Octreotide and Octreotide-derived delivery systems

Toward tryptathionine-stapled one-bead-one-compound (OBOC) libraries: solid phase synthesis of a bioactive octretoate analog

“…The fluorescence also appeared to show some uptake within certain cells, which is consistent with agonistic activity of TATE that is known to cargo-in larger molecules. 18 While Ar42J cells are the standard cell-line used for probing TATE analogs, unfortunately, these cells grew as clusters, and stronger fluorescent signal was logically observed in cells at the top or edges of the clusters. Despite a significant reduction of affinity toward SST 2 receptor, the green fluorescent EDANS-oxime-Ttn-TATE 9 stained live Ar42J cells, consistent with the production of a bioactive bead-bound analog.…”