initially attributed to diabetic retinopathy, she was eventually noted to have a salmon patch lesion in her conjunctiva, diagnosed on biopsy to be a diffuse large B-cell lymphoma.Conclusion:Because of the significant rate of disseminated disease among patients with lymphomas in the orbit that carries a worse prognosis, early diagnosis is essential to promote better overall survival of these patients. We describe here a patient diagnosed with conjunctival lymphoma associated with pronounced visual loss and review the literature on this subject.

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Section: Discussionmentioning

confidence: 99%

“…[ 16 ] On examination, OAL patients were seen to have a conjunctival mass/salmon patch similar to our patient. [ 22 23 ] Rarely do these patients have an erosion of the orbital wall, most commonly associated with the DLBCL type. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

Ocular adnexal lymphoma presenting with visual loss

et al. 2016

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“…These lesions exist in a spectrum with atypical lymphoid hyperplasia and lymphomas. With no pathognomonic symptoms, differentiating benign from malignant processes is challenging [ 4 ]. The pathogenesis of ocular adnexal lymphoproliferative lesions has eluded us; however, some cases seem to have association with autoimmune diseases [ 5 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Benign Lymphoid Hyperplasia Presenting as Bilateral Scleral Nodules

Cumba

Vazquez-Botet

2015

Case Reports in Ophthalmological Medicine

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Purpose. To report a case of transient lymphoid hyperplasia presenting as bilateral nodular scleral mass in a young male patient. Design. Observational case report. Methods. Chart review. Causes of scleritis were considered and excluded based on detailed history, physical examination, and laboratory investigations. Results. Excisional biopsy of scleral lesions indicated lymphoid tissue. Immunohistochemical studies revealed a polyclonal population of T and B cells consistent with a benign reactive process. Conclusions. Chronic exposure of the ocular adnexa to many allergens and irritants may lead to activation of the inflammatory cascade. In severely allergic patients activation may be exponential and elicit an immune-mediated response resulting in a transient lymphoid reactive process.

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“…EMZL of mucosa-associated lymphoid tissue (MALT) type is the most common subtype, followed by follicular and diffuse large B-cell lymphoma. C. psittaci , Helicobacter pylori , Borrelia burgdorferi and hepatitis C virus have been linked to MALT lymphomas 6. EMZL usually occurs in fifth to seventh decade and has a female predominance 6…”

Section: Discussionmentioning

confidence: 99%

“…Radiation-induced retinopathy and retinal bleeding usually occur with radiation doses above 40 Gy. Disseminated disease is treated with either chemotherapy (eg, cyclophosphamide, doxorubicin, vincristine and prednisone, ie, CHOP with or without rituximab), immunotherapy (rituximab) or radioimmunotherapy (using 90 Y-ibritumomab tiuxetan) 6. Rituximab is a chimeric monoclonal antibody targeted against the CD20 antigen on B lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

More than meets the eye: the ‘pink salmon patch’

Pallavi

Popescu-Martinez

2014

BMJ Case Reports

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SUMMARYOcular adnexal lymphomas account for 1-2% of all nonHodgkin's lymphomas. Conjunctiva is the primary site of involvement in one-third of cases. We present a case of a 47-year-old Hispanic woman who presented with left eye itching and irritation associated with a painless pink mass. Physical examination revealed the presence of a 'pink salmon-patch' involving her left medial conjunctiva. Orbital CT showed a subcentimeter left preseptal soft tissue density. Biopsy revealed a dense subepithelial lymphoid infiltrate comprised predominantly of B cells that did not coexpress CD5 or CD43. These findings were consistent with B-cell marginal zone lymphoma. Further staging assessment did not reveal disseminated disease. She had stage 1E extranodal marginal zone lymphoma as per Ann Arbor staging system. She received external beam radiotherapy to her left eye with complete resolution of the lymphoma in 2 months and continues to remain tumour free at 8-month follow-up. She will be followed up closely for development of any local (unilateral or contralateral eye) or systemic recurrence in the long run. BACKGROUND

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Ocular adnexal lymphoproliferative disorders in an ophthalmic referral center in Saudi Arabia

Cited by 14 publications

References 9 publications

Ocular adnexal lymphoma presenting with visual loss

Ocular adnexal lymphoma presenting with visual loss

Benign Lymphoid Hyperplasia Presenting as Bilateral Scleral Nodules

More than meets the eye: the ‘pink salmon patch’

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