Octadentate flexible ligands as a platform for a variety of homo and heterometallic complexes containing diphenoxido and phenoxido/azido bridging groups: synthesis, structure and magnetic properties

Pramanik, Koushik; Malpaharia, Pijush; Colacio, Enrique; Das, Babulal; Chandra, Swapan K.

doi:10.1039/c7nj05112c

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…The synthesis of mononuclear metal complexes with octadentate Schiff base ligands still remains a difficult challenge. The octadentate Schiff base ligands are, indeed, much more suitedto construct di-and multinuclear metal complexes[344][345][346][347][348][349][350][351][352][353][354][355][356][357][358][359]. This class of compounds that represents a broad area of research has not been discussed in this review.…”

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confidence: 99%

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Liu

Hamon

2019

Coordination Chemistry Reviews

309

137

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Novel ligand platforms that promote reactivity are of long standing and continued interest in coordination chemistry, with Schiff base ligands and their metal complexes representing one of the most versatile and long standing topics of interest. The synthesis and structure of polydentate Schiff bases and their metal complexes is fascinating, because it reveals a great richness of structural, physico-chemical and catalytic properties. Given the simplicity and ease of access to multidentate Schiff bases and their metal complexes, investigation of such compounds is essential to precise and understand structure-property relationships in order to optimize and improve their use in a wide range of fields, including catalysis, supramolecular chemistry, magnetism, electrochemistry, nanoscience, energy materials, and biological applications. This review highlights the recent developments of pentadentate, hexadentate, heptadentate and macrocyclic Schiff base ligands containing various donor sets made of different combinations of N, O, S or P donor atoms and their metal complexes (essentially mononuclear), as well as presenting synthetic methods and interesting structures of complexes formed by first-to-third row transition metals (from group 4-12), main group elements, lanthanides and actinides. This review is divided into three main sections, each of them corresponding to one type of denticity of the Schiff base under consideration. Each category is described with representative examples according to a periodic order, and emphasis is given to the coordination aspects. Their catalytic, magnetic and biological properties are also outlined. This review that contains 359 references should act as a source of information to researchers interested to work in this domain and stimulate further investigation in this fascinating area of Schiff base coordination compounds.

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confidence: 99%

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Liu

Hamon

2019

Coordination Chemistry Reviews

309

137

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“…Scientists have explored a series of Schiff bases derived from 2-mercapto-3-formyl quinoline/2hydroxy-3-formyl quinoline with 2,6diaminopyridine (DAP) and their corresponding Co (II), Ni (II), Cu (II) and Zn (II) complexes for their anti-inflammatory activity. The Cu (II) complexes showed the highest biological activities amongst the compounds tested [51].…”

Section: Anti-inflammatory Agentsmentioning

confidence: 97%

Dynamics of Transition Metal and their Application in Biomedical Industry

Malpaharia¹,

Pandey²

2020

Int.J.Curr.Microbiol.App.Sci

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“…Schiff bases are important compounds in chemistry and biochemistry due to their flexibility (Mayans et al, 2018;Pramanik et al, 2018), easy preparation (Erxleben, 2018;ISSN 2053ISSN -2296 # 2020 International Union of Crystallography Ganguly et al, 2014), exceptional chelating ability (Malik et al, 2018;Vardhan et al, 2015) and to their broad spectrum of biological and pharmaceutical activities, such as antimicrobial (Anush et al, 2018;Unver & Bektas, 2018;Bharathi et al, 2018;Carreñ o et al, 2018), anti-inflammatory (Venkatesan et al, 2018;Farag et al, 2017;Bano et al, 2017;Khayyat et al, 2015) and anticancer properties (Unver & Bektas, 2018;Santhosh Kumar et al, 2018;Kalaiarasi et al, 2018;Ariyaeifar et al, 2018). Thus, the chemistry of Schiff bases has always been a promising field of research.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structures, antiproliferative activities and reverse docking studies of eight novel Schiff bases derived from benzil

et al. 2020

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Eight novel Schiff bases derived from benzil dihydrazone (BDH) or benzil monohydrazone (BMH) and four fused-ring carbonyl compounds (3-formylindole, FI; 3-acetylindole, AI; 3-formyl-1-methylindole, MFI; 1-formylnaphthalene, FN) were synthesized and characterized by elemental analysis, ESI–QTOF–MS, 1H and 13C NMR spectroscopy, as well as single-crystal X-ray diffraction. They are (1Z,2Z)-1,2-bis{(E)-[(1H-indol-3-yl)methylidene]hydrazinylidene}-1,2-diphenylethane (BDHFI), C32H24N6, (1Z,2Z)-1,2-bis{(E)-[1-(1H-indol-3-yl)ethylidene]hydrazinylidene}-1,2-diphenylethane (BDHAI), C34H28N6, (1Z,2Z)-1,2-bis{(E)-[(1-methyl-1H-indol-3-yl)methylidene]hydrazinylidene}-1,2-diphenylethane (BMHMFI) acetonitrile hemisolvate, C34H28N6·0.5CH3CN, (1Z,2Z)-1,2-bis{(E)-[(naphthalen-1-yl)methylidene]hydrazinylidene}-1,2-diphenylethane (BDHFN), C36H26N4, (Z)-2-{(E)-[(1H-indol-3-yl)methylidene]hydrazinylidene}-1,2-diphenylethanone (BMHFI), C23H17N3O, (Z)-2-{(E)-[1-(1H-indol-3-yl)ethylidene]hydrazinylidene}-1,2-diphenylethanone (BMHAI), C24H19N3O, (Z)-2-{(E)-[(1-methyl-1H-indol-3-yl)methylidene]hydrazinylidene}-1,2-diphenylethanone (BMHMFI), C24H19N3O, and (Z)-2-{(E)-[(naphthalen-1-yl)methylidene]hydrazinylidene}-1,2-diphenylethanone (BMHFN) C25H18N2O. Moreover, the in vitro cytotoxicity of the eight title compounds was evaluated against two tumour cell lines (A549 human lung cancer and 4T1 mouse breast cancer) and two normal cell lines (MRC-5 normal lung cells and NIH 3T3 fibroblasts) by MTT assay. The results indicate that four (BDHMFI, BDHFN, BMHMFI and BMHFN) are inactive and the other four (BDHFI, BDHAI, BMHFI and BMHAI) show severe toxicities against human A549 and mouse 4T1 cells, similar to the standard cisplatin. All the compounds exhibited weaker cytotoxicity against normal cells than cancer cells. The Swiss Target Prediction web server was applied for the prediction of protein targets. After analyzing the differences in frequency hits between these active and inactive Schiff bases, 18 probable targets were selected for reverse docking with the Surflex-dock function in SYBYL-X 2.0 software. Three target proteins, i.e. human ether-á-go-go-related (hERG) potassium channel, the inhibitor of apoptosis protein 3 and serine/threonine-protein kinase PIM1, were chosen as the targets. Finally, the ligand-based structure–activity relationships were analyzed based on the putative protein target (hERG) docking results, which will be used to design and synthesize novel hERG ion channel inhibitors.

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Octadentate flexible ligands as a platform for a variety of homo and heterometallic complexes containing diphenoxido and phenoxido/azido bridging groups: synthesis, structure and magnetic properties

Abstract: Homometallic (M2 and M4) and heterometallic (Ni4Cu) complexes were assembled from octadentate Schiff-base ligands, transition metal ions and ancillary ligands.

Cited by 7 publications

References 48 publications

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Dynamics of Transition Metal and their Application in Biomedical Industry

Synthesis, crystal structures, antiproliferative activities and reverse docking studies of eight novel Schiff bases derived from benzil

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