Octacosanol affects lipid metabolism in rats fed on a high-fat diet

Abstract

The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0.05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3.1.3.4). Though the activity of hormone-sensitive lipase (EC 3.1.1.3) was not influenced by octacosanol, higher activities of lipoprotein liyase (EC 3.1.1.34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.

Time-Dependent Effects of a High-Energy-Yielding Diet on the Regulation of Specific White Adipose Tissue Genes

“…High-fat feeding was used to generate diet induced obesity as previously described (23,24). Rats eating such a diet, increased energy intake, body weight and adiposity, which is in good accordance with previous data (25).…”

Characterization of rice bran wax policosanol and its nanoemulsion formulation

“…The remaining 15% is made up of other alcohols, namely, tetracosanol, heptacosanol, docosanol, nonacosanol, and tetratriacontanol, which are the minor components. 16 Several reports, including many clinical trials, have shown that policosanols have significant health-promoting activities such as the reduction of lipid levels, [17][18][19][20][21] platelet aggregation reduction, 22 antiviral activity, 23 reduction of prostate enlargement, and relief of intermittent claudication. 24 In contrast, there are conflicting findings about the efficacy of policosanol, particularly with regard to lowering lipid levels.…”

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“…n-octacosanol isolated from Tinospora is useful in improving endurance and increasing oxygen utilization 4 . Limited studies suggest that n-octacosanol works to reduce blood cholesterol 5 and helps to treat the patients suffering from coronary heart diseases 6 , Parkinson's disease 7,8,9 . Hence, in the present study, an attempt was made to select an appropriate genotype that produces maximum amount of n-octcosanol.…”