Octyl gallate has potent anti‐inflammasome activity by directly binding to NLRP3 LRR domain
Hana Park,
Ryeojin Ko,
Jeongin Seo
et al.
Abstract:The NOD‐, LRR‐, and Pyrin domain‐containing protein 3 (NLRP3) inflammasome plays key roles in regulating inflammation. Numerous studies show that the abnormal activation of NLRP3 associates with the initiation and progression of various diseases. Hence, the NLRP3 inflammasome may be a promising therapeutic target for these diseases. Octyl gallate (OG) is a small molecule with antioxidant, antimicrobial, antifungal, and anti‐inflammatory activities; however, the mechanism underlying its anti‐inflammatory activi… Show more
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