Octyl-cyanoacrylate skin adhesive is effective for wound closure in posterior spinal surgery without increased risk of wound complications

Howard, Brian M.; Eshraghi, Sheila R.; Holland, Christopher M.; Refai, Daniel

doi:10.1016/j.clineuro.2014.07.026

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…In all, 97 articles were excluded after full text screening. The study by Howard et al 9 was excluded as patients with cyanoacrylate wound closure also simultaneously underwent skin closure with subcuticular monocryl suture. A citation and bibliographic search of the remaining articles resulted in one additional article for inclusion.…”

Section: Resultsmentioning

confidence: 99%

Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

Tan

Rutges

Marion

et al. 2019

Global Spine Journal

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Study Design: Systematic review. Objectives: Cyanoacrylate glue closure has been utilized for dermal closure in surgical incisions. Its safety and efficacy in spine surgery are not established. The authors perform a systematic review to determine the rate of surgical site infection (SSI), wound dehiscence, and wound erythema with cyanoacrylate dermal closure in spine surgery. Methods: A systematic review adhering to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed utilizing the PubMed/MEDLINE, EMBASE, and Cochrane databases on patients undergoing spine surgery with cyanoacrylate dermal closure. Pooled analysis was performed with stratification of patients according to spinal level and the presence/absence of instrumentation. Risk-of-bias and methodological quality was appraised using 17 prespecified criteria. Results: Five articles (1 retrospective cohort study, 4 cases series) with a total of 1282 patients were included. A total of 967 patients, all diagnosed with degenerative spine disease, were suitable for pooled analysis. In 290 patients who underwent anterior cervical discectomy and fusion, and in 23 patients with posterior cervical decompression (without instrumentation), there was 0% rate of SSI, wound dehiscence, and erythema. In 489 patients who underwent lumbar microdiscectomy, there was 0.41% rate of SSI, 0.20% rate of wound dehiscence, and 0.20% rate of wound erythema. In 165 lumbar laminectomy patients, there was a 1.82% rate of SSI, 0.61% rate of wound dehiscence, and 0% rate of wound erythema. Conclusion: Cyanoacrylate dermal closure for the aforementioned procedures is associated with low rates of wound complications (SSI, dehiscence, and erythema). Further studies should be performed, especially in nondegenerative surgery, instrumented thoracic and lumbar spine surgery.

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Section: Resultsmentioning

confidence: 99%

Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

Tan

Rutges

Marion

et al. 2019

Global Spine Journal

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“…To cater to fast rehabilitation and cosmetic need, some surgeons introduced the tissue adhesive in orthopedic surgeries. [17][18][19] But the clinical study on the comparison with subcuticular suture in joint surgery was rare. 10,[20][21][22] Roumeliotis and Graham reported that tissue adhesive with subcuticular suture application was a viable option for skin closure after lower limb arthroplasty and can reduce the incidence of prolonged wound discharge.…”

Section: Discussionmentioning

confidence: 99%

“…To cater to fast rehabilitation and cosmetic need, some surgeons introduced the tissue adhesive in orthopedic surgeries. 17 – 19 But the clinical study on the comparison with subcuticular suture in joint surgery was rare. 10 , 20 - 22…”

Section: Discussionmentioning

confidence: 99%

<p>A Prospective, Randomized and Controlled Study on Tissue Adhesive for Skin Incision in Total Knee Arthroplasty</p>

Kong¹,

Yang²,

Guo³

et al. 2020

TCRM

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Background: The study focusing on the tissue adhesive in total knee arthroplasty (TKA) was rare. This study aimed to evaluate the clinical outcomes and economic costs of tissue adhesive when acting as the adjunct to standard incision closure in TKA. Patients and Methods: From September 2019 to November 2019, we prospectively enrolled the consecutive patients who underwent simultaneous bilateral TKA in our institute. The allocation using the tissue adhesive was done after the subcuticular suture in right knee first and another method was applied in the left knee automatically. The patients' demographics, length of stay (LOS), times of dressing changes and incision-related cost, range of motion (ROM), incision-related complications and incision evaluation scores were recorded. Results: Thirty-two patients were enrolled in this study and followed at two months after surgery. In the knees of tissue adhesive, the times of dressing change and patient scar assessment scores (PSAS) were significantly less than those standard skin closure (p=0.000; p=0.003). Although there were no significant differences of the delayed discharge, incision-related cost, ROM, incision-related complications and Vancouver scar score (VSS) between two groups, 65.6% (21/32) patients preferred the tissue adhesive and only 15.6% (5/ 32) patients preferred the standard incision closure. Conclusion: Tissue adhesive could effectively reduce postoperative wound drainage and improve patients' satisfaction rate with no difference in medical costs and ROM in TKA. The application of tissue adhesive and subcuticular sutures might be one safe and convenient method of skin closure in TKA.

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“…The biocompatibility of 2-octyl cyanoacrylate with tissues has been describedin the tissue repair process. Although the literature demonstrates tissue reactions associated with cyanoacrylate use, there are no studies concerning the application of low-power laser therapy on wounds sutured with 2-octyl cyanoacrylate [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…2-octyl cyanoacrylate is a biological glue, composed of a carbonic chain thatcan be used as a suture in regions where initial healing is expected to take place. The same occlusive layer covers the wound surface and extends to one centimetre above the edge of the incision [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tissue Response in Sites Sutured with Cyanoacrylate and Submitted to Low Power Laser Therapy: A Randomized Clinical Trial

Andrade

Zerbinati

Oliveira

2019

JDMS

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This study aimed to qualitatively evaluate the inflammatory response in sites sutured with nylon and 2-octyl cyanoacrylate and submitted to low-power laser therapy. Background: 2-octyl cyanoacrylate acts as both a bonding agent for incisional wounds and a substitute for conventional suture methods after topical application, forming an occlusive layer that prevents the entry of any exogenous agent into the wound. Tissue reactions such as granuloma formation are cited in the literature as possible outcomes following 2-octyl cyanoacrylate use. Methods: Thirty wistar rats, were randomized into groups of five, of which fifteen were sutured with 2-octyl cyanoacrylate and another fifteen with nylon thread. In the postoperative period, all the animals were submitted to low power laser therapy in a single centralised region, with light perpendicular to the surgical wound, applied every 48 hours via the ArGaAl laser, with a wavelength of 685nm, a dose of 4J/cm2 and power level of 35mW. All the animals were kept in separate cages, under similar conditions, and provided with water and ad libitum feed. Animals were euthanized at 1 day (D1), 3 days (D2) and 7 days (D3). Tissue samples were removed from the central region of the wound and the slides were stained with hematoxylin and eosin. Results: Histological sections were analysed by evaluating inflammatory parameters and in accordance with a previously standardized scale. Similar inflammatory reactions were observed between sutured wounds with nylon and cyanoacrylate, with no statistically significant differences observed. Conclusions: Results suggest that there is no difference in the association between 2-octyl cyanoacrylate and laser therapy and nylon sutures with and the same As-Ga-Al laser application dosage

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Octyl-cyanoacrylate skin adhesive is effective for wound closure in posterior spinal surgery without increased risk of wound complications

Cited by 9 publications

References 19 publications

Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

<p>A Prospective, Randomized and Controlled Study on Tissue Adhesive for Skin Incision in Total Knee Arthroplasty</p>

Evaluation of Tissue Response in Sites Sutured with Cyanoacrylate and Submitted to Low Power Laser Therapy: A Randomized Clinical Trial

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