Octacalcium phosphate: Innovative vehicle for the local biologically active substance delivery in bone regeneration

Kovrlija, Ilijana; Ločs, Jānis; Loča, Dagnija

doi:10.1016/j.actbio.2021.08.021

Cited by 35 publications

(17 citation statements)

References 196 publications

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“…Calcium phosphates have been widely utilized in orthopaedics due to their similarity to native bone tissues in terms of mineral composition. 1 Compared with crystalline phases such as hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ), 2 tricalcium phosphate (TCP, Ca 3 (PO 4 ) 2 ), 3,4 and octacalcium phosphate (OCP, Ca 8 H 2 (PO 4 ) 6 •5H 2 O), 5 amorphous calcium phosphates (ACPs) 6 have been favoured by researchers due to their unique characteristics. In spite of its amorphous nature, EXAFS spectroscopy has confirmed the short-range ordered structure in ACPs, which could convert into the long-range order after enough maturation.…”

Section: Introductionmentioning

confidence: 99%

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Wang

Sun

et al. 2022

CrystEngComm

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Section: Introductionmentioning

confidence: 99%

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Wang

Sun

et al. 2022

CrystEngComm

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“…[ 16 ] Therefore, it is necessary to evaluate the bioactivity of the PEEK/CSw composites in vitro through measuring the ability to form bone‐like hydroxyapatite (HA) layer on the surface in SBF. [ 17 ] Figure S2a–d (Supporting Information) shows SEM images of the mineralization formation of bone‐like HA on the surfaces of pure PEEK and the PEEK/CSw composites. No obvious mineralization deposition of HA was observed on the surface of pure PEEK due to the bio‐inertness together with hydrophobicity.…”

Section: Resultsmentioning

confidence: 99%

Calcium Silicate Whiskers‐Enforced Poly(Ether‐Ether‐Ketone) Composites with Improved Mechanical Properties and Biological Activities for Bearing Bone Reconstruction

Wang

Lei

et al. 2022

Macromolecular Bioscience

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Poly (ether-ether-ketone) (PEEK) displays promising potential application in bone tissue repair and orthopedic surgery due to its good biocompatibility and chemical stability. However, the bio-inertness and poor mechanical strength of PEEK greatly limit its application in load-bearing bones. In this study, calcium silicate whiskers (CSws) are synthesized and then compounded with PEEK to fabricate the PEEK/CSw composites with excellent mechanical properties, biological activity. Compared with PEEK, the PEEK/CSw composites exhibited higher hydrophilicity and ability to deposit hydroxyapatite on the surface. CSws are evenly dispersed in the PEEK matrix at 10 wt% content and the mechanical strength of the PEEK/CSw composite is ≈96.9 ± 2.4 MPa, 136.3 ± 2.4 MPa, and 266.0 ± 3.2 MPa, corresponding to tensile strength, compressive strength, and bending strength, respectively, which is 20%, 18%, and 52% higher than that of pure PEEK. The composites improve the adhesion, proliferation, and osteogenic differentiation of BMSCs. Furthermore, PEEK/CSw composite remarkably improves bone formation and osteointegration, which has higher bone repair capacity than PEEK. These results demonstrate that the PEEK/CSw scaffolds display superior abilities to integrate with the host bone and promising potential in the field of load bearing bone repair.

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“…To generate nanocrystalline HAp domains in a restricted space rich in citrate and lactate anions, we exploit the well-known transformation of OCP to HAp [25][26][27][28][29][30][31] and the ability of OCP to incorporate carboxylic acid anions into its structure. 14,[32][33][34][35][36][37][38][39][40][41][42][43][44] Carboxylic acid anions locate to the hydrated layer of OCP 14,34,42,44,45 where they bind to the apatitic-like structures either side of the OCP hydrated layers. Nucleation of HAp within an OCP lattice is hypothesized to begin in the apatitic layers of OCP and we reasoned that the presence of citrate and/ or lactate in the OCP hydrated layers would mimic the close presence of those anions around forming apatitic crystals in in vivo bone mineral formation.…”

Section: Resultsmentioning

confidence: 99%

Metabolic acids impact bone mineral maturation

Reid

et al. 2022

Preprint

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Bone mineral has a complex 3D architecture that is essential to its mechanical properties. It is a complex calcium phosphate phase related to hydroxyapatite that also contains significant quantities of cell respiration metabolites, in particular: carbonate, citrate and lactate. An as-yet unanswered question is what, if any, role do these metabolites collectively play in determining the 3D architecture of bone mineral? Here we synthesize apatitic materials by transformation from precursor mineral phases containing citrate, lactate or carbonate so that the synthesis environment mimics the densely-packed ionic environment within which bone mineral forms in vivo, and so that we can understand the mineral factors that may direct bone mineral 3D architecture. We show that incorporating citrate and lactate leads to complex mineral architectures reminiscent of those in bone mineral, including curvature of the mineral crystals. Our results suggest that metabolic acids may assist the moulding of bone mineral to restricted spaces available for mineral in in vivo bone. We find that the incorporation of lactate creates a softer material and inhibits the transformation towards apatitic structures, which may help to explain why foetal bone, necessarily soft, contains considerable quantities of lactate. High levels of plasma citrate have been previously found to correlate with high bone mineral density. Here we find that citrate incorporation leads to mineral crystal curvature modelling that in in vivo bone mineral suggesting its importance in mineral morphology. We conclude that metabolic anions may play an important role in controlling bone mineral physicochemical properties and 3D architecture.

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Octacalcium phosphate: Innovative vehicle for the local biologically active substance delivery in bone regeneration

Cited by 35 publications

References 196 publications

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Calcium Silicate Whiskers‐Enforced Poly(Ether‐Ether‐Ketone) Composites with Improved Mechanical Properties and Biological Activities for Bearing Bone Reconstruction

Metabolic acids impact bone mineral maturation

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