Octreotide Effects on Orthostatic Hypotension in Patients with Multiple System Atrophy

Bordet, Régis; Benhadjali, J.; Destée, Alain; Belabbas, A.; Libersa, C

doi:10.1097/00002826-199502000-00012

Cited by 45 publications

(23 citation statements)

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“…[484][485][486][487] Octreotide reduces splanchnic blood flow by approximately 20%, 486 which prevents postprandial hypotension, increases blood pressure, and improves orthostatic tolerance. [484][485][486][487] return to the heart drops, with a resultant decrease in cardiac output. 31 Normally, the autonomic nervous system provides compensatory changes in vascular tone, heart rate, and cardiac contractility.…”

Section: -487mentioning

confidence: 99%

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Sheldon²,

et al. 2017

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Section: -487mentioning

confidence: 99%

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

Sheldon²,

et al. 2017

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“…Octreotide has been used mainly to correct postprandial hypotension linked to OH (Hoeldtke and Israel, 1989), as it could counter the release of vasoactive peptides secreted with food/alcohol ingestion (Bordet et al, 1995; Chaudhuri et al, 1995; Hoeldtke et al, 1998). Its combination with midodrine was more effective than when it was given alone (Hoeldtke and Israel, 1989).…”

Section: Therapeutic Measuresmentioning

confidence: 99%

The Management of Orthostatic Hypotension in Parkinson’s Disease

2013

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Orthostatic hypotension (OH) is a common and disabling symptom affecting Parkinson’s disease (PD) patients. We present the effect of the different therapies commonly used to manage PD on this clinical manifestation. For this purpose, we describe the relationship between OH and the current treatments employed in PD, such as L-DOPA, dopaminergic agonists, and continuous dopaminergic stimulation therapies. Additionally, we review the therapeutic measures that could be used to ameliorate OH. There are different approaches to deal with this manifestation, including pharmacological and non-pharmacological treatments, although none of them is specifically aimed for treating OH in PD.

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“…Octreotide has been shown to delay the time of blood pressure fall with upright tilt in a group of patients with MSA 68 . However, this medication has limited utility due to parenteral administration and side effects of diarrhea, abdominal pain and hyperglycemia.…”

Section: Treatment Of Orthostatic Hypotensionmentioning

confidence: 98%

Orthostatic hypotension: managing a difficult problem

Jones¹,

Shaw

Raj

2015

Expert Review of Cardiovascular Therapy

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SUMMARYOrthostatic hypotension (OH) leads to a significant number of hospitalizations each year, and is associated with significant morbidity and mortality among affected individuals. Given the increased risk for cardiovascular events and falls; it is important to identify the underlying etiology of OH and to choose appropriate therapeutic agents. Orthostatic hypotension can be nonneurogenic or neurogenic (arising from a central or peripheral lesion). The initial evaluation includes orthostatic vital signs, complete history and a physical. Patients should also be evaluated for concomitant symptoms of post-prandial hypotension and supine hypertension. Nonpharmacologic interventions are the first step for treatment of OH. The appropriate selection of medications can also help with symptomatic relief. This review highlights the pathophysiology, clinical features, diagnostic workup and treatment of patients with neurogenic OH.

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Octreotide Effects on Orthostatic Hypotension in Patients with Multiple System Atrophy

Cited by 45 publications

References 0 publications

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society

The Management of Orthostatic Hypotension in Parkinson’s Disease

Orthostatic hypotension: managing a difficult problem

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