Octenidine dihydrochloride: chemical characteristics and antimicrobial properties

Assadian, Ojan

doi:10.12968/jowc.2016.25.sup3.s3

Cited by 60 publications

(53 citation statements)

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“…Finally, it must be pointed out that, among the identified trials comparing the bacterial reduction of AP against treatment modalities without AP one trial, Ulrich and colleagues 8 used a control study arm in which a combination of 0.1% octenidine-dihydrochloride and 2% 2-phenoxyethanol (OCT; Octenisept, Schuelke GmbH, Norderstedt, Germany) was applied. 48 The statistical design of this RCT was a noninferiority study showing that AP achieved a significantly inferior bacterial reduction compared with the wound antiseptic used as a control. The weight of this study in the context of the conducted meta-analysis was 15.7% and could have potentially biased the outcome results for bacterial reduction in favour of the control.…”

Section: Discussionmentioning

confidence: 99%

Effects and safety of atmospheric low‐temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta‐analysis

Assadian

Ousey

Daeschlein

et al. 2018

International Wound Journal

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The use of atmospheric low‐temperature plasma (AP) on chronic wounds and its effect on microbial bioburden in open wounds has not been explored with a systematic review and meta‐analysis. PRISMA guidelines were followed and PubMed, Embase, CENTRAL, and CINAHL databases searched for randomised controlled trials (RCTs), which compared AP with no AP for the management of open, chronic wounds. The primary outcomes of reduction of bioburden or wound size were included. Meta‐analyses were performed; odds ratio (OR) and 95% confidence intervals (CIs) were extracted and pooled in a random effects model. Four RCTs investigated the effect of AP on chronic wound healing. Chronic wounds treated with AP did not show a significant improvement in healing (AP vs control: OR = 1.46; 95% CI = 0.89‐2.38; P = 0.13). Five further RCTs investigated the reduction of bioburden in wounds, but AP demonstrated no significant reduction of bioburden (AP vs control: OR = 0.85; 95% CI = 0.45‐1.62; P = 0.63). All nine RCTs recorded the presence of any severe adverse events (SAEs) in the 268 patients studied, with only one unrelated SAE identified in each group (AP vs control: OR = 1.00; 95% CI = 0.05‐19.96; P = 1.00). Use of AP in wound care is safe, but the retrieved evidence and meta‐analysis show that there is no clinical benefit of AP in chronic open wounds using currently available AP device settings.

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Section: Discussionmentioning

confidence: 99%

Effects and safety of atmospheric low‐temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta‐analysis

Assadian

Ousey

Daeschlein

et al. 2018

International Wound Journal

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“…Finally, we tested whether P. aeruginosa secreted products could increase the anti-staphylococcal efficacy of octenidine dihydrochloride, a surfactant-based antiseptic that is approved for treatment of wound infections and has low cytotoxicity (78, 79). We observed that P. aeruginosa supernatant potentiates the activity of octenidine against S. aureus biofilms by 2.5 logs (Fig.…”

Section: Resultsmentioning

confidence: 99%

Pseudomonas aeruginosaincreases the sensitivity of biofilm-grownStaphylococcus aureusto membrane-targeting antiseptics and antibiotics

Orazi

Ruoff

O’Toole

2019

Preprint

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16Structured abstract word count: (Abstract: 217; Importance: 143) Abstract 19Pseudomonas aeruginosa and Staphylococcus aureus often cause chronic, recalcitrant infections 20 in large part due to their ability to form biofilms. The biofilm mode of growth enables these 21 organisms to withstand antibacterial insults that would effectively eliminate their planktonic 22 counterparts. We found that P. aeruginosa supernatant increased the sensitivity of S. aureus 23 biofilms to multiple antimicrobial compounds, including fluoroquinolones and membrane-24 targeting antibacterial agents, including the antiseptic chloroxylenol. Treatment of S. aureus with 25 the antiseptic chloroxylenol alone did not decrease biofilm cell viability; however, the 26 combination of chloroxylenol and P. aeruginosa supernatant led to a 4-log reduction in S. aureus 27 biofilm viability compared to exposure to chloroxylenol alone. We found that the P. aeruginosa-28 produced small molecule 2-n-heptyl-4-hydroxyquinoline N-oxide (HQNO) is responsible for the 29 observed heightened sensitivity of S. aureus to chloroxylenol. Similarly, HQNO increased the 30 susceptibility of S. aureus biofilms to other compounds, including both traditional and non-31 traditional antibiotics, which permeabilize bacterial membranes. Genetic and phenotypic studies 32 support a model whereby HQNO causes an increase in S. aureus membrane fluidity, thereby 33 improving the efficacy of membrane-targeting antiseptics and antibiotics. Importantly, our data 34 show that P. aeruginosa exoproducts can enhance the ability of various antimicrobial agents to 35 kill biofilm populations of S. aureus that are typically difficult to eradicate, providing a path for 36 the discovery of new biofilm-targeting antimicrobial strategies. 37 38 Importance 39The thick mucus in the airways of cystic fibrosis (CF) patients predisposes them to frequent, 40 polymicrobial respiratory infections. Pseudomonas aeruginosa and Staphylococcus aureus are 41 frequently co-isolated from the airways of individuals with CF, as well as from diabetic foot 42 ulcers and other wounds. Both organisms form biofilms, which are notoriously difficult to 43 eradicate and promote chronic infection. In this study, we have shown P. aeruginosa secreted 44 factors can increase the efficacy of compounds that alone have little or no bactericidal activity 45 against S. aureus biofilms. In particular, we discovered that P. aeruginosa exoproducts can 46 potentiate the anti-staphylococcal activity of phenol-based antiseptics and other membrane-47 active drugs, including non-traditional antibiotics. Our findings illustrate that polymicrobial 48 interactions can dramatically increase antibacterial efficacy in vitro, and may guide new 49 approaches to target persistent infections, such as those commonly found in respiratory tract 50 infections and in chronic wounds. 51 52 Introduction 53Bacterial biofilms are the underlying cause of many chronic, difficult-to-treat infections. The 54 biofilm lifestyle confers high-level tolerance t...

