OCT Technique: Past, Present and Future

Kostanyan, Tigran; Cadena, Maria de los Angeles Ramos; Wollstein, Gadi; Schuman, Joel S.

doi:10.1007/978-3-030-26269-3_2

Cited by 2 publications

(3 citation statements)

References 65 publications

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“…Current commercial OCT devices achieve axial resolutions up to 4 μm, and research systems achieve up to 1 μm. The lateral resolution of OCT is determined by the spot size, which is within a range of 15 to 20 μm among different OCT generations (Kostanyan et al 2020). The great penetration depth (1.5 to 2 mm) of OCT allows imaging of the whole oral epithelium and subepithelial microscopic structures (Lee et al 2015).…”

Section: Optical Imaging Techniques In the Diagnosis Of Opmds Maligna...mentioning

confidence: 99%

Optical Imaging in the Diagnosis of OPMDs Malignant Transformation

Deng

Sun

et al. 2022

J Dent Res

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Oral potentially malignant disorders (OPMDs) are a heterogeneous group of oral lesions with a variable risk of malignant transformation to oral squamous cell carcinoma. The current OPMDs malignant transformation screening depends on conventional oral examination (COE) and is confirmed by biopsy and histologic examination. However, early malignant lesions with subtle mucosal changes are easily unnoticed by COE based on visual inspection and palpation. Optical techniques have been used to determine the biological structure, composition, and function of cells and tissues noninvasively by analyzing the changes in their optical properties. The oral epithelium and stroma undergo persistent structural, functional, and biochemical alterations during malignant transformation, leading to variations in optical tissue properties; optical techniques are thus powerful tools for detecting OPMDs malignant transformation. The optical imaging methods already used to detect OPMDs malignant transformation in vivo include autofluorescence imaging, narrowband imaging, confocal reflectance microscopy, and optical coherence tomography. They exhibit advantages over COE in detecting biochemical or morphologic changes at the molecular or cellular level in vivo; however, limitations also exist. This article comprehensively reviews the various real-time in vivo optical imaging methods used in the adjunctive diagnosis of OPMDs malignant transformation. We focus on the principles of these techniques, review their clinical application, and compare and summarize their advantages and disadvantages. Finally, we conclude with a discussion of current challenges and future directions of this field.

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Section: Optical Imaging Techniques In the Diagnosis Of Opmds Maligna...mentioning

confidence: 99%

Optical Imaging in the Diagnosis of OPMDs Malignant Transformation

Deng

Sun

et al. 2022

J Dent Res

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“…En face OCT also known as C-scan OCT is an advanced processing application of OCT images created by participating the information from whole A-scans into a picture of the retinal surface in the desired slab, allows frontal portions of retinal layers to be viewed precisely. The en face images are equal to the depth-resolved retinal fundus images with additional focus on specific sites within the region of interest [9,10].…”

Section: Open Accessmentioning

confidence: 99%

“…OCT angiography (OCTA) has provided better insight into the nature of the retinal vascular pathologies including diabetic retinopathy (DR), central retinal vein occlusion (CRVO), and arterial hypoperfusion [8][9][10][11][12]. OCTA delivers depth-resolved retinal vascular structure images, making it possible to differentiate capillary plexuses at superficial and deep layers of the retina; a phenomenon in which fluorescein angiography (FA) as the conventional…”

Section: Introductionmentioning

confidence: 99%

Multimodal imaging for paracentral acute maculopathy; the diagnostic role of en face OCT

et al. 2021

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Background To describe the features of multimodal imaging and the diagnostic role of en face OCT in the paracentral acute middle maculopathy (PAMM) spectrum. Methods In this observational case series, 5 eyes of 5 patients with acute PAMM were identified. Demographic characteristics as well as data regarding the underlying disease, presenting visual acuity (VA) and ophthalmic examination results were recorded. All patients underwent multimodal imaging within 3 days after symptom onset. Results The mean age of patients was 52.2 (range, 33–67) years. Systemic comorbidities including diabetes mellitus and hypertension were identified in two patients. Except for one patient diagnosed with isolated PAMM, other patients had signs of retinal vascular disease such as a cilioretinal artery or branch retinal artery obstruction, non-ischemic central retinal vein occlusion, or a combination of these vascular disorders. The central vision was preserved in two cases; however, the remaining cases presented with profound VA reduction. Different patterns of PAMM including arterial, globular, and fern-like were observed in en face OCT at deep capillary plexus (DCP) level. En face OCT images could precisely delineate the margin of the PAMM area. Optical coherence tomography angiography (OCTA) showed decreased vascular density in DCP. Unresolved projection artifact by conventional OCTA software was observed in DCP and choriocapillaris slabs in all cases. Conclusion En face structural OCT in PAMM can delineate the area of ischemia and the degree of foveal involvement. Unresolved projection artifact by conventional OCTA software in the PAMM area can be seen in DCP and choriocapillaris layers.

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OCT Technique: Past, Present and Future

Cited by 2 publications

References 65 publications

Optical Imaging in the Diagnosis of OPMDs Malignant Transformation

Optical Imaging in the Diagnosis of OPMDs Malignant Transformation

Multimodal imaging for paracentral acute maculopathy; the diagnostic role of en face OCT

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