Ocular Abnormalities and Systemic Disease in Down Syndrome

Kranjc, Branka Stirn

doi:10.3109/09273972.2012.680234

Cited by 43 publications

(33 citation statements)

References 15 publications

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“…Thicker macular structure may be a primary pathology related to the disorder. Stirn et al reported the presence of foveal hypoplasia or retinal pigment epithelium hyperplasia in 32.2 % of patients with Down syndrome [29]. Our data showed that thickening could result from both inner and outer layers, which agrees with this report.…”

Section: Discussionsupporting

confidence: 95%

“…Although there are published reports discussing these issues, much of the current data are considerably variable. For example, Stirn et al noted that among a total of 65 Down syndrome children who visited their hospital, 32 % suffered from abnormalities of the retinal vessels, foveal hypoplasia, or retinal pigment epithelium hyperplasia [29]. Fimiani et al, however, reported retinal anomalies in only 6 % of 157 Italian children with Down syndrome [30].…”

Section: Introductionmentioning

confidence: 97%

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Macular structural characteristics in children with Down syndrome

O'Brien

Wang

Smith

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 97%

Macular structural characteristics in children with Down syndrome

O'Brien

Wang

Smith

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…Astigmatism was 71.0%~84.8% in the children aged under 10 years, and over 90% in subjects in their late teens, that is, higher than that in the previous reports. Reportedly, the percentage of astigmatism ranges from 19 to 72.4 5,6,8,10,14,18–20,22,24,25. However, the percentages in those studies were not even, as the standard value of the definition of astigmatism was not constant.…”

Section: Discussionmentioning

confidence: 98%

“…However, the percentages in those studies were not even, as the standard value of the definition of astigmatism was not constant. High astigmatism, defined as more than 2.0D and 3.0D, has reportedly ranged from 29% to 59% 5,6,14,20. In this study, the mean values were 1.5~2.2 DC and the percentage of astigmatism defined as more than 2.0D was from 33 to 64.…”

Section: Discussionmentioning

confidence: 99%

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Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies

Terai

Eda

Sugasawa

et al. 2018

OPTH

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PurposeTo investigate the age-related development of refractive errors and changes of visual acuity (VA), and the systemic and ocular anomalies in Japanese children and young adults with Down syndrome (DS).DesignRetrospective cohort study.Subjects and methodsThis study involved 222 Japanese children and young adults with DS (age range: 3 months to 19 years) seen at the Department of Ophthalmology, Shiga Medical Center for Children, Shiga, Japan. The subjects were divided into the following six age groups: 1) infant (age 0 to <4 years), 2) preschool (age 4 to <7 years), 3) lower primary-school grades (age 7 to <10 years), 4) upper primary-school grades (age 10 to <13 years), 5) junior high school (age 13 to <16 years), and 6) late teen/young adults (age 16 to <20 years). Through examination of the subjects’ medical charts, we investigated the development and changes of refractive errors and VA, best-corrected VA (BCVA), and systemic and ocular anomalies.ResultsFor vision testing, Teller Acuity Cards™ (Bernell Corporation) were used for the infants, and the Landolt ring was used for the school-age children. VA was found to develop with age. Mean BCVA was 0.19±0.17 logarithm of the minimum angle of resolution (mean age: 11.3±3.2 years). Mean of refractive errors was hyperopia in the infant (2.2±2.4 diopters [D] OD, 2.4±2.5D OS), yet became myopia to the junior high school (−0.3±4.4D OD, −0.2±4.4D OS).ConclusionOur findings revealed that in children and in late-teen and young-adult subjects with DS, VA slowly develops and that refractive errors requiring correction exist and are difficult to examine.

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Ophthalmologic and neuro‐ophthalmologic findings in children with Down syndrome

Jain,

Boyd,

Paulsen

et al. 2023

American J of Med Genetics Pt C

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Down syndrome, also known as Trisomy 21, is a genetic disorder associated with mild‐to‐moderate intellectual disability, delays in growth, and characteristic facial features. A wide range of ocular complications are seen in children with Down syndrome, including strabismus, nystagmus, refractive errors, congenital cataracts, the presence of keratoconus, and decreased visual acuity. Early ophthalmic examination is needed for early diagnosis and treatment in patients. This narrative review examines ocular manifestations in children with Down syndrome and the importance of prompt ophthalmic interventions for treatment.

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Ocular Abnormalities and Systemic Disease in Down Syndrome

Abstract: Comorbidities are common in DS and complicate diagnosis, development, and therapy.

Cited by 43 publications

References 15 publications

Macular structural characteristics in children with Down syndrome

Macular structural characteristics in children with Down syndrome

Ocular findings in Japanese children with Down syndrome: the course of visual acuity and refraction, and systemic and ocular anomalies

Ophthalmologic and neuro‐ophthalmologic findings in children with Down syndrome

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