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“…Positive cultures in swab cultures taken on clinical grounds at follow-up visits were more infrequent than in those taken at study entry. Both treatment agents applied in present study are known to be antiseptics in vitro against a broad spectrum of microbes [6][7][8][9]. Control of infection is one of the key issues in successful wound care in general [14].…”

Section: Discussionmentioning

confidence: 99%

“…Abilar ® 10% Resin Salve is a newer topical antiseptic ulcer agent in formulation of salve, and shows effectiveness in treatment of pressure wounds and complicated surgical wounds [4,5]. Despite different formulation, both are antiseptics, and the microbicidal mechanisms of agents, solution and salve, are likely similar in that they both are thought to work via unspecific destruction of the microbial cell wall and cell membrane [6][7][8][9]. They may also enhance skin regrowth and regeneration [4,5].…”

Section: Introductionmentioning

confidence: 99%

Healing of Neuropathic Diabetic Foot Ulcers of PEDIS Grade 1-2 at Home Care with Topical Antiseptics: An Observational Follow-Up Investigation

Korzon-Burakowska¹,

Przeździak²,

Orłowska-Kunikowska³

et al. 2017

J Clin Exp Dermatol Res

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Objective: This observational and clinical prospective follow-up study examined the healing of ordinary diabetic foot ulcers at home-care setting with two commercially available topical antiseptics, one in formulation as a solution and the other one as a salve. Method:The study population consisted of 35 consecutive adult outpatients with diabetic foot ulcers that were classified as grades 1-2 by using the PEDIS (Perfusion, Extent, Depth, Infection and Sensation) classification system. The patients were treated by two commercial antiseptics (Abilar ® 10% Resin Salve or Octenidine ® solution) and followed-up by a specialized clinic with four follow-up visits during a treatment period of 145 days on average. All patients performed the wound care at home after instructions from the clinic.Results: At study entry, the mean ulcer area was 221 mm 2 (median 140 mm 2 , interquartile range: 73-320 mm 2 ) in the salve group and 277 mm 2 (median 132 mm 2 , interquartile range: 50-365 mm 2 ) in the solution group. In intentto-treat (ITT) analysis of the whole study population of 35 patients, the ulcers healed totally in 14 (37%; 95% CI 24-56%), and in 9 of 19 patients (47%; 95% CI: 25%-77%) and in 5 of 16 patients (31%; 95% CI: 9%-54%) in the resin salve and Octenidine solution groups, respectively (P>0.05). The infected ulcer with small median size showed an insignificant trend to heal better than the other ulcers. The number of positive bacterial cultures from ulcers (bacteria of Staphylococcus and Streptococcus species in great majority of cases), taken on clinical grounds if infection was suspected, was lower in follow-up visits than at study entry. No side effects were observed. Conclusion:Treatment of diabetic foot ulcers of PEDIS grade 1-2 at home-care with topical antiseptics is an option that results in complete healing of ulcer in more than one third of cases in a 145-day treatment period.

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Octenidine dihydrochloride: chemical characteristics and antimicrobial properties

Cited by 60 publications

References 0 publications

Effects and safety of atmospheric low‐temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta‐analysis

Effects and safety of atmospheric low‐temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta‐analysis

Pseudomonas aeruginosaincreases the sensitivity of biofilm-grownStaphylococcus aureusto membrane-targeting antiseptics and antibiotics

Healing of Neuropathic Diabetic Foot Ulcers of PEDIS Grade 1-2 at Home Care with Topical Antiseptics: An Observational Follow-Up Investigation

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