Octogenarians Develop Infrapopliteal Arterial Occlusive Disease in the Absence of Traditional Risk Factors

Hylton, Jared R.; Smith, Caitlin; Li, Chin‐Shang; Pevec, William C.

doi:10.1016/j.avsg.2014.04.005

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Besides age (Hylton 2014;Ostchega 2007), the most important clinical predictors for CLI progression are smoking and diabetes (Howard 2015). The risk associated with smoking applies to all ages and increases with the number of cigarettes smoked.…”

Section: Description Of the Conditionmentioning

confidence: 99%

Prostanoids for critical limb ischaemia

Vietto

Franco

Sáenz

et al. 2018

Cochrane Database of Systematic Reviews

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We found high-quality evidence showing that prostanoids have no effect on the incidence of total amputations when compared against placebo. Moderate-quality evidence showed small beneficial effects of prostanoids for rest-pain relief and ulcer healing when compared with placebo. Additionally, moderate-quality evidence showed a greater incidence of adverse effects with the use of prostanoids, and low-quality evidence suggests that prostanoids have no effect on cardiovascular mortality when compared with placebo. None of the included studies reported quality of life measurements. The balance between benefits and harms associated with use of prostanoids in patients with critical limb ischaemia with no chance of reconstructive intervention is uncertain; therefore careful assessment of therapeutic alternatives should be considered. Main reasons for downgrading the quality of evidence were high risk of attrition bias and imprecision of effect estimates.

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Section: Description Of the Conditionmentioning

confidence: 99%