Octreotide Bolus Injection and Azygos Blood Flow in Patients With Cirrhosis

Abstract

The AzBF showed a sustained decrease of value after a bolus injection of 50-μg OCT. A further hemodynamic response is detectable at OCT readministration after 60 minutes. The pattern of hemodynamic response to OCT may not be uniform among cirrhotics.

Prediction of octreotide efficacy by electrogastrography in the treatment of patients with esophageal variceal hemorrhage

“…Although the exact mechanism of the action of octreotide remains unclear, results of our study confirm that it might have direct inhibitory effect on the gastrointestinal myoelectrical activity. In addition, octreotide cause splanchnic venous vasoconstriction (Chandok et al 2012), decrease portal pressure (Spahr et al 2010) and inhibit the secretion of gastrointestinal hormone (Baik et al 2005), such as glucagons, cholecystokinin, gastrin and so on, which may participate in the inhibitory effect on gastrointestinal myoelectricity (Katoh et al 2003, Budzynski et al 2002.…”

“…Octreotide treatment is safe, effective and can allow optimized elective endoscopic therapy a few hours later (Zuberi and Baloch 2000), so it is considered first in EVH emergency. Although a number of studies have investigated a variety of dosage of octreotide in the treatment of EVH patients (Vlachogiannakos et al 2007, Baik et al 2005, Zhou et al 2002, a consensus on an optimal dosage and routine administration has not been achieved, because of the lack of a convenient and effective method for the early evaluation of efficacy (Spahr et al 2010).…”