Octyldodecyl xyloside: a novel contact allergen

Wilkinson, S. M.; Powis, Rachel Ann

doi:10.1111/j.1600-0536.2011.01951.x

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…This allergen is structurally closely related to alkyl glucosides. 24 On the basis of our findings, we recommend patch testing with other alkyl glucosides besides lauryl and decyl glucoside, for example, coco glucoside, cetearyl glucoside, and caprylyl/capryl glucoside.…”

Section: Resultsmentioning

confidence: 84%

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Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous

et al. 2018

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Background Alkyl glucosides contitute a family of mild surfactants that are increasingly being used in a wide range of cosmetics and household products. Contact allergy to alkyl glucosides may be more frequent than previously suspected, especially in atopic patients. Objectives To investigate the frequency of contact allergy to alkyl glucosides, and to identify concomitant reactivity. Method We retrospectively reviewed all cases of suspected allergic contact dermatitis (ACD) in which patients were patch tested with either a cosmetic series that includes five alkyl glucosides (decyl glucoside, lauryl glucoside, coco glucoside, cetearyl glucoside, and caprylyl/capryl glucoside) or a specific alkyl glucoside series from November 2013 to April 2017 in two UK centres. Results A total of 5775 patients were patch tested across the two centres. Twenty‐nine (1.04%) of the 2796 patients tested with the cosmetic/alkyl glucoside series had a positive patch test reaction to at least one of the alkyl glucosides. Twenty‐three (79.3%) patients were sensitized to multiple alkyl glucosides; 21 patients (72.4%) were female. The mean age was 43.5 years. Twelve patients (41.4%) had a background of atopic dermatitis. Conclusions The prevalence of alkyl glucoside‐induced ACD is relatively high, and there are frequent concomitant reactions between different alkyl glucosides. We recommend the inclusion of alkyl glucosides in all cosmetic series.

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Section: Resultsmentioning

confidence: 84%

“…We have previously described a case of contact allergy to octyldodecyl xyloside, a constituent of cosmetic serum. This allergen is structurally closely related to alkyl glucosides …”

Section: Discussionmentioning

confidence: 99%

Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous

et al. 2018

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“…; ++ on D2 and D4); arachidyl alcohol and behenyl alcohol gave negative results, suggesting that arachidyl glucoside was the actual sensitizer. The patient did not react to any other alkyl glucoside tested (coco, decyl, or lauryl), but did react to a cream containing both cetearyl glucoside and octyldodecyl xyloside, the latter of which was described as a possible, but again unproven, cross‐reacting cosmetic allergen by Wilkinson and Powis …”

Section: Discussionmentioning

confidence: 99%

“…The patient did not react to any other alkyl glucoside tested (coco, decyl, or lauryl), but did react to a cream containing both cetearyl glucoside and octyldodecyl xyloside, the latter of which was described as a possible, but again unproven, cross-reacting cosmetic allergen by Wilkinson and Powis. 10 Boozalis and Patel 11 recently queried the 20 best-selling sunscreens and facial moisturizers on Amazon; these results suggested widespread use of alkyl glucosides, with 15% of the sunscreen products and 5% of the facial moisturizers containing arachidyl glucoside.…”

Section: Discussionmentioning

confidence: 99%

Arachidyl glucoside: Another cosmetic allergen

et al. 2018

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“…When asked, l'Oreal mentions three cases of side effects with Substiane® unrelated to Pro‐Xylane™. Allergies to xylose derivatives are rarely reported, and none to hydroxypropyl tetrahydropyrantriol have been reported .…”

Section: Discussionmentioning

confidence: 99%